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FLASH GENE
Symbol HLA-DMA contributors: npt/ - updated : 23-04-2005
HGNC name major histocompatibility complex, class II, DM alpha
HGNC id 4934
Location 6p21.3      Physical location : 4.148.516 - 32.920.899
Synonym name
  • HLA-DM,alpha chain,same as RING6
  • MHC class II antigen DMA
  • class II histocompatibility antigen, M alpha chain
  • Synonym symbol(s) D6S222E, RING6, DMA, HLADM
    DNA
    TYPE functioning gene
    STRUCTURE 4.46 kb     5 Exon(s)
    MAPPING cloned Y linked N status confirmed
    Physical map
    HLA-DRB2 6p21.3 major histocompatibility complex, class II, DR beta 2 HLA-DRB1 6p21.3 major histocompatibility complex, class II, DR beta 1 HLA-DQA1 6p21.3 major histocompatibility complex, class II, DQ alpha 1 HLA-DQB1 6p21.3 major histocompatibility complex, class II, DQ beta 1 HLA-DQA2 6p21.3 major histocompatibility complex, class II, DQ alpha 2 HLA-DQB2 6p21.3 major histocompatibility complex, class II, DQ beta 2 HLA-DOB 6p21.3 major histocompatibility complex, class II, DO beta TAP2 6p21.3 transporter 2, ATP-binding cassette, sub-family B (MDR/TAP) PSMB8 6p21.3 proteasome (prosome, macropain) subunit, beta type, 8 (large multifunctional protease 7) TAP1 6p21.3 transporter 1, ATP-binding cassette, sub-family B (MDR/TAP) PSMB9 6p21.3 proteasome (prosome, macropain) subunit, beta type, 9 (large multifunctional protease 2) PPP1R2P1 6p21.31 protein phosphatase 1, regulatory (inhibitor) subunit 2 pseudogene 1 LOC389380 6 LOC389380 HLA-DMB 6p21.3 major histocompatibility complex, class II, DM beta HLA-DMA 6p21.3 major histocompatibility complex, class II, DM alpha BRD2 6p21.3 bromodomain containing 2 HLA-DOA 6p21.3 major histocompatibility complex, class II, DO alpha HLA-DPA1 6p21.3 major histocompatibility complex, class II, DP alpha 1 HLA-DPB1 6p21.3 major histocompatibility complex, class II, DP beta 1 RPL32P1 6p21.3 ribosomal protein L32 pseudogene 1 LOC391913 6 similar to MHC HLA-SX-alpha HLA-DPB2 6p21.3 major histocompatibility complex, class II, DP beta 2 (pseudogene) COL11A2 6p21.3 collagen, type XI, alpha 2 RXRB 6p21.3 retinoid X receptor, beta SLC39A7 6p21.3 solute carrier family 39 (zinc transporter), member 7 HSD17B8 6p21.3 hydroxysteroid (17-beta) dehydrogenase 8 RING1 6p21.3 ring finger protein 1
    RNA
    TRANSCRIPTS type messenger
    identificationnb exonstypebpproduct
    ProteinkDaAAspecific expressionYearPubmed
    5 - 1122 29 261 - -
    EXPRESSION
    Type restricted
       expressed in (based on citations)
    organ(s)
    tissue
    SystemTissueTissue level 1Tissue level 2LevelPubmedSpeciesStageRna symbol
    Blood / Hematopoietic    
    Lymphoid    
    cells
    SystemCellPubmedSpeciesStageRna symbol
    Lymphoid/ImmuneB cell
    Lymphoid/Immunemacrophage
    cell lineage
    cell lines
    fluid/secretion
    at STAGE
    PROTEIN
    PHYSICAL PROPERTIES
    STRUCTURE
    motifs/domains
  • two extracellular globular domains, alpha 1, alpha 2
  • a transmembrane segment
  • a cytoplasmic tail
  • conjugated GlycoP
    mono polymer heteromer , dimer
    isoforms Precursor
    HOMOLOGY
    Homologene
    FAMILY
  • HLA-class II family
  • CATEGORY antigen
    SUBCELLULAR LOCALIZATION     plasma membrane
        intracellular
    intracellular,cytoplasm,organelle,membrane
    intracellular,cytoplasm,organelle,endoplasmic reticulum
    intracellular,cytoplasm,organelle,lysosome
    intracellular,cytoplasm,cytosolic,vesicle
    basic FUNCTION
  • chaperone for MHC class II compartment (molecules in endosomal and lysosomal loading compartments)
  • affecting the peptide repertoire presented on the cell surface of antigen presenting cells
  • CELLULAR PROCESS
    PHYSIOLOGICAL PROCESS immunity/defense
    PATHWAY
    metabolism
    signaling
    a component
  • heterodimer of alpha and beta-chain, the alpha 1 domain forming the peptide groove with the beta 1 domain of HLA-DMB
  • INTERACTION
    DNA
    RNA
    small molecule
    protein
  • releasing the CLIP molecule from the peptide binding site
  • cell & other
    REGULATION
    ASSOCIATED DISORDERS
    corresponding disease(s)
    Susceptibility to systemic lupus erythematosus
    Variant & Polymorphism 0104 allele associated with systemic lupus erythematosus
    Candidate gene
    Marker
    Therapy target
    ANIMAL & CELL MODELS