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FLASH GENE
Symbol HIST1H1A contributors: npt - updated : 20/11/2008
HGNC name histone cluster 1, H1a
HGNC id 4715
Location 6p22.1      Physical location : 26.017.260 - 26.018.040
Synonym name
  • histone 1, H1a
  • linker histone 1 subtype 1
  • H1 histone family, member 1
  • Synonym symbol(s) H1.1, H1F1, HIST1, MGC126642, MGC138345
    DNA
    TYPE functioning gene
    SPECIAL FEATURE component of a cluster
    text cluster 55 histone genes (6 histone H1, 49 core histone )
    STRUCTURE 0.78 kb     1 Exon(s)    1 Copie(s)
    10 Kb 5' upstream gene genomic sequence study
    regulatory sequence Promoter (CAAT box) (TATA box)
    text structure highly conserved H1/AC box
    MAPPING cloned Y linked N status confirmed
    regionally located in the large histone gene cluster
    RNA
    TRANSCRIPTS type messenger
    text lacking the polyA tail but having instead a palindromic termination element
    identificationnb exonstypebpproduct
    ProteinkDaAAspecific expressionYearPubmed
    1 - 781 22 215 - -
    EXPRESSION
    Type restricted
       expressed in (based on citations)
    organ(s)
    SystemOrgan level 1Organ level 2Organ level 3Organ level 4LevelPubmedSpeciesStageRna symbol
    blood / hematopoieticthymus   specific
    Reproductivemale systemtestis  specific
    tissue
    SystemTissueTissue level 1Tissue level 2LevelPubmedSpeciesStageRna symbol
    Lymphoid    
    cells
    SystemCellPubmedSpeciesStageRna symbol
    Reproductivespermatid
    cell lineage
    cell lines
    fluid/secretion
    at STAGE
    PROTEIN
    PHYSICAL PROPERTIES basic
    STRUCTURE
    motifs/domains
  • a globular DNA-binding domain
  • a N terminal lysine-rich region
  • a C terminal region with oligopeptide repeats enriched in serine, proline, lysine
  • HOMOLOGY
    interspecies homolog to C.elegans f22f1.1
    homolog to murine Hist1h1a
    Homologene
    FAMILY
  • histone H1/H5 family
  • CATEGORY regulatory , DNA associated , transcription factor
    SUBCELLULAR LOCALIZATION     intracellular
    intracellular,nucleus,chromatin/chromosome
    basic FUNCTION
  • involved in basal repression of gene expression
  • playing a role in the condensation of nucleosome chains into higher order structures
  • modulating the potentiation/depotentiation of chromatin structure for transcription
  • CELLULAR PROCESS nucleotide, chromatin organization, remodeling
    nucleotide, transcription, regulation
    PHYSIOLOGICAL PROCESS
    PATHWAY
    metabolism
    signaling
    a component
    INTERACTION
    DNA binding
    RNA
    small molecule
    protein
    cell & other
    REGULATION
    ASSOCIATED DISORDERS
    ANIMAL & CELL MODELS