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FLASH GENE
Symbol HIST3H3 contributors: mct - updated : 08-09-2010
HGNC name histone cluster 3, H3
HGNC id 4778
Location 1q42.13      Physical location : 228.612.545 - 228.613.026
Synonym name
  • histone 3, H3
  • H3 histone family, member T
  • Synonym symbol(s) H3T, H3/G, H3.4, H3FT, MGC126886, MGC126888
    DNA
    TYPE functioning gene
    SPECIAL FEATURE component of a cluster
    STRUCTURE 0.48 kb     1 Exon(s)
    Genomic sequence alignment details
    10 Kb 5' upstream gene genomic sequence study
    regulatory sequence Promoter
    text structure consensus promter and 3prime flanking portions typical or replication dependent histones
    MAPPING cloned Y linked N status confirmed
    Physical map
    MGC15634 1q42.13 hypothetical protein MGC15634 FLJ12517 1q42.13 hypothetical protein FLJ12517 IMAGE3451454 1q42.13 SVAP1 protein MPN2 1q42.13 marapsin 2 WNT9A 1q42 wingless-type MMTV integration site family, member 9A LOC340346 1q42.13 hypothetical gene supported by AK093729; AK096776; AL117642 LOC391173 1 similar to capicua homolog WNT3A 1q42 wingless-type MMTV integration site family, member 3A DKFZp434C0923 1q42.13 hypothetical protein DKFZp434C0923 ARF1 1q42 ADP-ribosylation factor 1 C1orf35 1q42.13 chromosome 1 open reading frame 35 MRPL55 1p36.3 mitochondrial ribosomal protein L55 LOC391174 1 similar to hypothetical protein FLJ22875 GUK1 1q32-q41 guanylate kinase 1 GJA12 1q41-q42 gap junction protein, alpha 12, 47kDa LOC200205 1q42.13 hypothetical protein LOC200205 FLJ14124 1q42.13 hypothetical protein FLJ14124 KIAA1639 1q42.13 KIAA1639 protein TRIM11 1q42.13 tripartite motif-containing 11 TRIM17 1q42 tripartite motif-containing 17 HIST3H3 1q42 histone 3, H3 LOC391175 1 similar to 60S ribosomal protein L23a HIST3H2A 1q42.13 histone 3, H2a HIST3H2BB 1q42.13 histone 3, H2bb HIST3H2BA 1 histone 3, H2ba LOC149603 1q42.13 hypothetical protein LOC149603 FLJ31401 1q42.13 hypothetical protein FLJ31401 LOC388750 1 similar to Ferritin heavy chain (Ferritin H subunit) ARHU 1q42.11-q42.3 ras homolog gene family, member U LOC388751 1 LOC388751
    RNA
    TRANSCRIPTS type messenger
    identificationnb exonstypebpproduct
    ProteinkDaAAspecific expressionYearPubmed
    1 - 481 15.4 136 - Ishimi (1996)
    EXPRESSION
    Type
       expressed in (based on citations)
    organ(s)
    SystemOrgan level 1Organ level 2Organ level 3Organ level 4LevelPubmedSpeciesStageRna symbol
    Reproductivemale systemtestis  highly
    cell lineage
    cell lines
    fluid/secretion
    at STAGE
    PROTEIN
    PHYSICAL PROPERTIES
    STRUCTURE
    motifs/domains
    conjugated Other
    mono polymer octamer
    HOMOLOGY
    Homologene
    FAMILY
  • histone H3 family
  • CATEGORY DNA associated , transcription factor
    SUBCELLULAR LOCALIZATION     intracellular
    intracellular,nucleus,nucleoplasm
    intracellular,nucleus,chromatin/chromosome,nucleosome
    text incorporated into the chromatin in the early stage of spermatogenesis (Tachiwana 2010)
    basic FUNCTION
  • dynamic changes in chromatin structure through post-translational modifications of HIST3H3 during replication origin activation (Rampakakis 2009)
  • playing a role in the compaction of DNA into nucleosomes
  • may be assembled into the chromatin by a specific chaperone-mediated pathway in the testis (Tachiwana 2010)
  • prominent property of the H3T nucleosome is its instability (Tachiwana 2010)
  • may have a specific function in chromatin reorganization during meiosis and/or the postmeiotic maturation of male germ cells (Tachiwana 2010)
  • specific biochemical and structural properties of the H3T nucleosome, like those containing the H2B variants, could also play an important epigenetic role in the regulation of genes containing nucleosomes in the sperm (Tachiwana 2010)
  • CELLULAR PROCESS nucleotide, chromatin organization, remodeling
    nucleotide, transcription, regulation
    PHYSIOLOGICAL PROCESS
    PATHWAY
    metabolism
    signaling
    a component
  • core histone H2A/H2B/H3/H4
  • INTERACTION
    DNA binding approximatively 0.146 kb
    RNA
    small molecule
    protein
  • H2A, H2B, H3, H4
  • H3K4me3, through interactions with TAF3, directs global TBP recruitment
  • cell & other
    REGULATION
    ASSOCIATED DISORDERS
    ANIMAL & CELL MODELS