protein
| HAMP (positively regulating hepcidin expression) |
|
BMP coreceptor, whose enhancement of BMP signaling is important in regulating hepcidin expression and iron metabolism |
|
interaction with neogenin (NEO1) resulting in iron accumulation in embryonic kidney cells |
|
co-receptor for BMP6 and BMP6 and HFE2 act coordinately to induce hepcidin expression |
|
interacting with BMP2, BMP4, BMPR1B, BMP6 |
|
TMPRSS6 regulates the levels of membrane-bound HFE2 in hepatocytes by binding to and cleaving HFE2 into an inactive soluble form that is released from cells |
|
also interacts with NEO1, a ubiquitously expressed transmembrane protein with multiple functions |
|
TMPRSS6 suppresses the expression of hepatic HAMP, an iron regulatory hormone, by cleaving membrane HFE2 into an inactive form |
|
TMPRSS6 regulates HAMP expression by cleaving hemojuvelin (HFE2), a bone morphogenetic protein (BMP) coreceptor in the hepcidin regulatory pathway |
|
HFE2 can simultaneously bind to both BMP2 and the ubiquitously expressed cell surface receptor NEO1 |
|
NEO1 acts as a scaffold to facilitate assembly of the HFE2·BMP·BMP receptor complex to induce hepcidin expression ( |