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FLASH GENE
Symbol HIKESHI contributors: mct - updated : 05-07-2017
HGNC name Hikeshi, heat shock protein nuclear import factor
HGNC id 26938
Corresponding disease
HLD13 hypomyelinating leukodystrophy-13
Location 11q14.2      Physical location : -
Synonym name
  • hypothetical protein HSPC138
  • protein C11orf73
  • lethal, Chr 7, Rinchik 6
  • chromosome 11 open reading frame 73
  • Synonym symbol(s) HSPC179, HSPC138, FLJ43020, L7RN6, C11orf73, HLD13, OPI10
    DNA
    TYPE functioning gene
    STRUCTURE 43.73 kb     5 Exon(s)
    MAPPING cloned Y linked N status provisional
    RNA
    TRANSCRIPTS type messenger
    identificationnb exonstypebpproduct
    ProteinkDaAAspecific expressionYearPubmed
    5 - 1187 - 197 - 2015 25760597
    6 - 1295 - 156 - 2015 25760597
    6 - 1225 - 158 - 2015 25760597
    5 - 1061 - 177 - 2015 25760597
    EXPRESSION
    Type widely
       expressed in (based on citations)
    organ(s)
    SystemOrgan level 1Organ level 2Organ level 3Organ level 4LevelPubmedSpeciesStageRna symbol
    Digestivepancreas exocrine   moderately
    Nervousbrain   highly
    Reproductivefemale systemovary  moderately
     female systemuterus  predominantly
     male systemprostate  moderately
    Skin/Tegumentskin   highly
    Urinarykidney   highly
    tissue
    SystemTissueTissue level 1Tissue level 2LevelPubmedSpeciesStageRna symbol
    Nervousperipherous   
    cell lineage
    cell lines
    fluid/secretion blood
    at STAGE
    PROTEIN
    PHYSICAL PROPERTIES
    STRUCTURE
    motifs/domains
  • N-terminal domain (NTD) consists of a jelly-roll/beta-sandwich fold structure which contains hydrophobic pockets involved in FG-Nup recognition
  • mono polymer homomer , dimer
    HOMOLOGY
    interspecies ortholog to rattus loc293103
    Homologene
    FAMILY
  • OPI10 family
  • CATEGORY receptor nuclear
    SUBCELLULAR LOCALIZATION extracellular
        intracellular
    intracellular,cytoplasm,cytosolic
    intracellular,nucleus,nucleoplasm
    basic FUNCTION
  • protects cells from heat shock-induced nuclear damage
  • HIKESHI-mediated nuclear import is essential for the attenuation and reversal of the thermal stress response in human cells
  • is a nuclear transport receptor required for cell survival after stress
  • CELLULAR PROCESS
    PHYSIOLOGICAL PROCESS
    PATHWAY
    metabolism
    signaling
    a component
    INTERACTION
    DNA
    RNA
    small molecule
    protein
  • mediates the nuclear import of the molecular chaperone HSP70
  • mediates heat-shock-induced nuclear import of 70&
  • 8197;kDa heat-shock proteins (Hsp70s) through interactions with FG-nucleoporins (FG-Nups), which are proteins in nuclear pore complexes (NPCs)
    cell & other
    REGULATION
    ASSOCIATED DISORDERS
    corresponding disease(s) HLD13
    Other morbid association(s)
    TypeGene ModificationChromosome rearrangementProtein expressionProtein Function
    tumoral     --over  
    in late stage of clear cell renal cell carcinoma (ccRCC)
    Susceptibility
    Variant & Polymorphism
    Candidate gene
    Marker
    Therapy target
    ANIMAL & CELL MODELS