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FLASH GENE

Symbol

HIST1H1A

contributors: npt - updated : 20/11/2008

HGNC name	histone cluster 1, H1a
HGNC id	4715

FLASH GENE DNA RNA EXPRESSION PROTEIN DISORDER ANIMAL & CELL MODELS

Location	6p22.1      Physical location : 26.017.260 - 26.018.040
Synonym name	histone 1, H1a
	linker histone 1 subtype 1
	H1 histone family, member 1
Synonym symbol(s)	H1.1, H1F1, HIST1, MGC126642, MGC138345

DNA

TYPE	functioning gene
SPECIAL FEATURE	component of a cluster
text	cluster 55 histone genes (6 histone H1, 49 core histone )
STRUCTURE	0.78 kb     1 Exon(s)    1 Copie(s)

10 Kb 5' upstream gene genomic sequence study

regulatory sequence	Promoter (CAAT box) (TATA box)
text structure	highly conserved H1/AC box

MAPPING

cloned

Y

linked

N

status

confirmed

regionally located

in the large histone gene cluster

RNA

TRANSCRIPTS	type	messenger

text	lacking the polyA tail but having instead a palindromic termination element

identification nb exons type bp product Protein kDa AA specific expression Year Pubmed HIST1H1A 1 - 781 22 215 - -

EXPRESSION

Type	restricted

expressed in	(based on citations)
organ(s)	System Organ level 1 Organ level 2 Organ level 3 Organ level 4 Level Pubmed Species Stage Rna symbol blood / hematopoietic thymus       specific Reproductive male system testis     specific

tissue

System Tissue Tissue level 1 Tissue level 2 Level Pubmed Species Stage Rna symbol Lymphoid

cells

System Cell Pubmed Species Stage Rna symbol Reproductive spermatid

cell lineage

cell lines

fluid/secretion

at STAGE

PROTEIN

PHYSICAL PROPERTIES		basic
STRUCTURE

motifs/domains	a globular DNA-binding domain
	a N terminal lysine-rich region
	a C terminal region with oligopeptide repeats enriched in serine, proline, lysine

HOMOLOGY

interspecies	homolog to C.elegans f22f1.1
	homolog to murine Hist1h1a

Homologene

FAMILY

histone H1/H5 family

CATEGORY

regulatory , DNA associated , transcription factor

SUBCELLULAR LOCALIZATION	intracellular
	intracellular,nucleus,chromatin/chromosome

basic FUNCTION	involved in basal repression of gene expression
	playing a role in the condensation of nucleosome chains into higher order structures
	modulating the potentiation/depotentiation of chromatin structure for transcription

CELLULAR PROCESS	nucleotide, chromatin organization, remodeling
	nucleotide, transcription, regulation

PHYSIOLOGICAL PROCESS

PATHWAY

metabolism

signaling

a component

INTERACTION

DNA

binding

RNA

small molecule

protein

cell & other

REGULATION

ASSOCIATED DISORDERS

ANIMAL & CELL MODELS