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Symbol HIF1A contributors: mct/shn/pgu - updated : 09-10-2016
HGNC name hypoxia-inducible factor 1, alpha subunit (basic helix-loop-helix transcription factor)
HGNC id 4910
Location 14q23.2      Physical location : 62.162.118 - 62.214.977
Synonym name
  • member of PAS superfamily 1
  • member of PAS
  • ARNT interacting protein
  • ARNT-interacting protein
  • basic-helix-loop-helix-PAS protein MOP1
  • hypoxia-inducible factor 1 alpha isoform I.3
  • hypoxia-inducible factor 1-alpha
  • PAS domain-containing protein 8
  • class E basic helix-loop-helix protein 78
  • Synonym symbol(s) MOP1, HIF1, PASD8, HIF-1alpha, HIF1-ALPHA, bHLHe78
    TYPE functioning gene
    STRUCTURE 52.86 kb     15 Exon(s)
    10 Kb 5' upstream gene genomic sequence study
    MAPPING cloned Y linked N status confirmed
    Map cen - D14S1429 - D14S592 - HIF1A - D14S997 - D14S290 - qter
    TRANSCRIPTS type messenger
    text ARE elements in the 3'UTR of mRNA
    identificationnb exonstypebpproduct
    ProteinkDaAAspecific expressionYearPubmed
    15 splicing 4082 92.67 826 - 2005 15750626
  • a 15 exons variant
  • encoding for the longer product
  • 14 splicing 3955 82.62 735 - 2005 15750626
  • a 14 exons variant
  • lacking exon 14
  • 15 splicing 3979 - 850 - 2005 15750626
  • lacking both exons 11 and 12
  • protein without ODD domain, TAD and C terminal NLS motif
  • exhibiting neither the activity of transactivation nor hypoxia-induced nuclear translocation
    Type widely
       expressed in (based on citations)
    SystemOrgan level 1Organ level 2Organ level 3Organ level 4LevelPubmedSpeciesStageRna symbol
    Cardiovascularheart   highly
     vessel   moderately
    Digestiveesophagus   moderately
     mouth   highly
    Lymphoid/Immunethymus   moderately
    Reproductivemale systemtestis  moderately
    Respiratoryrespiratory tracttrachea  predominantly
    Urinarykidney   highly
    SystemTissueTissue level 1Tissue level 2LevelPubmedSpeciesStageRna symbol
    Connective   highly
    SystemCellPubmedSpeciesStageRna symbol
    cell lineage
    cell lines
    at STAGE
  • N-terminal basic helix-loop-helix (bHLH) domain
  • a stretch of approximately 300 amino acids, termed the PAS (Per - ARNT - Sim) domain containing two internal repeats, required for heterodimerization and DNA binding
  • a MAPK-docking domain (D-domain)
  • N and C terminal hypoxia-inducible transactivation domains (TADS)
  • a transcriptional inhibitory domain
  • an oxygen-dependent degradation domain (ODD)
  • conjugated PhosphoP , Acetylated
    mono polymer homomer , dimer
    interspecies ortholog to Hif1a, Rattus norvegicus
    ortholog to Hif1a, Mus musculus
    ortholog to HIF1A, Pan troglodytes
  • PAS superfamily
  • CATEGORY regulatory , transcription factor , protooncogene
    SUBCELLULAR LOCALIZATION     intracellular
  • shuttling of HIF1A between cytoplasm and nucleus is a complex process involving several members of the nuclear transport receptor family
  • basic FUNCTION
  • involved (essential) in cardiovascular development and systemic O2 homeostasis
  • essential for the regulation of glycolytic capacity in myeloid cells, has a role in regulation of survival and function in the inflammatory microenvironmen (
  • controlled through stability regulation of its alpha subunit, which is expressed under hypoxia but degraded under normoxia
  • regulating the expression of TWIST1 by binding directly to the hypoxia-response element (HRE) in the TWIST1 proximal promoter
  • promotes glycogen accumulation through regulating PPP1R3C expression under hypoxia, which revealed a novel metabolic adaptation of cells to hypoxia)
  • may be directly or indirectly required for normal development of the retinal vasculature, especially of the intermediate plexus (
  • HIF1A and EPAS1 play a critical role in cellular response to hypoxia
  • opposite roles of HIF1A and EPAS1 in the regulation of IL8 expression in endothelial cells
