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FLASH GENE
Symbol HHEX contributors: mct/npt/pgu - updated : 12-05-2010
HGNC name hematopoietically expressed homeobox
HGNC id 4901
Location 10q23.33      Physical location : 94.449.680 - 94.455.406
Synonym name
  • proline-rich homeodomain containing transcription factor
  • homeobox protein PRH
  • homeobox protein HEX
  • Synonym symbol(s) PRHX, HLX, HMPH, PRH, HOX11L-PEN, HEX
    DNA
    TYPE functioning gene
    STRUCTURE 5.73 kb     4 Exon(s)
    10 Kb 5' upstream gene genomic sequence study
    MAPPING cloned Y linked N status provisional
    Physical map
    HTR7 10q22-q24 5-hydroxytryptamine (serotonin) receptor 7 (adenylate cyclase-coupled) RPP30 10q23.32-q23.33 ribonuclease P (30kD) ANKRD1 10q23.33 ankyrin repeat domain 1 (cardiac muscle) LOC387701 10 LOC387701 MGC34007 10q23.33 hypothetical protein MGC34007 MGC16202 10q23.33 hypothetical protein MGC16202 FLJ37306 10q23.32 hypothetical protein FLJ37306 LOC387702 10 similar to hypothetical protein FLJ25224 PPP1R3C 10q23-q24 protein phosphatase 1, regulatory (inhibitor) subunit 3C LOC389995 10 similar to Glyceraldehyde 3-phosphate dehydrogenase, liver (GAPDH) TNKS2 10q23.3 tankyrase, TRF1-interacting ankyrin-related ADP-ribose polymerase 2 C10orf13 10q23.33 chromosome 10 open reading frame 13 BTAF1 10q22-q23 BTAF1 RNA polymerase II, B-TFIID transcription factor-associated, 170kDa (Mot1 homolog, S. cerevisiae) CPEB3 10q23.33 cytoplasmic polyadenylation element binding protein 3 FLJ20445 10q23.33 hypothetical protein FLJ20445 LOC389996 10 similar to MAP/microtubule affinity-regulating kinase 2 isoform a; ELKL motif kinase 1; ELKL motif kinase IDE 10q24 insulin-degrading enzyme KIF11 10q24.1 kinesin family member 11 LOC283014 10q23.33 similar to eukaryotic translation initiation factor 2, subunit 2 beta, 38kDa; eukaryotic translation initiation factor 2, subunit 2 (beta, 38kD ); eukaryotic initiation factor 2-beta HHEX 10q24 hematopoietically expressed homeobox SEC15L1 10q23.33 SEC15-like 1 (S. cerevisiae) CYP26C1 10q23.33 cytochrome P450, family 26, subfamily C, polypeptide 1 CYP26A1 10q23-q24 cytochrome P450, family 26, subfamily A, polypeptide 1 LOC389997 10 similar to Saccharomyces cerevisiae Nip7p homolog LOC387703 10 similar to ATP-dependent DNA helicase II, 70 kDa subunit (Lupus Ku autoantigen protein p70) (Ku70) (70 kDa subunit of Ku antigen) (Thyroid-lupus autoantigen) (TLAA) (CTC box binding factor 75 kDa subunit) (CTCBF) (CTC75) LOC389998 10 similar to 60S ribosomal protein L17 (L23) FER1L3 10q23.3 fer-1-like 3, myoferlin (C. elegans) C10orf3 10q23.33 chromosome 10 open reading frame 3 GPR120 10q23.33 G protein-coupled receptor 120 RBP4 10q24 retinol binding protein 4, plasma PDE6C 10q24 phosphodiesterase 6C, cGMP-specific, cone, alpha prime C10orf4 10q23.33 chromosome 10 open reading frame 4 LGI1 10q24 leucine-rich, glioma inactivated 1 FLJ33990 10q23.33 hypothetical protein FLJ33990 PSMD4P2 10q23.33 proteasome (prosome, macropain) 26S subunit, non-ATPase, 4, pseudogene 2 PLCE1 10q23 phospholipase C, epsilon 1 AD24 10q23.33 AD24 protein KIAA0608 10q23.33 KIAA0608 protein HELLS 10q23-q24 helicase, lymphoid-specific CYP2C18 10q24 cytochrome P450, family 2, subfamily C, polypeptide 18 CYP2C19 10q24 cytochrome P450, family 2, subfamily C, polypeptide 19 CYP2C9 10q24.1 cytochrome P450, family 2, subfamily C, polypeptide 9 CYP2C8 10q23.33 cytochrome P450, family 2, subfamily C, polypeptide 8 LOC387705 10 LOC387705 LOC142827 10q24.1 similar to Hypothetical protein MGC56918
    RNA
    TRANSCRIPTS type messenger
    identificationnb exonstypebpproduct
