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FLASH GENE

Symbol

HIST1H1T

contributors: shn/npt - updated : 09-06-2009

HGNC name	histone cluster 1, H1t
HGNC id	4720

FLASH GENE DNA RNA EXPRESSION PROTEIN DISORDER ANIMAL & CELL MODELS

Location	6p22.2      Physical location : 26.107.640 - 26.108.364
Synonym name	histone 1, H1t
	histone cluster 1, H1t
	linker histone 1 subtype T
	H1 histone family, member T (testis-specific)
Synonym symbol(s)	H1t, H1FT, dJ221C16.2, MGC163222, dJ221C16.2

DNA

TYPE	functioning gene
SPECIAL FEATURE	component of a cluster
STRUCTURE	0.73 kb     1 Exon(s)    1 Copie(s)

10 Kb 5' upstream gene genomic sequence study

regulatory sequence	Promoter (CAAT box)
text structure	H1t/CCTAGG sequence element between the H1/GC box and H1/CCAAT box

MAPPING

cloned

Y

linked

status

provisional

Map	pter - D6S1545 - D6S1621 - HIST1H1T - D6S394 - D6S1016 - cen

RNA

TRANSCRIPTS	type	messenger

text	Transcripts from this gene lack polyA tails but instead contain a palindromic termination element

identification nb exons type bp product Protein kDa AA specific expression Year Pubmed variant 1 1 - 725 isoform 1 21.9 207 expressed exclusively in spermatocytes Cavalcanti (2009)

EXPRESSION

Type	restricted

expressed in	(based on citations)
organ(s)	System Organ level 1 Organ level 2 Organ level 3 Organ level 4 Level Pubmed Species Stage Rna symbol Reproductive male system testis     specific

cells

System Cell Pubmed Species Stage Rna symbol Reproductive spermatocyte

cell lineage	germinal cells: pachytene spermatocytes
cell lines
fluid/secretion

at STAGE

life cycle

PROTEIN

PHYSICAL PROPERTIES		basic
STRUCTURE

motifs/domains	central, globular DNA-binding domain
	a N terminal lysine-rich region
	a C terminal region with oligopeptide repeats enriched in serine, proline lysine
	a CDK consensus motif

conjugated

RiboP

HOMOLOGY

interspecies	homolog to C.elegans f22f1.1
	ortholog to Hist1h1t, Mus musculus
	ortholog to Hist1h1t, Rattus norvegicus

Homologene

FAMILY

histone H1 family

CATEGORY

DNA associated , transcription factor

SUBCELLULAR LOCALIZATION	intracellular
	intracellular,nucleus,chromatin/chromosome

basic FUNCTION

essential for the condensation of nucleosome chains into higher order structures

CELLULAR PROCESS	cell cycle,division,meiosis
	nucleotide, chromatin organization, remodeling
	nucleotide, transcription, regulation

PHYSIOLOGICAL PROCESS

PATHWAY

metabolism

signaling

a component

INTERACTION

DNA

RNA

small molecule

protein

cell & other

REGULATION

ASSOCIATED DISORDERS

corresponding disease(s)

Susceptibility

Variant & Polymorphism

Candidate gene

Marker

Therapy target

ANIMAL & CELL MODELS

mice lacking histone H1t are fertile and show normal spermatogenesis