Selected-GenAtlas references SOURCE GeneCards NCBI Gene Swiss-Prot Ensembl
HGNC UniGene Nucleotide OMIM UCSC
Home Page
FLASH GENE
Symbol HIVEP2 contributors: mct - updated : 18-09-2017
HGNC name human immunodeficiency virus type I enhancer binding protein 2
HGNC id 4921
Corresponding disease
MRD43 mental retardation, autosomal dominant 43
Location 6q24.2      Physical location : 143.072.604 - 143.266.338
Synonym name
  • C-Myc intron binding protein
  • MHC-binding protein 2
  • Schnurri-2
  • Synonym symbol(s) MBP-2, HIV-EP2, MIBP1, ZAS2, Schnurri-2, ZNF40B, SHn-2, HIV-EP2, MBP-2, MIBP1, MRD43, SHN2
    DNA
    TYPE functioning gene
    STRUCTURE 193.74 kb     10 Exon(s)
    10 Kb 5' upstream gene genomic sequence study
    MAPPING cloned Y linked N status provisional
    Physical map
    LOC391975 6 similar to ATP synthase B chain, mitochondrial precursor LOC340149 6q24.1 hypothetical LOC340149 LOC391976 6 similar to SUMO-1 activating enzyme subunit 2 NMBR 6q23 neuromedin B receptor C6orf55 6q24.1 chromosome 6 open reading frame 55 GPR126 6q23.1-q24.3 G protein-coupled receptor 126 HIVEP2 6q23-q24 human immunodeficiency virus type I enhancer binding protein 2 AIG1 6q24.1 androgen-induced 1 DEADC1 6q24.1 deaminase domain containing 1 LOC391977 6 similar to dJ20N2.2 (novel protein similar to tubulin, beta polypeptide 4, member Q (TUBB4Q)) PEX3 6q23-q24 peroxisomal biogenesis factor 3 FUCA2 6q25-qter fucosidase, alpha-L- 2, plasma C6orf56 6q24.1 chromosome 6 open reading frame 56 C6orf93 6q24.1 chromosome 6 open reading frame 93 LOC153918 6q24.1 similar to CGI-62 protein PLAGL1 6q25 pleiomorphic adenoma gene-like 1 SF3B5 6q24.1 splicing factor 3b, subunit 5, 10kDa MRPL42P3 6q24.2 splicing factor 3b, subunit 5, 10kDa STX11 6q23.1-q25.3 syntaxin 11 LOC285741 6q24.1 similar to Translationally controlled tumor protein (TCTP) (p23) (Histamine-releasing factor) (HRF) UTRN 6q24 utrophin (homologous to dystrophin) LOC391978 6 similar to ZNF131 protein EPM2A 6q24.3 epilepsy, progressive myoclonus type 2A, Lafora disease (laforin) FBXO30 6q24 F-box protein 30 SHPRH 6q24.2 SNF2 histone linker PHD RING helicase
    RNA
    TRANSCRIPTS type messenger
    identificationnb exonstypebpproduct
    ProteinkDaAAspecific expressionYearPubmed
    10 - 9732 - 2446 - 2004 15009192
    EXPRESSION
    Type widely
    constitutive of
       expressed in (based on citations)
    organ(s)
    SystemOrgan level 1Organ level 2Organ level 3Organ level 4LevelPubmedSpeciesStageRna symbol
    Cardiovascularheart    
    Digestivemouthtongue  highly
    Lymphoid/Immunelymph node   highly
    Nervousbrain    
    Respiratoryrespiratory tractlarynx  highly
    Urinarykidney    
    tissue
    SystemTissueTissue level 1Tissue level 2LevelPubmedSpeciesStageRna symbol
    Blood / Hematopoieticbone marrow   
    Muscularstriatumskeletal  
    cells
    SystemCellPubmedSpeciesStageRna symbol
    Nervousneuron
    cell lineage
    cell lines
    fluid/secretion
    at STAGE
    PROTEIN
    PHYSICAL PROPERTIES
    STRUCTURE
    motifs/domains
  • ZAS1 and ZAS2 domain
  • 12 T/SPXR/K motifs
  • four C2H2-type zinc fingers
  • HOMOLOGY
    interspecies ortholog to murine Hivep2
    homolog to Drosophila shn
    homolog to C.elegans C46C2.1
    intraspecies paralog to HIVEP1,HIVEP3
    Homologene
    FAMILY
  • Schnurri protein family
  • CATEGORY immunity/defense
    SUBCELLULAR LOCALIZATION     intracellular
    intracellular,nucleus
    basic FUNCTION
  • may be functioning as a transcriptional repressor
  • playing a crucial role in maintaining cellular homeostasis at least in part by inhibiting NFKB
  • plays a critical role in cell growth, signal transduction and lymphocyte development
  • regulates Th2-dependent airway inflammation and airway hyperresponsiveness
  • unique and redundant functions reside in the Schnurri protein family that are required for proper skeletal patterning and remodeling
  • large zinc-finger containing protein, which plays a critical role in cell growth, signal transduction and lymphocyte development
  • HIVEP2-mediated repression of NF-kappaB is required for cell survival and the successful generation of memory Th1/Th2 cells
  • transcriptional modulator of bone formation and bone resorption
  • acts to dampen death induced by TCR signalling, thereby allowing positive selection to proceed in response to signals of intermediate strength
  • critical regulator of T-cell development that controls the balance between death and differentiation
  • is considered to play an important role in the activation and function of NK cells and the development of T cell lymphoma
  • nuclear factor-kappaB site-binding protein, tightly binds to the enhancers of major histocompatibility complex class I genes and inflammatory cytokines
  • CELLULAR PROCESS cell life
    PHYSIOLOGICAL PROCESS
    PATHWAY
    metabolism
    signaling
    a component
    INTERACTION
    DNA binding to 5'-GGGACTTTCC-3' sequence which is found in the enhancer elements of numerous viral promoters such as those of SV40,CMV or HIV1
    RNA
    small molecule
    protein
  • with TRAF2 to repress TNF/NFKB signal pathway
  • interacts with TCF4
  • CLIC4, a multifunctional protein that traffics between the cytoplasm and nucleus, interacts with HIVEP2 (HIVEP2 and CLIC4 are modifiers of TGF-beta signalling through their stabilization of p-Smad2 and 3 in the nucleus)
  • cell & other
    REGULATION
    induced by mitogen and phorbol ester
    ASSOCIATED DISORDERS
    corresponding disease(s) MRD43
    Other morbid association(s)
    TypeGene ModificationChromosome rearrangementProtein expressionProtein Function
    tumoral     --low  
    significantly depressed in the high malignancy gliomas group (WHO grade IV)
    Susceptibility
    Variant & Polymorphism
    Candidate gene
    Marker
    Therapy target
    ANIMAL & CELL MODELS
  • Shn2-deficient mice maintain bone mass at the levels comparable to wild-type sham mice even after ovariectomy-induced bone loss and this correlates with the high levels of mineralization activity in bone marrow cells after ovariectomy
  • deletion of Shn2 and Shn3 in mice impairs growth plate maturation during endochondral ossification but simultaneously results in massively elevated trabecular bone formation
  • Hivep2-knockout mice exhibit several working memory deficits, increased anxiety, and hyperactivity