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FLASH GENE
Symbol HILPDA contributors: mct - updated : 23-01-2012
HGNC name hypoxia inducible lipid droplet-associated
HGNC id 28859
Location 7q32.1      Physical location : -
Genatlas name hypoxia-inducible protein 2
Synonym symbol(s) FLJ21076, MGC138388, C7orf68, HIG-2, HIG2
DNA
TYPE functioning gene
SPECIAL FEATURE arranged in tandem
STRUCTURE 2.59 kb     2 Exon(s)
MAPPING cloned Y linked N status provisional
RNA
TRANSCRIPTS type messenger
identificationnb exonstypebpproduct
ProteinkDaAAspecific expressionYearPubmed
2 - 1318 6 63 - Togashi (2005)
2 - 1432 6 63 - Togashi (2005)
EXPRESSION
Type widely
   expressed in (based on citations)
organ(s)
SystemOrgan level 1Organ level 2Organ level 3Organ level 4LevelPubmedSpeciesStageRna symbol
Digestivestomach   highly
Hearing/Equilibriumear   highly
Nervousbrainforebraincerebral cortexfrontal cortex 
Reproductivefemale systemovary  highly
cell lineage
cell lines
fluid/secretion
at STAGE
PROTEIN
PHYSICAL PROPERTIES
STRUCTURE
motifs/domains
HOMOLOGY
Homologene
FAMILY
CATEGORY regulatory
SUBCELLULAR LOCALIZATION extracellular
    intracellular
intracellular,cytoplasm,organelle,membrane
intracellular,cytoplasm,cytosolic,granule
basic FUNCTION
  • involved in the response to stress
  • implicated in canonical Wnt signaling, both as target and activator
  • decorates the hemimembrane of lipid droplets, whose number and size increase on hypoxic inhibition of fatty acid beta-oxidation, and colocalizes with the lipid droplet proteins adipophilin
  • could be detected in atherosclerotic arteries and fatty liver disease
  • CELLULAR PROCESS
    PHYSIOLOGICAL PROCESS
    PATHWAY
    metabolism
    signaling
    a component
    INTERACTION
    DNA
    RNA
    small molecule
    protein
  • with DBN1, and HILPDA, SETMAR, is a direct target of the SOX11 protein (are direct transcriptional targets of the SOX11 protein)
  • cell & other
    REGULATION
    ASSOCIATED DISORDERS
    corresponding disease(s)
    Other morbid association(s)
    TypeGene ModificationChromosome rearrangementProtein expressionProtein Function
    tumoral     --other  
    aberrantly expressed in cervical cancer (UCC) and endometrial cancer
    Susceptibility
    Variant & Polymorphism
    Candidate gene
    Marker
  • may be used as a marker for early detection of ovarian clear cell adenocarcinomas or for prediction of response to chemotherapy, but its expression does not predict survival of patients with clear cell adenocarcinoma
  • Therapy target
    ANIMAL & CELL MODELS