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FLASH GENE
Symbol HIVEP3 contributors: mct/npt - updated : 11/09/2009
HGNC name human immunodeficiency virus type I enhancer binding protein 3
HGNC id 13561
Location 1p34.2      Physical location : 41.975.684 - 42.384.496
Synonym name
  • zinc finger transcription factor kappa recognition component
  • kappa binding protein-1
  • kappa-B and V(D)J recombination signal sequences-binding
  • protein
  • Schnnuri3
  • Synonym symbol(s) KRC, KBP1, KIAA1555, ZAS1, ZAS3, FLJ16752, KBP-1, SHN3, FLJ16752, , Schnurri-3, ZNF40C
    DNA
    TYPE functioning gene
    STRUCTURE 408.81 kb     9 Exon(s)
    Genomic sequence alignment details
    10 Kb 5' upstream gene genomic sequence study
    text structure
  • harbors two promoters that are 80 kb apart
  • expression controlled by a combination of differential promoter usage, alternative splicing, and possible intergenic splicing
  • MAPPING cloned Y linked Y status provisional
    Physical map
    CAP1 1p34.2 CAP, adenylate cyclase-associated protein 1 (yeast) PPT1 1p32 palmitoyl-protein thioesterase 1 (ceroid-lipofuscinosis, neuronal 1, infantile) RLF 1p32 rearranged L-myc fusion sequence LOC127391 1p34.2 similar to dJ39G22.2 (novel protein) ZMPSTE24 1p34.1-p33 zinc metalloproteinase (STE24 homolog, yeast) COL9A2 1p33-p32.3 collagen, type IX, alpha 2 LOC388621 1 similar to 60S ribosomal protein L21 LOC391028 1 similar to Csa-19 LOC64744 1p35.3-p34.1 hypothetical protein AL133206 LOC65243 1p34.2 hypothetical protein LOC65243 FLJ16030 1p34.2 FLJ16030 protein FLJ21144 1p34.2 hypothetical protein FLJ21144 MGC27466 1p34.2 hypothetical protein MGC27466 LOC391029 1 similar to General transcription factor IIF, polypeptide 2 RIMS3 1pter-p22.2 regulating synaptic membrane exocytosis 3 NFYC 1p32 nuclear transcription factor Y, gamma KCNQ4 1p34 potassium voltage-gated channel, KQT-like subfamily, member 4 CITED4 1p34.1 Cbp/p300-interacting transactivator, with Glu/Asp-rich carboxy-terminal domain, 4 LOC388622 1 LOC388622 CTPS 1p34.1 CTP synthase FLJ23878 1p34.1 hypothetical protein FLJ23878 SCMH1 1p34 sex comb on midleg homolog 1 (Drosophila) LOC388623 1 LOC388623 LOC391030 1 similar to forkhead box protein O6 EDN2 1p34.1 endothelin 2 HIVEP3 1p34 human immunodeficiency virus type I enhancer binding protein 3 LOC391031 1 similar to Heterogeneous nuclear ribonucleoprotein F (hnRNP F) GUCA2B 1p35-p34 guanylate cyclase activator 2B (uroguanylin) GUCA2A 1p35-p34 guanylate cyclase activator 2A (guanylin) KIAA1041 1p35-p32 guanylate cyclase activator 2A (guanylin) MGC47816 1p34.1 hypothetical protein MGC47816 ZMYND12 1p34.1 zinc finger, MYND domain containing 12 FLJ11838 1p34.1 hypothetical protein FLJ11838 FLJ20972 1p34.1 hypothetical protein FLJ20972 TMSL1 1 thymosin-like 1 PPIH 1p34.1 peptidyl prolyl isomerase H (cyclophilin H) NSEP1 1p34 nuclease sensitive element binding protein 1 CLDN19 1p33-34.2 claudin 19 LEPRE1 1p34.1 leucine proline-enriched proteoglycan (leprecan) 1 MGC955 1p34.1 hypothetical protein MGC955 LOC388624 1 LOC388624
    RNA
    TRANSCRIPTS type messenger
    identificationnb exonstypebpproduct
    ProteinkDaAAspecific expressionYearPubmed
    8 - 8792 - 2405 - Hicar, Li (2007)
    also called HIVEP3-S
    9 - 8875 259.3 2406 - Hicar, Li (2007)
    also called HIVEP3-L
    EXPRESSION
    Type widely
       expressed in (based on citations)
    organ(s)
    SystemOrgan level 1Organ level 2Organ level 3Organ level 4LevelPubmedSpeciesStageRna symbol
    Digestivepharynx   moderately
    Endocrinethyroid   highly
    Lymphoid/Immunelymph node   moderately
    Nervousbrain    
    Reproductivefemale systembreastmammary gland highly
    Respiratorylung    
     respiratory tractlarynx  moderately
    Urinarykidney    
    cell lineage
    cell lines
    fluid/secretion lymph
    at STAGE
    PROTEIN
    PHYSICAL PROPERTIES acid
    STRUCTURE
    motifs/domains
  • two C2H2 zinc finger binding domains
  • a C-terminal DNA-binding domain
  • a leucine zipper
  • ZAS1 and ZAS2 domains
  • GTPase motifs
  • HOMOLOGY
    interspecies ortholog to rattus Hivep3 (82.7pc)
    ortholog to murine Hivep3 (81pc)
    intraspecies paralog to HIVEP1
    paralog to HIVEP2
    Homologene
    FAMILY
  • Schnurri protein family
  • CATEGORY DNA associated , transcription factor
    SUBCELLULAR LOCALIZATION     intracellular
    intracellular,cytoplasm
    intracellular,nucleus
    basic FUNCTION
  • regulating transcription via the kappa-B enhancer motif
  • being a participant in the signal transduction pathway leading from the TNF receptor to gene activation
  • playing a critical role in inflammatory and apoptotic responses
  • negatively regulating COL2A1
  • unique and redundant functions reside in the Schnurri protein family that are required for proper skeletal patterning and remodeling
  • CELLULAR PROCESS nucleotide, transcription, regulation
    PHYSIOLOGICAL PROCESS
    text transcriptional activator
    PATHWAY
    metabolism
    signaling signal transduction
    a component
    INTERACTION
    DNA binding
    RNA
    small molecule metal binding,
  • Zn2+
  • protein
  • TRAF2
  • cell & other
    REGULATION
    ASSOCIATED DISORDERS
    corresponding disease(s)
    Susceptibility to Parkinson disease (PARK10)
    Variant & Polymorphism
    Candidate gene
    Marker
    Therapy target
    ANIMAL & CELL MODELS
    deletion of Shn2 and Shn3 in mice impairs growth plate maturation during endochondral ossification but simultaneously results in massively elevated trabecular bone formation