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FLASH GENE
Symbol HIST1H1T contributors: shn/npt - updated : 09-06-2009
HGNC name histone cluster 1, H1t
HGNC id 4720
Location 6p22.2      Physical location : 26.107.640 - 26.108.364
Synonym name
  • histone 1, H1t
  • histone cluster 1, H1t
  • linker histone 1 subtype T
  • H1 histone family, member T (testis-specific)
  • Synonym symbol(s) H1t, H1FT, dJ221C16.2, MGC163222, dJ221C16.2
    DNA
    TYPE functioning gene
    SPECIAL FEATURE component of a cluster
    STRUCTURE 0.73 kb     1 Exon(s)    1 Copie(s)
    10 Kb 5' upstream gene genomic sequence study
    regulatory sequence Promoter (CAAT box)
    text structure H1t/CCTAGG sequence element between the H1/GC box and H1/CCAAT box
    MAPPING cloned Y linked   status provisional
    Map pter - D6S1545 - D6S1621 - HIST1H1T - D6S394 - D6S1016 - cen
    Physical map
    HIST1H1PS2 6p21.3 histone 1, H1, pseudogene 2 HIST1H1A 6p22-p21 histone 1, H1a HIST1H3A 6p21.3 histone 1, H3a HIST1H4A 6p21.3 histone 1, H4a HIST1H4B 6p21.3 histone 1, H4b HIST1H3B 6p21.3 histone 1, H3b HIST1H2AB 6p21.3 histone 1, H2ab HIST1H2BB 6p21.3 histone 1, H2bb HIST1H2APS5 6p21.3 histone 1, H2a, pseudogene 5 HIST1H3C 6p21.3 histone 1, H3c HIST1H1C 6p21.3 histone 1, H1c HFE 6p21.3 hemochromatosis HIST1H4C 6p21.3 histone 1, H4c HIST1H1T 6p21.3 histone 1, H1t HIST1H2BC 6p21.3 histone 1, H2bc HIST1H2AC 6p21.3 histone 1, H2ac HIST1H1E 6p21.3 histone 1, H1e HIST1H2BD 6p21.3 histone 1, H2bd HIST1H2BE 6p21.3 histone 1, H2be HIST1H4D 6p21.3 histone 1, H4d
    RNA
    TRANSCRIPTS type messenger
    text Transcripts from this gene lack polyA tails but instead contain a palindromic termination element
    identificationnb exonstypebpproduct
    ProteinkDaAAspecific expressionYearPubmed
    1 - 725 21.9 207 expressed exclusively in spermatocytes Cavalcanti (2009)
    EXPRESSION
    Type restricted
       expressed in (based on citations)
    organ(s)
    SystemOrgan level 1Organ level 2Organ level 3Organ level 4LevelPubmedSpeciesStageRna symbol
    Reproductivemale systemtestis  specific
    cells
    SystemCellPubmedSpeciesStageRna symbol
    Reproductivespermatocyte
    cell lineage germinal cells: pachytene spermatocytes
    cell lines
    fluid/secretion
    at STAGE
    life cycle
    PROTEIN
    PHYSICAL PROPERTIES basic
    STRUCTURE
    motifs/domains
  • central, globular DNA-binding domain
  • a N terminal lysine-rich region
  • a C terminal region with oligopeptide repeats enriched in serine, proline lysine
  • a CDK consensus motif
  • conjugated RiboP
    HOMOLOGY
    interspecies homolog to C.elegans f22f1.1
    ortholog to Hist1h1t, Mus musculus
    ortholog to Hist1h1t, Rattus norvegicus
    Homologene
    FAMILY
  • histone H1 family
  • CATEGORY DNA associated , transcription factor
    SUBCELLULAR LOCALIZATION     intracellular
    intracellular,nucleus,chromatin/chromosome
    basic FUNCTION
  • essential for the condensation of nucleosome chains into higher order structures
  • CELLULAR PROCESS cell cycle,division,meiosis
    nucleotide, chromatin organization, remodeling
    nucleotide, transcription, regulation
    PHYSIOLOGICAL PROCESS
    PATHWAY
    metabolism
    signaling
    a component
    INTERACTION
    DNA
    RNA
    small molecule
    protein
    cell & other
    REGULATION
    ASSOCIATED DISORDERS
    corresponding disease(s)
    Susceptibility
    Variant & Polymorphism
    Candidate gene
    Marker
    Therapy target
    ANIMAL & CELL MODELS
  • mice lacking histone H1t are fertile and show normal spermatogenesis