    ProteinkDaAAspecific expressionYearPubmed
    4 - 1772 - 270 - 1994 7911091
    EXPRESSION
    Type widely
       expressed in (based on citations)
    organ(s)
    SystemOrgan level 1Organ level 2Organ level 3Organ level 4LevelPubmedSpeciesStageRna symbol
    Digestiveliver    
    Endocrinethyroid   highly
    Lymphoid/Immunelymph node   highly
    Respiratoryrespiratory tractlarynx  highly
     respiratory tracttrachea  highly
    cell lineage hematopoietic cells
    cell lines promyelocytic leukemia cell lines
    fluid/secretion
    at STAGE
    PROTEIN
    PHYSICAL PROPERTIES
    STRUCTURE
    motifs/domains
  • an Eh-1 (Engrailed homology) motif present within the N-terminal transcription repression domain of PRH mediates binding to Groucho/TLE proteins and enables co-repression
  • an homeobox DNA-binding domain
  • HOMOLOGY
    interspecies homolog to murine Hhex
    intraspecies homolog to HOX11
    Homologene
    FAMILY
  • homeobox transcription factor family
  • CATEGORY DNA associated , transcription factor
    SUBCELLULAR LOCALIZATION     intracellular
    intracellular,nucleus
    text
  • when GPC3 binds to CD81, CD81-HHEX binding decreases, resulting in nuclear translocation of HHEX and transcriptional repression)
  • basic FUNCTION
  • may be playing a role in hematopoietic differentiation
  • may play a role in differentiation of the epithelial breast cell
  • regulates the nuclear retention of TLE proteins during cellular fractionation
  • regulates transcription by binding to specific DNA sequences and regulates mRNA transport by binding to translation initiation factor EIF4E
  • T lineage oncogene when misexpressed in hematopoietic precursor cells
  • homeodomain factor expressed in multiple endoderm-derived tissues, like the liver, where it is essential for proper development
  • recently implicated in pancreas development and the regulation of insulin secretion
  • plays multiple roles in the control of gene expression during embryonic development and in the adult
  • key regulator of the VEGF signaling pathway, playing an important role in tumorigenesis and leukemogenesis
  • HHEX and CER1 mediate the SOX17 pathway for cardiac mesoderm formation in embryonic stem cells
  • CELLULAR PROCESS nucleotide, transcription
    PHYSIOLOGICAL PROCESS
    PATHWAY
    metabolism
    signaling
    a component
    INTERACTION
    DNA
    RNA
    small molecule
    protein
  • interaction between HHEX (hematopoietically expressed homeobox) and SOX13 that modulates Wnt/TCF pathway activity (this interaction may contribute to control Wnt/TCF signaling in the early embryo)
  • binds directly to the promoter regions of the VEGFA, FLT1, and KDR genes and that in each case, represses transcription
  • interacts with the beta subunit of CK2 in cells (CK2 phosphorylates HHEX, and CK2 phosphorylation of the HHEX homeodomain functions as a reversible switch for DNA binding)
  • CD81-HHEX binding (when GPC3 binds to CD81, CD81-HHEX binding decreases, resulting in nuclear translocation of HHEX and transcriptional repression)
  • cell & other
    REGULATION
    ASSOCIATED DISORDERS
    corresponding disease(s)
    Other morbid association(s)
    TypeGene ModificationChromosome rearrangementProtein expressionProtein Function
    tumoral     --over  
    in T-cell-derived lymphomas
    Susceptibility to type 2 diabetes
    Variant & Polymorphism other
  • poymorphisms increasing the risk of type 2 diabetes
  • variant (rs5015480) near HHEX associated with the susceptibility of T2DM in females, but not in males (
  • Candidate gene
    Marker
    Therapy target
    ANIMAL & CELL MODELS