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FLASH GENE
Symbol HIPK3 contributors: mct - updated : 12-06-2018
HGNC name homeodomain interacting protein kinase 3
HGNC id 4915
Location 11p13      Physical location : 33.279.167 - 33.375.939
Synonym name
  • homolog of protein kinase YAK1
  • Fas-interacting serine/threonine-protein kinase
  • androgen receptor-interacting nuclear protein kinase
  • Synonym symbol(s) YAK1, PKY, DYRK6, FIST3, ANPK
    EC.number 2.7.11.1
    DNA
    TYPE functioning gene
    STRUCTURE 96.77 kb     17 Exon(s)
    10 Kb 5' upstream gene genomic sequence study
    MAPPING cloned Y linked N status provisional
    Physical map
    LOC387759 11 LOC387759 FLJ46154 11p14.1 FLJ46154 protein LOC341019 HCP25 11p13 cytochrome c, somatic pseudogene LOC120526 11p14.1 hypothetical protein LOC120526 FLJ25059 11p14.1 hypothetical protein FLJ25059 ELP4 11p13 elongation protein 4 homolog (S. cerevisiae) PAX6 11p13 paired box gene 6 (aniridia, keratitis) RCN1 11p13 reticulocalbin 1, EF-hand calcium binding domain LOC390105 11 similar to RIKEN cDNA 0610012H03 WT1 11p13 Wilms tumor 1 WIT-1 11p13 Wilms tumor associated protein LOC387760 11 LOC387760 GA17 11p13 LOC387760 RPL34P2 11p13 ribosomal protein L34 pseudogene 2 TMG4 11p13 transmembrane gamma-carboxyglutamic acid protein 4 FLJ21924 11p13 hypothetical protein FLJ21924 LOC91614 11p13 novel 58.3 KDA protein FLJ11336 11p13 hypothetical protein FLJ11336 PIGCP1 11p13-p12 phosphatidylinositol glycan, class C, pseudogene 1 CSTF3 11p13 cleavage stimulation factor, 3' pre-RNA, subunit 3, 77kDa LOC390107 11 similar to ribosomal protein S24 HIPK3 11p13 homeodomain interacting protein kinase 3 G2 11p13 G2 protein MGC34830 11p13 hypothetical protein MGC34830 CD59 11p13 CD59 antigen p18-20 (antigen identified by monoclonal antibodies 16.3A5, EJ16, EJ30, EL32 and G344) FBXO3 11p12 F-box only protein 3 LOC390108 11 similar to hypothetical protein MGC40611 LMO2 11p13 LIM domain only 2 (rhombotin-like 1) M11S1 11p13 membrane component, chromosome 11, surface marker 1 FLJ10774 11p13 N-acetyltransferase-like protein ABTB2 11p13 ankyrin repeat and BTB (POZ) domain containing 2 CAT 11p13 catalase ELF5 11p15-p13 E74-like factor 5 (ets domain transcription factor) EHF 11p12 ets homologous factor MMRP19 11p13 likely ortholog of mouse monocyte macrophage 19 PDHX 11p13 pyruvate dehydrogenase complex, component X CD44 11p13 CD44 antigen (homing function and Indian blood group system) SLC1A2 11p13-p12 solute carrier family 1 (glial high affinity glutamate transporter), member 2 DKFZP586H2123 11p13 DKFZP586H2123 protein FJX1 11p13 four jointed box 1 (Drosophila) TRIM44 11p12-14 tripartite motif-containing 44 LOC119722 11p13 similar to Keratin, type I cytoskeletal 18 (Cytokeratin 18) (K18) (CK 18)
    RNA
    TRANSCRIPTS type messenger
    identificationnb exonstypebpproduct
    ProteinkDaAAspecific expressionYearPubmed
    16 splicing 4680 - 1194 only in testis Venables 10640824
  • also called HIPK3 t
  • a 109 nucleotides extra exon
  • TRA2B regulates a number of splicing switches including activation of the human testis-specific exon HIPK3-T
  • 17 - 4743 - 1215 - - 10640824
  • also called HIPK3 fl
  • 21 extra amino acids in frame
  • EXPRESSION
    Type
       expressed in (based on citations)
    organ(s)
    SystemOrgan level 1Organ level 2Organ level 3Organ level 4LevelPubmedSpeciesStageRna symbol
    Cardiovascularheart   highly
    tissue
    SystemTissueTissue level 1Tissue level 2LevelPubmedSpeciesStageRna symbol
    Muscular    
    cell lineage
    cell lines overexpressed in multidrug resistant cell-lines
    fluid/secretion
    at STAGE
    PROTEIN
    PHYSICAL PROPERTIES
    STRUCTURE
    motifs/domains
  • protein kinase domain separated from the homeo proteins interacting domain
  • HOMOLOGY
    Homologene
    FAMILY
  • protein kinase superfamily
  • CMGC Ser/Thr protein kinase family
  • HIPK subfamily
  • CATEGORY enzyme
    SUBCELLULAR LOCALIZATION     intracellular
    intracellular,cytoplasm
    intracellular,nucleus,nucleoplasm,nuclear bodies,nuclear speckles
    basic FUNCTION
  • corepressor for homeo domain transcription factors
  • implicated in regulating various intracellular signalings, such as TGF-beta, BMP, Notch and Wnt signaling
  • may function as cell-intrinsic determinants of cell migration in the retina
  • HIPK1, HIPK2, HIPK3 share the mechanism of activation by tyrosine autophosphorylation with the closely related DYRK family (dual-specificity tyrosine phosphorylation regulated kinase)
  • CELLULAR PROCESS cell cycle
    PHYSIOLOGICAL PROCESS
    PATHWAY
    metabolism
    signaling
    a component
    INTERACTION
    DNA
    RNA
    small molecule
    protein
  • homeodomain interacting
  • with FRAP1 (control of its subcellular localization)
  • interacting with SFRS10
  • interacting with NR5A1 (enhanced NR5A1 activity, and c-Jun was required for the functional interaction of HIPK3 with NR5A1)
  • mediates cAMP signaling and stimulates NR5A1 activity to activate CYP11A1 transcription
  • cell & other
    REGULATION
    ASSOCIATED DISORDERS
    ANIMAL & CELL MODELS