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FLASH GENE
Symbol HLA-DMA contributors: npt/ - updated : 23-04-2005
HGNC name major histocompatibility complex, class II, DM alpha
HGNC id 4934
Location 6p21.3      Physical location : 4.148.516 - 32.920.899
Synonym name
  • HLA-DM,alpha chain,same as RING6
  • MHC class II antigen DMA
  • class II histocompatibility antigen, M alpha chain
  • Synonym symbol(s) D6S222E, RING6, DMA, HLADM
    DNA
    TYPE functioning gene
    STRUCTURE 4.46 kb     5 Exon(s)
    MAPPING cloned Y linked N status confirmed
    RNA
    TRANSCRIPTS type messenger
    identificationnb exonstypebpproduct
    ProteinkDaAAspecific expressionYearPubmed
    5 - 1122 29 261 - -
    EXPRESSION
    Type restricted
       expressed in (based on citations)
    organ(s)
    tissue
    SystemTissueTissue level 1Tissue level 2LevelPubmedSpeciesStageRna symbol
    Blood / Hematopoietic    
    Lymphoid    
    cells
    SystemCellPubmedSpeciesStageRna symbol
    Lymphoid/ImmuneB cell
    Lymphoid/Immunemacrophage
    cell lineage
    cell lines
    fluid/secretion
    at STAGE
    PROTEIN
    PHYSICAL PROPERTIES
    STRUCTURE
    motifs/domains
  • two extracellular globular domains, alpha 1, alpha 2
  • a transmembrane segment
  • a cytoplasmic tail
  • conjugated GlycoP
    mono polymer heteromer , dimer
    isoforms Precursor
    HOMOLOGY
    Homologene
    FAMILY
  • HLA-class II family
  • CATEGORY antigen
    SUBCELLULAR LOCALIZATION     plasma membrane
        intracellular
    intracellular,cytoplasm,organelle,membrane
    intracellular,cytoplasm,organelle,endoplasmic reticulum
    intracellular,cytoplasm,organelle,lysosome
    intracellular,cytoplasm,cytosolic,vesicle
    basic FUNCTION
  • chaperone for MHC class II compartment (molecules in endosomal and lysosomal loading compartments)
  • affecting the peptide repertoire presented on the cell surface of antigen presenting cells
  • CELLULAR PROCESS
    PHYSIOLOGICAL PROCESS immunity/defense
    PATHWAY
    metabolism
    signaling
    a component
  • heterodimer of alpha and beta-chain, the alpha 1 domain forming the peptide groove with the beta 1 domain of HLA-DMB
  • INTERACTION
    DNA
    RNA
    small molecule
    protein
  • releasing the CLIP molecule from the peptide binding site
  • cell & other
    REGULATION
    ASSOCIATED DISORDERS
    corresponding disease(s)
    Susceptibility to systemic lupus erythematosus
    Variant & Polymorphism 0104 allele associated with systemic lupus erythematosus
    Candidate gene
    Marker
    Therapy target
    ANIMAL & CELL MODELS