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FLASH GENE
Symbol HIRIP3 contributors: npt/mct - updated : 10-01-2009
HGNC name HIRA interacting protein 3
HGNC id 4917
Location 16p11.2      Physical location : 30.004.310 - 30.007.412
DNA
TYPE functioning gene
SPECIAL FEATURE head to head
STRUCTURE 3.10 kb     7 Exon(s)
10 Kb 5' upstream gene genomic sequence study
MAPPING cloned Y linked N status provisional
Physical map
LOC388243 16 similar to carbonic anhydrase VA, mitochondrial precursor; carbonic anhydrase V, mitochondrial; carbonic dehydratase SPN 16p11.2 sialophorin (gpL115, leukosialin, CD43) QPRT 16q13 quinolinate phosphoribosyltransferase (nicotinate-nucleotide pyrophosphorylase (carboxylating)) FLJ35681 16p12.1 hypothetical protein FLJ35681 ZG16 16p12.1 zymogen granule protein 16 KIF22 16p11.2 kinesin family member 22 MAZ 16p11.2 MYC-associated zinc finger protein (purine-binding transcription factor) LOC112476 16p12.1 similar to lymphocyte antigen 6 complex, locus G5B; G5b protein; open reading frame 31 MGC4606 16p12.1 hypothetical protein MGC4606 MVP 16p11.2 major vault protein CDIPT 16p12.1 CDP-diacylglycerol--inositol 3-phosphatidyltransferase (phosphatidylinositol synthase) PSK-1 16p12.1 type I transmembrane receptor (seizure-related protein) KCTD13 16p11.2 potassium channel tetramerisation domain containing 13 LOC253982 16p12.1 hypothetical protein LOC253982 LOC124446 16p12.1 hypothetical protein BC017488 PSK 16p12.1 hypothetical protein BC017488 TAO1 16p11.2 hypothetical protein BC017488 HIRIP3 16q13 HIRA interacting protein 3 FLJ90652 16p12.1 hypothetical protein FLJ90652 DOC2A 16q13 double C2-like domains, alpha DKFZP434I2117 16p12.1 hypothetical protein DKFZp434I2117 ALDOA 16q22.2 aldolase A, fructose-bisphosphate PPP4C 16p12-p11 protein phosphatase 4 (formerly X), catalytic subunit TBX6 16p11.2 T-box 6 MGC10500 16p12.1 hypothetical protein MGC10500 MGC4171 16p12.1 hypothetical protein MGC4171 MAPK3 16p11.2 mitogen-activated protein kinase 3 CORO1A 16p11.2-q11.2 coronin, actin binding protein, 1A LOC339088 16p12.1 similar to My016 protein SULT1A3 16p11.2 sulfotransferase family, cytosolic, 1A, phenol-preferring, member 3 LOC387619 16 PI-3-kinase-related kinase SMG-1
RNA
TRANSCRIPTS type messenger
identificationnb exonstypebpproduct
ProteinkDaAAspecific expressionYearPubmed
7 - 2352 62 556 - Assrir (2007)
EXPRESSION
Type widely
   expressed in (based on citations)
organ(s)
SystemOrgan level 1Organ level 2Organ level 3Organ level 4LevelPubmedSpeciesStageRna symbol
Cardiovascularheart   highly
Lymphoid/Immunespleen   highly
 thymus   highly
cell lineage
cell lines
fluid/secretion
at STAGE
PROTEIN
PHYSICAL PROPERTIES
STRUCTURE
motifs/domains
  • seven N terminal WD-repeats
  • conjugated PhosphoP
    HOMOLOGY
    Homologene
    FAMILY
    CATEGORY regulatory , DNA associated
    SUBCELLULAR LOCALIZATION     intracellular
    intracellular,nucleus,chromatin/chromosome
    text nuclear throughout the cell cycle and excluded from condensed chromatin during mitosis
    basic FUNCTION
  • playing a role in chromatin assembly
  • member of the growing list of CSNK2A1 substrates with a possible role in chromatin metabolism
  • CELLULAR PROCESS
    PHYSIOLOGICAL PROCESS
    PATHWAY
    metabolism
    signaling
    a component
    INTERACTION
    DNA
    RNA
    small molecule
    protein
  • H2B, H3 binding
  • binding directly to the WD-repeat protein HIRA
  • interacting with and phosphorylated by the serine-threonine kinase CSNK2A1
  • cell & other
    REGULATION
    ASSOCIATED DISORDERS
    ANIMAL & CELL MODELS