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FLASH GENE
Symbol HIPK4 contributors: mct - updated : 13-10-2010
HGNC name homeodomain interacting protein kinase 4
HGNC id 19007
Location 19q13.2      Physical location : 40.885.178 - 40.896.094
Synonym symbol(s) FLJ32818
EC.number 2.7.11.1
DNA
TYPE functioning gene
STRUCTURE 10.92 kb     4 Exon(s)
MAPPING cloned Y linked N status provisional
RNA
TRANSCRIPTS type messenger
identificationnb exonstypebpproduct
ProteinkDaAAspecific expressionYearPubmed
4 - 2467 69.4 616 - - 18022393
EXPRESSION
Type restricted
   expressed in (based on citations)
organ(s)
SystemOrgan level 1Organ level 2Organ level 3Organ level 4LevelPubmedSpeciesStageRna symbol
Reproductivemale systemtestis  specific
Respiratorylung   moderately
tissue
SystemTissueTissue level 1Tissue level 2LevelPubmedSpeciesStageRna symbol
Connectiveadipose   
cell lineage
cell lines
fluid/secretion
at STAGE
PROTEIN
PHYSICAL PROPERTIES
STRUCTURE
motifs/domains
  • a serine/threonine protein kinase catalytic domain at its N-terminal end
  • one protein kinase domain
  • multiple putative serine/threonine- and tyrosine-specific phsophorylation sites
  • four high probability sumoylation sites
  • HOMOLOGY
    interspecies homolog to rattus Hipk4 (86.7pc)
    Homologene
    FAMILY
  • protein kinase superfamily
  • CMGC Ser/Thr protein kinase family
  • HIPK subfamily
  • CATEGORY enzyme
    SUBCELLULAR LOCALIZATION     intracellular
    intracellular,cytoplasm
    intracellular,nucleus,nucleoplasm,nuclear bodies,nuclear speckles
    text localizes to nucleus in response to certain stimuli
    basic FUNCTION
  • may have a serine/threonine kinase activity and act as a corepressor of transcription factors
  • phosphorylate several proteins, including homeodomain transcription factor NKX-1.2, androgen receptor and tumor suppressor TP53
  • having kinase activity important for the repressive function of TP53
  • implicated in regulating various intracellular signalings, such as TGF-beta, BMP, Notch and Wnt signaling
  • may function as cell-intrinsic determinants of cell migration in the retina
  • CELLULAR PROCESS protein, post translation
    PHYSIOLOGICAL PROCESS
    PATHWAY
    metabolism
    signaling
    a component
    INTERACTION
    DNA
    RNA
    small molecule nucleotide,
  • ATP binding
  • protein
    cell & other
    REGULATION
    ASSOCIATED DISORDERS
    ANIMAL & CELL MODELS