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FLASH GENE
Symbol HIST1H1E contributors: mct - updated : 06-06-2017
HGNC name histone cluster 1, H1e
HGNC id 4718
Corresponding disease
OGID1 overgrowth and intellectual disability 1
Location 6p22.2      Physical location : 26.156.558 - 26.157.342
Synonym name
  • histone 1, H1e
  • linker histone 1 subtype 4
  • histone H1b
  • H1 histone family, member 4
  • Synonym symbol(s) H1.4, H1F4, dJ221C16.5, MGC116819, H1s-4, H1E
    DNA
    TYPE functioning gene
    SPECIAL FEATURE component of a cluster
    text clustered with core histone genes
    STRUCTURE 0.78 kb     1 Exon(s)    1 Copie(s)
    10 Kb 5' upstream gene genomic sequence study
    regulatory sequence Promoter (CAAT box) (TATA box)
    text structure highly conserved H1/AC box
    MAPPING cloned Y linked N status confirmed
    Physical map
    HIST1H1PS2 6p21.3 histone 1, H1, pseudogene 2 HIST1H1A 6p22-p21 histone 1, H1a HIST1H3A 6p21.3 histone 1, H3a HIST1H4A 6p21.3 histone 1, H4a HIST1H4B 6p21.3 histone 1, H4b HIST1H3B 6p21.3 histone 1, H3b HIST1H2AB 6p21.3 histone 1, H2ab HIST1H2BB 6p21.3 histone 1, H2bb HIST1H2APS5 6p21.3 histone 1, H2a, pseudogene 5 HIST1H3C 6p21.3 histone 1, H3c HIST1H1C 6p21.3 histone 1, H1c HFE 6p21.3 hemochromatosis HIST1H4C 6p21.3 histone 1, H4c HIST1H1T 6p21.3 histone 1, H1t HIST1H2BC 6p21.3 histone 1, H2bc HIST1H2AC 6p21.3 histone 1, H2ac HIST1H1E 6p21.3 histone 1, H1e HIST1H2BD 6p21.3 histone 1, H2bd HIST1H2BE 6p21.3 histone 1, H2be HIST1H4D 6p21.3 histone 1, H4d
    regionally located in the large histone gene cluster
    RNA
    TRANSCRIPTS type messenger
    text lacking the polyA tail but having instead a palindromic termination element
    identificationnb exonstypebpproduct
    ProteinkDaAAspecific expressionYearPubmed
    1 - 785 21.7 219 - 2016 26689747
    EXPRESSION
    Type
       expressed in (based on citations)
    organ(s)
    cell lineage
    cell lines
    fluid/secretion
    at STAGE
    PROTEIN
    PHYSICAL PROPERTIES
    STRUCTURE
    motifs/domains
  • a globular DNA-binding domain
  • a N terminal lysine-rich region, and N-terminal domain of H1 is an important determinant of affinity and specificity of H1-chromatin interactions
  • a C terminal region with oligopeptide repeats enriched in serine, proline, lysine
  • HOMOLOGY
    interspecies homolog to C.elegans f22f1.1
    ortholog to murine Hist1h1e
    Homologene
    FAMILY
  • histone H1/H5 family
  • CATEGORY regulatory , DNA associated , transcription factor
    SUBCELLULAR LOCALIZATION     intracellular
    intracellular,nucleus,chromatin/chromosome,nucleosome
    intracellular,nucleus,chromatin/chromosome,heterochromosome
    basic FUNCTION
  • involved in basal repression of gene expression
  • playing a role in the condensation of nucleosome chains into higher order structures
  • involved in epigenetic regulation
  • CELLULAR PROCESS nucleotide, chromatin organization, remodeling
    nucleotide, transcription, regulation
    PHYSIOLOGICAL PROCESS
    PATHWAY
    metabolism
    signaling
    a component
    INTERACTION
    DNA binding
    RNA
    small molecule
    protein
    cell & other
    REGULATION
    ASSOCIATED DISORDERS
    corresponding disease(s) OGID1
    Susceptibility
    Variant & Polymorphism
    Candidate gene
    Marker
    Therapy target
    ANIMAL & CELL MODELS