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FLASH GENE
Symbol HGFAC contributors: mct/npt - updated : 17-08-2007
HGNC name HGF activator
HGNC id 4894
Location 4p16.2      Physical location : 3.443.725 - 3.451.211
Synonym name hepatocyte growth factor activator precursor
Synonym symbol(s) HGFAP, HGFA, MGC138395, MGC138397
EC.number 3.1.21.-
DNA
TYPE functioning gene
STRUCTURE 7.49 kb     14 Exon(s)
10 Kb 5' upstream gene genomic sequence study
MAPPING cloned Y linked   status confirmed
Map pter - D4S3034 - D4S412 - HGFAC - D4S876 - D4S2957 - cen
Authors UCSC (2009)
Physical map
MGC4701 4p16.3 hypothetical protein MGC4701 MXD4 4p16.3 MAX dimerization protein 4 KIAA1643 4p16.3 KIAA1643 protein LOC339985 4p16.3 hypothetical gene supported by BC010180 RNF4 4p16.3 ring finger protein 4 C4orf8 4p16.3 chromosome 4 open reading frame 8 TNIP2 4p16.3 TNFAIP3 interacting protein 2 LOC389196 4 LOC389196 SH3BP2 4p16.3 SH3-domain binding protein 2 ADD1 4p16.3 adducin 1 (alpha) TETRAN 4p16.3 tetracycline transporter-like protein C4orf9 4p16.3 chromosome 4 open reading frame 9 GPRK2L 4p16.3 G protein-coupled receptor kinase 2-like (Drosophila) HD 4p16.3 huntingtin (Huntington disease) LOC345222 4p16.3 hypothetical gene supported by BC043530 RGS12 4p16.3 regulator of G-protein signalling 12 HGFAC 4p16.3 HGF activator FLJ33718 4p16.3 hypothetical protein FLJ33718 LOC391612 4 similar to hypothetical protein MGC45871 LRPAP1 4p16.3 low density lipoprotein receptor-related protein associated protein 1 FLJ35424 4p16.3 hypothetical protein FLJ35424 ADRA2C 4p16.3-p15 adrenergic, alpha-2C-, receptor LOC391613 4 similar to mannosyltransferase LOC196483 LOC391614 4 similar to Alkaline sphingomyelinase LOC391615 4 similar to 40S RIBOSOMAL PROTEIN S3A (V-FOS TRANSFORMATION EFFECTOR PROTEIN) LOC391616 4 similar to chromosome 11 open reading frame2; chromosome 11 open reading frame2 OR7E43P 4p16.1 olfactory receptor, family 7, subfamily E, member 43 pseudogene OTOP1 4p16.2 otopetrin 1 MGC13159 4p16.2 hypothetical protein MGC13159 LYAR 4p16.2 hypothetical protein FLJ20425 ZNF509 4p16.2 zinc finger protein 509 D4S234E 4p16.3 DNA segment on chromosome 4 (unique) 234 expressed sequence STX18 4p16.2 syntaxin 18
RNA
TRANSCRIPTS type messenger
identificationnb exonstypebpproduct
ProteinkDaAAspecific expressionYearPubmed
14 - 2038 70.7 655 - Mukai (2008)
EXPRESSION
Type restricted
   expressed in (based on citations)
organ(s)
SystemOrgan level 1Organ level 2Organ level 3Organ level 4LevelPubmedSpeciesStageRna symbol
Digestiveliver    
Nervousbrain    
Reproductivefemale systembreastmammary gland  
 female systemovary   
cell lineage
cell lines
fluid/secretion
at STAGE
PROTEIN
PHYSICAL PROPERTIES
STRUCTURE
motifs/domains
  • multiple putative domains homolog to those observed in coagulation factor XII
  • two Ig-like domain
  • a fibronectin type I, fibronectin type II domains
  • a kringle domain
  • a protease domain
  • a C terminal serine protease domain
    • isoforms Precursor
    HOMOLOGY
    Homologene
    FAMILY
  • peptidase S1 family
    • CATEGORY enzyme , signaling growth factor
    SUBCELLULAR LOCALIZATION extracellular
    text secreted as a single chain
    basic FUNCTION
  • hepatocyte growth factor activator
  • serine protease involved in the endoproteolytic processing of HGF
  • circulates as a zymogen (pro-HGFA) and is activated in response to tissue injury (Mukai 2008)
    • CELLULAR PROCESS cell life, proliferation/growth
    PHYSIOLOGICAL PROCESS
    PATHWAY
    metabolism
    signaling
    a component
    INTERACTION
    DNA
    RNA
    small molecule
    protein
  • interacting with KLK4, KLK5 (KLK4 and KLK5 mediate HGFA-induced activation of pro-HGF/SF within tumor tissue, which may thereafter trigger a series of events leading to tumor progression via the MET receptor) (Mukai 2008)
    • cell & other
    REGULATION
    ASSOCIATED DISORDERS
    corresponding disease(s)
    Other morbid association(s)
    TypeGene ModificationChromosome rearrangementProtein expressionProtein Function
    tumoral     --over  
    in multiple myeloma cells which catalyze hepatocyte growth factor (HGF) activation by secreting the serine protease HGF-activator
    Susceptibility
    Variant & Polymorphism
    Candidate gene
    Marker
    Therapy target
    ANIMAL & CELL MODELS