basic FUNCTION
| phosphorylating MYB, thus repressing its ability to activate MIM1 in haematopoietic cells |
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contributes in a complex fashion to DVL1L1-dependent signaling activities during early vertebrate development |
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with HIPK2, are involved in regulation of eye size, lens formation and retinal lamination during late embryogenesis |
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may function as cell-intrinsic determinants of cell migration in the retina |
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is likely a novel kinase required for optimal B cell function |
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role of HIPK1, HIPK2 in connecting TGFB1 signaling pathway with the transcriptional programs critical for angiogenesis in early embryonic development |
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HIPK1, HIPK2, HIPK3 share the mechanism of activation by tyrosine autophosphorylation with the closely related DYRK family (dual-specificity tyrosine phosphorylation regulated kinase) |
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TGFB1I1 and HIPK1 assist MYB in recruiting the coactivator and acetyltransferase EP300 to chromatin |