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FLASH GENE
Symbol HIPK1 contributors: mct - updated : 17-01-2018
HGNC name homeodomain interacting protein kinase 1
HGNC id 19006
Location 1p13.2      Physical location : 114.471.995 - 114.520.421
Synonym name
  • cDNA sequence,expressed in brain, 50kDa, related to serine/threonine protein kinase
  • homeodomain interacting protein kinase 1-like protein
  • nuclear body associated kinase 2b
  • Synonym symbol(s) KIAA0630, Myak, MGC26642, Nbak2, MGC33446, MGC33548
    EC.number 2.7.11.1
    DNA
    TYPE functioning gene
    STRUCTURE 48.43 kb     16 Exon(s)
    Genomic sequence alignment details
    10 Kb 5' upstream gene genomic sequence study
    MAPPING cloned Y linked N status provisional
    RNA
    TRANSCRIPTS type messenger
    identificationnb exonstypebpproduct
    ProteinkDaAAspecific expressionYearPubmed
    15 - 3438 116.6 1075 - 2015 25630557
    14 - 6802 87.2 816 - 2015 25630557
    16 - 8082 131 1210 - 2015 25630557
    15 - 6993 89.3 836 - 2015 25630557
    EXPRESSION
    Type
       expressed in (based on citations)
    organ(s)
    SystemOrgan level 1Organ level 2Organ level 3Organ level 4LevelPubmedSpeciesStageRna symbol
    Nervousbrain    
    cell lineage
    cell lines
    fluid/secretion
    at STAGE
    physiological period embryo
    Text expressed in the inner retina during late embryogenesis
    PROTEIN
    PHYSICAL PROPERTIES
    STRUCTURE
    motifs/domains
    HOMOLOGY
    intraspecies homolog to serine/threonine protein kinase
    Homologene
    FAMILY
  • protein kinase superfamily
  • CMGC Ser/Thr protein kinase family
  • HIPK subfamily
  • CATEGORY enzyme
    SUBCELLULAR LOCALIZATION     intracellular
    intracellular,cytoplasm,cytoskeleton,microtubule,centrosome
    intracellular,nucleus,nucleoplasm,nuclear bodies,nuclear speckles
    intracellular,nucleus,nucleoplasm,nuclear bodies,PML
    basic FUNCTION
  • phosphorylating MYB, thus repressing its ability to activate MIM1 in haematopoietic cells
  • contributes in a complex fashion to DVL1L1-dependent signaling activities during early vertebrate development
  • with HIPK2, are involved in regulation of eye size, lens formation and retinal lamination during late embryogenesis
  • may function as cell-intrinsic determinants of cell migration in the retina
  • is likely a novel kinase required for optimal B cell function
  • role of HIPK1, HIPK2 in connecting TGFB1 signaling pathway with the transcriptional programs critical for angiogenesis in early embryonic development
  • HIPK1, HIPK2, HIPK3 share the mechanism of activation by tyrosine autophosphorylation with the closely related DYRK family (dual-specificity tyrosine phosphorylation regulated kinase)
  • TGFB1I1 and HIPK1 assist MYB in recruiting the coactivator and acetyltransferase EP300 to chromatin
  • CELLULAR PROCESS
    PHYSIOLOGICAL PROCESS
    PATHWAY
    metabolism
    signaling
    a component
    INTERACTION
    DNA
    RNA
    small molecule
    protein
  • interacting with MYB
  • CTNNB1 signaling plays a dual role in controlling cell proliferation/differentiation in the brain, indicating that HIPK1 is the crucial interactor able to revert the outcome of CTNNB1 signaling in neural stem/progenitor cells of adult germinal niches
  • HIPK2 and HIPK1 restrict CNOT2-dependent mRNA decay
  • HIPK1-phosphorylated PAGE4 (HIPK1-PAGE4) potentiates JUN, whereas CLK2-phosphorylated PAGE4 (CLK2-PAGE4) attenuates JUN activity
  • TGFB1I1 is a novel interaction partner of the nuclear kinase HIPK1 and TGFB1I1, like HIPK1, also interacts with the transcription factor MYB
  • cell & other
    REGULATION
    ASSOCIATED DISORDERS
    corresponding disease(s)
    Other morbid association(s)
    TypeGene ModificationChromosome rearrangementProtein expressionProtein Function
    tumoral     --over  
    in breast cancer cells
    Susceptibility
    Variant & Polymorphism
    Candidate gene
    Marker
    Therapy target
    ANIMAL & CELL MODELS
  • B cell homeostatic defect in HIPK1-deficient (HIPK1(-/-)) mice