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FLASH GENE
Symbol HIPK3 contributors: mct - updated : 12-06-2018
HGNC name homeodomain interacting protein kinase 3
HGNC id 4915
Location 11p13      Physical location : 33.279.167 - 33.375.939
Synonym name
  • homolog of protein kinase YAK1
  • Fas-interacting serine/threonine-protein kinase
  • androgen receptor-interacting nuclear protein kinase
  • Synonym symbol(s) YAK1, PKY, DYRK6, FIST3, ANPK
    EC.number 2.7.11.1
    DNA
    TYPE functioning gene
    STRUCTURE 96.77 kb     17 Exon(s)
    10 Kb 5' upstream gene genomic sequence study
    MAPPING cloned Y linked N status provisional
    RNA
    TRANSCRIPTS type messenger
    identificationnb exonstypebpproduct
    ProteinkDaAAspecific expressionYearPubmed
    16 splicing 4680 - 1194 only in testis Venables 10640824
  • also called HIPK3 t
  • a 109 nucleotides extra exon
  • TRA2B regulates a number of splicing switches including activation of the human testis-specific exon HIPK3-T
  • 17 - 4743 - 1215 - - 10640824
  • also called HIPK3 fl
  • 21 extra amino acids in frame
  • EXPRESSION
    Type
       expressed in (based on citations)
    organ(s)
    SystemOrgan level 1Organ level 2Organ level 3Organ level 4LevelPubmedSpeciesStageRna symbol
    Cardiovascularheart   highly
    tissue
    SystemTissueTissue level 1Tissue level 2LevelPubmedSpeciesStageRna symbol
    Muscular    
    cell lineage
    cell lines overexpressed in multidrug resistant cell-lines
    fluid/secretion
    at STAGE
    PROTEIN
    PHYSICAL PROPERTIES
    STRUCTURE
    motifs/domains
  • protein kinase domain separated from the homeo proteins interacting domain
  • HOMOLOGY
    Homologene
    FAMILY
  • protein kinase superfamily
  • CMGC Ser/Thr protein kinase family
  • HIPK subfamily
  • CATEGORY enzyme
    SUBCELLULAR LOCALIZATION     intracellular
    intracellular,cytoplasm
    intracellular,nucleus,nucleoplasm,nuclear bodies,nuclear speckles
    basic FUNCTION
  • corepressor for homeo domain transcription factors
  • implicated in regulating various intracellular signalings, such as TGF-beta, BMP, Notch and Wnt signaling
  • may function as cell-intrinsic determinants of cell migration in the retina
  • HIPK1, HIPK2, HIPK3 share the mechanism of activation by tyrosine autophosphorylation with the closely related DYRK family (dual-specificity tyrosine phosphorylation regulated kinase)
  • CELLULAR PROCESS cell cycle
    PHYSIOLOGICAL PROCESS
    PATHWAY
    metabolism
    signaling
    a component
    INTERACTION
    DNA
    RNA
    small molecule
    protein
  • homeodomain interacting
  • with FRAP1 (control of its subcellular localization)
  • interacting with SFRS10
  • interacting with NR5A1 (enhanced NR5A1 activity, and c-Jun was required for the functional interaction of HIPK3 with NR5A1)
  • mediates cAMP signaling and stimulates NR5A1 activity to activate CYP11A1 transcription
  • cell & other
    REGULATION
    ASSOCIATED DISORDERS
    ANIMAL & CELL MODELS