Selected-GenAtlas references SOURCE GeneCards NCBI Gene Swiss-Prot Ensembl
HGNC UniGene Nucleotide OMIM UCSC
Home Page
Symbol HEXIM1 contributors: mct/pgu - updated : 06-03-2018
HGNC name hexamethylene bis-acetamide inducible 1
HGNC id 24953
Location 17q21.31      Physical location : 43.224.683 - 43.229.467
Synonym name
  • menage a quatre protein 1
  • cardiac lineage protein 1
  • estrogen down regulated gene 1
  • HMBA-inducible
  • protein HEXIM1
  • Synonym symbol(s) CLP1, HIS1, MAQ1, EDG1, FLJ13562
    TYPE functioning gene
    SPECIAL FEATURE head to head
    STRUCTURE 4.79 kb     1 Exon(s)
    MAPPING cloned Y linked N status provisional
    TRANSCRIPTS type messenger
    identificationnb exonstypebpproduct
    ProteinkDaAAspecific expressionYearPubmed
    1 - 4785 40.6 359 - 2010 20453883
    Type restricted
       expressed in (based on citations)
    SystemOrgan level 1Organ level 2Organ level 3Organ level 4LevelPubmedSpeciesStageRna symbol
    Reproductivefemale systembreastmammary gland  
     female systemplacenta   
    SystemTissueTissue level 1Tissue level 2LevelPubmedSpeciesStageRna symbol
    cell lineage
    cell lines
    at STAGE
    physiological period fetal
    Text eye
  • a central PYNT motif required to inhibit the cyclin-dependent kinase CDK9
  • C-terminal region critical for cardiovascular development, C-terminal coiled-coil domain that recognizes the Cyclin T subunit of CCNT1
  • mono polymer homomer , heteromer , dimer , oligo
    interspecies homolog to murine Hexim1 (86.0pc)
  • HEXIM family
  • CATEGORY regulatory , RNA associated
    SUBCELLULAR LOCALIZATION     intracellular
    basic FUNCTION
  • sequestering CCNT1 into an inactive 7SK/HEXIM1/CCNT1 small nuclear ribonucleic acid particle for inhibition of transcription and, consequently, cell proliferation
  • dual roles in transcriptional regulation: inhibition of transcriptional elongation dependent on 7SK RNA and positive transcription elongation factor b and interference with the sequence-specific transcription factor GR via a direct protein-protein interaction
  • coregulator of ERalpha transcriptional activity
  • playing an inhibitory role in NF-kappa B dependent gene expression in vascular smooth muscle cells
  • possible role for HEXIM1 ubiquitination in the regulation of CCNT1 activity
  • involved in other nuclear and cytoplasmic processes besides controlling CDK9
  • may act as a gene-selective transcriptional regulator via direct interaction with certain transcriptional regulators including GR and contribute to fine-tuning of, for example, glucocorticoid-mediated biological responses
  • inhibits phosphorylation of RNA polymerase II by interacting with the positive transcription elongation factor CCNT1, regulating the transcription elongation
  • regulates estrogen-induced VEGF transcription through inhibition of estrogen receptor-alpha recruitment to the VEGF promoter
  • having a inhibitory role during angiogenesis and a role for HEXIM1 in cancer progression
  • potential for HEXIM1 to indirectly act on multiple cell types to suppress metastatic cancer
  • crucial role for the HEXIM1/CCNT1 pathway in the regulation of satellite cell–mediated muscle regeneration
  • plays a critical role in the inhibition of the androgen receptor by anti-androgens
  • might be a novel factor involved in maintaining whole-body energy balance
  • transcription elongation regulator, acting as a melanoma tumor suppressor that responds to nucleotide stress
  • plays an important role in inhibiting cancer cell-specific gene transcription while also facilitating anti-cancer gene expression, and in coupling nucleotide metabolism with transcriptional regulation in melanoma
  • acts as a tumor suppressor and is involved in the regulation of innate immunity
  • in addition to its action on CCNT1, plays a role in a variety of different mechanisms: it controls the stability of transcription factor components and assists binding of transcription factors to their targets
  • CELLULAR PROCESS cell life, differentiation
    cell life, proliferation/growth
    nucleotide, transcription, elongation
    nucleotide, transcription, regulation
    a component
  • part of CCNT1/HEXIM1/RN7SK complexes (RN7SK is released from CCNT1/HEXIM1/RN7SK complexes upon an arrest in transcription and physiological stimulations such as cardiac hypertrophy, leading to CCNT1 activation)
  • component of a distinct complex made of HEXIM1 and NR3C1
  • ribonuclear complex built around HEXIM1 and the long non-coding RNA NEAT1that regulates the innate immune response to DNA viruses
  • CCNT1 is stored in the 7SK ribonucleoprotein (RNP) that contains the three nuclear proteins HEXIM1, LARP7, and MEPCE
    RNA binding snRNA 7SK
    small molecule
  • associates with glucocorticoid receptor (NR3C1) to suppress glucocorticoid-inducible gene activation (the hinge region of NR3C1 is essential for its interaction with HEXIM1)
  • interacting with ERalpha via the cyclin T1
  • interacting with the p65 subunit of NF-kappa B
  • binding CCNT1 (positive transcriptional elongation factor b), and having regulated association with CCNT1
  • targets a repeated GAUC motif in the riboregulator of transcription RN7SK and promotes base pair rearrangements
  • BRD4 and HEXIM1 proteins interact with CCNT1 at or very near speckle domain
  • mechanism of release of CCNT1 and HEXIM1 from the RN7SK snRNP by viral and cellular activators includes a conformational change in RN7SK
  • interacts with two key TP53 regulators, nucleophosmin and double minute-2 protein (HDM2), implying a possible connection between HEXIM1 and the TP53 signaling pathway
  • role of HEXIM1 in regulating human pluripotent stem cells (hPSCs) fate through a CCNT1-independent pathway
  • HEXIM1 attenuated the interaction of HIF1A with HDAC1 (histone deacetylase 1), resulting in acetylation of HIF1A
  • binding of HEXIM1 protein triggers the inhibition of the kinase complex CCNT1, a key actor of the switch from paused transcription to elongation
  • PPM1G phosphatase directly binds RN7SK RNA and the kinase inhibitor HEXIM1 once CCNT1 has been released from the RN7SK snRNP
  • binds to the CDK9 catalytic site to inhibit CCNT1
  • inhibit androgen receptor transcriptional activity
  • cell & other
    induced by by hexamethylene-bis-acetamide in vascular smooth muscle cells
    repressed by by estrogens
    corresponding disease(s)
    Other morbid association(s)
    TypeGene ModificationChromosome rearrangementProtein expressionProtein Function
    tumoral     --low  
    during the development and progression of prostate cancer
    Variant & Polymorphism
    Candidate gene
    Therapy target might be a pharmacological target for drug development to modulate Glucocorticoid receptor function
    1s a potential therapeutic target for degenerative muscular diseases