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FLASH GENE
Symbol HIST4H4 contributors: mct/npt - updated : 07-04-2009
HGNC name histone 4, H4
HGNC id 20510
Location 12p12.3      Physical location : 14.923.654 - 14.924.065
Synonym name
  • histone H4
  • histone cluster 4, H4
    • Synonym symbol(s) HIST2H4, MGC24116, A2VCL0, H4/A, H4/B, H4/C, H4/D, H4/E, H4/G, H4/H, H4/I, H4/J, H4/K, H4/M, H4/N, H4/O, H4F2, H4FA, H4FB, H4FC, H4FD, H4FE, H4FG, H4FH, H4FI, H4FJ, H4FK, H4FM, H4FN, H4FO, HIST1H4A, HIST1H4B, HIST1H4C, HIST1H4D, HIST1H4E, HIST1H4F, HIST1H
    DNA
    TYPE functioning gene
    STRUCTURE 0.41 kb     1 Exon(s)
    10 Kb 5' upstream gene genomic sequence study
    MAPPING cloned Y linked N status provisional
    RNA
    TRANSCRIPTS type messenger
    identificationnb exonstypebpproduct
    ProteinkDaAAspecific expressionYearPubmed
    1 - 412 11.24 103 - Kalakonda (2008)
    EXPRESSION
    Type restricted
       expressed in (based on citations)
    organ(s)
    SystemOrgan level 1Organ level 2Organ level 3Organ level 4LevelPubmedSpeciesStageRna symbol
    Digestivemouth    
    Lymphoid/Immunespleen    
    cell lineage
    cell lines
    fluid/secretion
    at STAGE
    PROTEIN
    PHYSICAL PROPERTIES
    STRUCTURE
    motifs/domains
  • N-terminal tail may play a major regulator in chromatin structure and function
    • HOMOLOGY
    Homologene
    FAMILY
  • histone H4 family
    • CATEGORY DNA associated
    SUBCELLULAR LOCALIZATION     intracellular
    intracellular,nucleus,chromatin/chromosome
    basic FUNCTION
  • playing a role in mediating recruitment of multiple regulatory factors that can change chromatin states for transcription regulation (Choi 2007)
    • CELLULAR PROCESS
    PHYSIOLOGICAL PROCESS
    PATHWAY
    metabolism
    signaling
    a component
    INTERACTION
    DNA
    RNA
    small molecule
    protein
  • interacting with SETD8 and L3MBTL (importance of HIST4H4 monomethylation and of SETD8 for L3MBTL function) (Kalakonda 2008)
    • cell & other
    REGULATION
    ASSOCIATED DISORDERS
    ANIMAL & CELL MODELS