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FLASH GENE

Symbol

HEXIM2

contributors: np/ - updated : 28-06-2006

HGNC name	hexamthylene bis-acetamide inducible 2
HGNC id	28591

FLASH GENE DNA RNA EXPRESSION PROTEIN DISORDER ANIMAL & CELL MODELS

Location	17q21.31      Physical location : 43.238.263 - 43.247.406
Synonym name	MAQ1 paralog
	protein HEXIM2
Synonym symbol(s)	FLJ32384, L3

DNA

TYPE	functioning gene
STRUCTURE	9.14 kb     4 Exon(s)

MAPPING

cloned

Y

linked

N

status

provisional

RNA

TRANSCRIPTS	type	messenger

identification nb exons type bp product Protein kDa AA specific expression Year Pubmed NM_144608 4 - 1330 NP_653209 32.3 286 - -

EXPRESSION

Type

constitutive of

expressed in	(based on citations)
organ(s)	System Organ level 1 Organ level 2 Organ level 3 Organ level 4 Level Pubmed Species Stage Rna symbol Endocrine parathyroid         Reproductive female system ovary       Skin/Tegument skin         Visual eye

tissue

System Tissue Tissue level 1 Tissue level 2 Level Pubmed Species Stage Rna symbol Muscular

cell lineage
cell lines
fluid/secretion	lymph

at STAGE

PROTEIN

PHYSICAL PROPERTIES

STRUCTURE

motifs/domains

mono polymer

homomer , heteromer , dimer , oligo

HOMOLOGY

Homologene

FAMILY

HEXIM family

CATEGORY

regulatory , RNA associated

SUBCELLULAR LOCALIZATION	intracellular
	intracellular,cytoplasm
	intracellular,nucleus

basic FUNCTION	transcriptional repressor activity
	regulator of CCNT1 activity
	fonctionally and quantitatively compensate the lack of HEXIM1

CELLULAR PROCESS

nucleotide, transcription, regulation

PHYSIOLOGICAL PROCESS

PATHWAY

metabolism

signaling

a component

component of a complex made of CCNT1, 7SK RNA and HEXIM1 or HEXIM2

INTERACTION

DNA

RNA	7SK RNA binding

small molecule

protein

binding CCNT1 (positive transcriptional elongation factor b), and having regulated association with CCNT1

cell & other

REGULATION

ASSOCIATED DISORDERS

ANIMAL & CELL MODELS