basic FUNCTION
| sequestering CCNT1 into an inactive 7SK/HEXIM1/CCNT1 small nuclear ribonucleic acid particle for inhibition of transcription and, consequently, cell proliferation |
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dual roles in transcriptional regulation: inhibition of transcriptional elongation dependent on 7SK RNA and positive transcription elongation factor b and interference with the sequence-specific transcription factor GR via a direct protein-protein interaction |
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coregulator of ERalpha transcriptional activity |
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playing an inhibitory role in NF-kappa B dependent gene expression in vascular smooth muscle cells |
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possible role for HEXIM1 ubiquitination in the regulation of CCNT1 activity |
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involved in other nuclear and cytoplasmic processes besides controlling CDK9 |
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may act as a gene-selective transcriptional regulator via direct interaction with certain transcriptional regulators including GR and contribute to fine-tuning of, for example, glucocorticoid-mediated biological responses |
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inhibits phosphorylation of RNA polymerase II by interacting with the positive transcription elongation factor CCNT1, regulating the transcription elongation |
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regulates estrogen-induced VEGF transcription through inhibition of estrogen receptor-alpha recruitment to the VEGF promoter |
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having a inhibitory role during angiogenesis and a role for HEXIM1 in cancer progression |
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potential for HEXIM1 to indirectly act on multiple cell types to suppress metastatic cancer |
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crucial role for the HEXIM1/CCNT1 pathway in the regulation of satellite cell–mediated muscle regeneration |
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plays a critical role in the inhibition of the androgen receptor by anti-androgens |
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might be a novel factor involved in maintaining whole-body energy balance |
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transcription elongation regulator, acting as a melanoma tumor suppressor that responds to nucleotide stress |
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plays an important role in inhibiting cancer cell-specific gene transcription while also facilitating anti-cancer gene expression, and in coupling nucleotide metabolism with transcriptional regulation in melanoma |
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acts as a tumor suppressor and is involved in the regulation of innate immunity |
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in addition to its action on CCNT1, plays a role in a variety of different mechanisms: it controls the stability of transcription factor components and assists binding of transcription factors to their targets |