  • RUNX2, HIF1A, and VEGFA may regulate vascular angiogenesis spatially and temporally in the hypertrophic zone of the growth plate during endochondral bone formation
  • exerts a negative control over beta-cell differentiation
  • VHL-dependent regulation of HIF1A in the RPE is essential for normal RPE and iris development, ocular growth and vascular development in the anterior chamber, whereas VHL-dependent regulation of other downstream pathways is crucial for normal development and maintenance of the retinal vasculature
  • SP7 and and HIF1A cooperatively regulate VEGFA expression
  • HIF1A is a central regulator of collagen hydroxylation and secretion under hypoxia during bone development
  • active role of HIF1A and LACC1 in leprosy pathogenesis
  • CELLULAR PROCESS nucleotide, transcription, regulation
    metabolism carbohydrate
    signaling signal transduction
    a component
  • complexing with HIF2A and HIF2B (ARNT) for activation of genes involved in metabolism, angiogenesis, erythropo
  • esis and glycolysis through the recruitement of the CBP/p300 co-activator
  • heterodimerizing with MOP9
  • prostate-specific antigen gene promoter (
  • RNA
    small molecule
  • dimerize with ARNT (
  • MOP3 (
  • SRC-1 and transcription intermediary factor 2, TIF2 (
  • von Hippel-Lindau tumor suppressor protein, VHL
  • proteasome (prosome, macropain) subunit, alpha type, PSMA7 (
  • tumor suppressor TP53 (
  • Jun activation domain-binding protein-1, JAB1
  • period homolog 1 (Drosophila), PER1 (
  • functionally cooperates with c-Jun (
  • p53 binding protein homolog (mouse), MDM2 (
  • Brahma, Brm and Brahma/SWI2-related gene 1, Brg-1 (
  • SMT3 suppressor of mif two 3 homolog 1, SUMO1 (
  • cysteine-histidine-rich 1, CH1 (
  • retinoblastoma protein, pRB (
  • osteosarcoma amplified 9, endoplasmic reticulum lectin, OS9 (
  • pVHL-interacting deubiquitinating enzyme 2, VDU2 (
  • necdin homolog (mouse), NDN (
  • ARD1 (
  • MSF-A (
  • metastasis-associated protein 1, MTA1 (
  • testis specific gene antigen 10, TSGA10 (
  • beta-catenin (
  • spermidine/spermine-N(1)-acetyltransferase 2, SSAT2 (
  • RACGAP1 (HIF-1alpha function is negatively affected by its interaction with RACGAP1)
  • Nur77 (
  • signal transducer and activator of transcription3, STAT3 (
  • ELL and HIF1A are binding partners and can modulate the functions of each other in hypoxia (PMID;
  • Reptin
  • PPP3R1 binds to proteasome subunit alpha type 7 (PSMA7) and inhibits the transactivation activity of HIF1A via the proteasome pathway
  • MCM2, MCM5, MCM3 and MCM7
  • via its conserved D-domain, HIF1A could serve as a platform for MAPK1 in the nucleus of the cell, thus potentially facilitating phosphorylation of other MAPK1 substrates
  • HDAC4 regulates HIF1A protein acetylation and stability, via HIF1A N-terminal lysines
  • USP19 interacts with components of the hypoxia pathway including HIF1A and rescues it from degradation independent of its catalytic activity
  • up-regulated the mRNA and protein expressions of HIF1A- and HIF1-targeted genes, and ADM up-regulated the protein expressions of HIF1A through down-regulation of PH4TM mRNA expression and PH4TM activity
  • interrelationship between MUC1–HIF1A oncogenic signaling networks serves to facilitate tumor growth and metastasis
  • control of HIF1A by STAT1 and STAT3 is an important mechanism by which VEGFA expression is regulated in smooth muscle cells (SMC)
  • direct link between TGM2, NFKB1, and HIF1A, demonstrating TGM2 important role in cancer progression
  • SOCS3 is identified as a novel HIF1A target gene (HIF1A suppressed the expression of adiponectin through a SOCS3-STAT3 pathway)
  • HIF1A activates expression of genes encoding collagen prolyl (P4HA1 and P4HA2) and lysyl (PLOD2) hydroxylases
  • mechanistic link between HIF1A and CDK8, two potent oncogenes, in the cellular response to hypoxia
  • ESR1 plays a crucial role in decreasing HIF1A protein levels in osteoclasts, even in hypoxic conditions (
