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FLASH GENE
Symbol HIST1H1C contributors: npt - updated : 20/11/2008
HGNC name histone cluster 1, H1c
HGNC id 4716
Location 6p21.3      Physical location : 26.055.968 - 26.056.699
Synonym name
  • histone 1, H1c
  • linker histone 1 subtype 2
  • histone H1d
  • H1 histone family, member 2
  • Synonym symbol(s) H1.2, H1F2, MGC:3992
    DNA
    TYPE functioning gene
    SPECIAL FEATURE component of a cluster
    STRUCTURE 0.78 kb     1 Exon(s)    1 Copie(s)
    10 Kb 5' upstream gene genomic sequence study
    regulatory sequence Promoter (CAAT box) (TATA box)
    text structure highly conserved H1/AC box
    MAPPING cloned Y linked N status confirmed
    Physical map
    SLC17A2 6p21.3 solute carrier family 17 (sodium phosphate), member 2 TRIM38 6p21.3 tripartite motif-containing 38 HIST1H1PS2 6p21.3 histone 1, H1, pseudogene 2 HIST1H1A 6p22-p21 histone 1, H1a HIST1H3A 6p21.3 histone 1, H3a HIST1H4A 6p21.3 histone 1, H4a HIST1H4B 6p21.3 histone 1, H4b HIST1H3B 6p21.3 histone 1, H3b HIST1H2AB 6p21.3 histone 1, H2ab HIST1H2BB 6p21.3 histone 1, H2bb HIST1H2APS5 6p21.3 histone 1, H2a, pseudogene 5 HIST1H3C 6p21.3 histone 1, H3c HIST1H1C 6p21.3 histone 1, H1c HFE 6p21.3 hemochromatosis
    regionally located in the large histone gene cluster
    RNA
    TRANSCRIPTS type messenger
    identificationnb exonstypebpproduct
    ProteinkDaAAspecific expressionYearPubmed
    1 - 732 21.2 213 - -
    EXPRESSION
    Type
       expressed in (based on citations)
    organ(s)
    tissue
    SystemTissueTissue level 1Tissue level 2LevelPubmedSpeciesStageRna symbol
    Blood / hematopoieticbone marrow   
    cell lineage
    cell lines
    fluid/secretion
    at STAGE
    PROTEIN
    PHYSICAL PROPERTIES basic
    STRUCTURE
    motifs/domains
  • a globular DNA-binding domain
  • a N terminal lysine-rich region
  • a C terminal region with oligopeptide repeats enriched in serine, proline, lysine
  • HOMOLOGY
    interspecies homolog to murine H1f2
    homolog to C.elegans m163.3
    Homologene
    FAMILY
  • histone H1/H5 family
  • CATEGORY regulatory , DNA associated , transcription factor
    SUBCELLULAR LOCALIZATION     intracellular
    intracellular,nucleus,chromatin/chromosome
    basic FUNCTION
  • involved in basal repression of gene expression
  • playing a role in the condensation of nucleosome chains into higher order structures
  • CELLULAR PROCESS nucleotide, chromatin organization, remodeling
    nucleotide, transcription, regulation
    PHYSIOLOGICAL PROCESS
    PATHWAY
    metabolism
    signaling
    a component
    INTERACTION
    DNA binding
    RNA
    small molecule
    protein
    cell & other
    REGULATION
    ASSOCIATED DISORDERS
    ANIMAL & CELL MODELS