  • HEXIM1 attenuated the interaction of HIF1A with HDAC1 (histone deacetylase 1), resulting in acetylation of HIF1A
  • HIF1A is transcriptional regulator of ADORA2B during acute lung injury
  • positively regulates the induction of NFAT5 and HSPA4 by placental hypoxia
  • MME up-regulation might be an adaptive response to hypoxia, which was mediated by HIF1A binding to HDAC1 at the early stage of hypoxia
  • HIF1A directly regulated LEPR expression in pancreatic cancer, which might be a valuable therapeutic target for pancreatic cancer
  • deubiquitinase OTUD7B regulates HIF1A homeostasis
  • VHL mediate the ubiquitination of HIF1A in the nuclear compartment prior to HIF1A exportation to the cytoplasm, and VHL dynamic nuclear-cytoplasmic trafficking is indicated to be involved in the process of HIF1A degradation
  • regulation of ATP13A2 via EGLN1-HIF1A signaling is critical for cellular iron homeostasis
  • role of ALDOA in pancreatic cancer might attribute to its regulation of MYC, HIF1A and NFE2L2 (Nuclear Factor, Erythroid 2-Like 2), which were key regulators of glycolysis and antioxidant response control
  • HIF1A acts as a direct repressor of aspartate biosynthesis involving the suppression of several key aspartate-producing proteins, including cytosolic GOT1 and mitochondrial GOT2
  • cell & other
    activated by p42/p44 MAPK (
    induced by hypoxia-inducible
    inhibited by p14ARF
    MCM3 (
    valproic acid and trapoxin (
    repressed by estrogen in osteoclasts and loss of estrogen stabilizes HIF1A in those cells, which in turn activates bone resorption and promotes bone loss
    Other rapidly degraded by proteasome under normoxic conditions
    regulated by von Hippel-Lindau tumour suppressor protein, VHL (
    targeted by VALand
    pVHL-interacting protein functions as a negative regulator of HIF-1alpha transactivation (
    945; protein levels downregulated by MCM7 (
    regulated by proteasome (prosome, macropain) subunit, alpha type, 7, PSMA7 (
    PARP1 as a transcriptional coactivator of HIF-1-dependent gene expression during tumor progression (
    epigenetic regulation of CD34 and HIF1A expression during the differentiation of mast cells
    corresponding disease(s)
    Susceptibility to Leprosy
    Variant & Polymorphism SNP rs142179458 increasing the risk of Leprosy
    Candidate gene
  • cell free plasma expressions of CDKN1A and HIF1A were more prevalent in pregnancies complicated by hypoxia and/or IUGR
  • Therapy target
    diabetetype 2 
    inhibitors of HIF1A have potential utility for the treatment of type 2 diabetes
    inhibitors of HIF1A have potential utility for the treatment of obesity
    represents a promising therapeutic target in osteoporosis
    ALDOA-HIF1A axis may provide a new therapeutic target for metastatic lung cancer treatment
  • Hif1a-/- mouse embryos with complete deficiency of HIF-1alpha due to homozygosity for a null allele at the Hif1a locus die at midgestation, with multiple cardiovascular malformations and mesenchymal cell death (
  • transgenic mice expressing constitutively active HIF-1alpha in epidermis displayed hypervascularity with 66% increase in dermal capillaries, a 13-fold elevation of total vascular endothelial growth factor (VEGF) expression, and a six- to ninefold induction of each VEGF isoform (
  • partialHIF-1 alpha deficiency has a dramatic effect on carotid body neural activity and ventilatory adaptation to chronic hypoxia in Hif1a(+/-) mice (
  • neural cell-specific HIF-1alpha-deficient mice exhibit hydrocephalus accompanied by a reduction in neural cells and an impairment of spatial memory (
  • skeletal-muscle HIF-1alpha knockout mice have an altered exercise endurance (
  • mice lacking HIF-1alpha in their myeloid cell lineage showed decreased bactericidal activity and failed to restrict systemic spread of infection from an initial tissue focus (
  • mice lacking HIF-1alpha in osteoblasts had impaired angiogenesis and bone healing (
  • HIF-1alpha- and TWIST-null mice show similarities in their phenotypes (Yang, 2008)