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FLASH GENE
Symbol HES6 contributors: mct - updated : 28-01-2012
HGNC name hairy and enhancer of split 6 (Drosophila)
HGNC id 18254
Location 2q37.3      Physical location : 239.146.909 - 239.148.681
Synonym name
  • likely ortholog of mouse Hes6 neuronal differentiation gene
  • transcription cofactor HES-6
  • C- HAIRY1
  • hairy and enhancer of split 6
  • Synonym symbol(s) bHLHb41, bHLHc23
    DNA
    TYPE functioning gene
    STRUCTURE 1.77 kb     4 Exon(s)
    10 Kb 5' upstream gene genomic sequence study
    regulatory sequence Promoter
    text structure activated transcription by ATOH1 through binding to three clustered E boxes of its promoter (three clustered E boxes E1, E2 and E4)
    MAPPING cloned Y linked N status provisional
    Physical map
    COPS8 2q37.3 COP9 constitutive photomorphogenic homolog subunit 8 (Arabidopsis) LOC389087 2 LOC389087 COL6A3 2q37.3 collagen, type VI, alpha 3 LOC285110 2q37.3 hypothetical LOC285110 MLPH 2q37.3 hypothetical LOC285110 PRH 2q37.3 preproprolactin-releasing peptide RAB17 2q37.3 RAB17, member RAS oncogene family LRRFIP1 2q37.3 leucine rich repeat (in FLII) interacting protein 1 FLJ40411 2q37.3 FLJ40411 protein RAMP1 2q36-q37.1 receptor (calcitonin) activity modifying protein 1 NCE2 2q37.3 NEDD8-conjugating enzyme SCLY 2q37.3 selenocysteine lyase LOC339768 2q37.3 hypothetical protein LOC339768 FLJ43374 2q37.3 FLJ43374 protein LOC389088 2 similar to hypothetical protein 4832406C22 ILKAP 2q37.3 integrin-linked kinase-associated serine/threonine phosphatase 2C LOC151174 2q37.3 hypothetical protein LOC151174 LOC391494 2 similar to TAR DNA-binding protein-43 (TDP-43) HES6 2q37.3 hairy and enhancer of split 6 (Drosophila) PER2 2q37.3 period homolog 2 (Drosophila) MIP-T3 2q37.3 microtubule-interacting protein that associates with TRAF3 ASB1 2q37 ankyrin repeat and SOCS box-containing 1 LOC339771 2q37.3 hypothetical LOC339771 HDAC4 2q37.2 histone deacetylase 4 MGC16025 2q37.3 hypothetical protein MGC16025 LOC389089 2 LOC389089
    RNA
    TRANSCRIPTS type messenger
    identificationnb exonstypebpproduct
    ProteinkDaAAspecific expressionYearPubmed
    4 - 1380 24.2 222 - 2007 17300753
    4 - 1386 - 224 - 2007 17300753
    EXPRESSION
    Type widely
       expressed in (based on citations)
    organ(s)
    SystemOrgan level 1Organ level 2Organ level 3Organ level 4LevelPubmedSpeciesStageRna symbol
    Nervousbrain     Homo sapiens
    Reproductivefemale systemovary  highly
    Skin/Tegumentskin   highly
    Visualeye   highly
    cells
    SystemCellPubmedSpeciesStageRna symbol
    Cardiovascularendothelial cell Homo sapiens
    cell lineage
    cell lines
    fluid/secretion
    at STAGE
    physiological period embryo
    Text in cochlea
    PROTEIN
    PHYSICAL PROPERTIES
    STRUCTURE
    motifs/domains
  • 1 basic helix-loop-helix (BHLH) domain
  • a orange domain
  • a WRPW motif, sufficient for acceleration of proteolysis as its fusion to two heterologous proteins, and mediating proteasomal degradation
  • HOMOLOGY
    interspecies ortholog to murine Hes6
    homolog to Xenopus Xl.209
    Homologene
    FAMILY basic helix-loop-helix family of transcription factors
    CATEGORY transcription factor
    SUBCELLULAR LOCALIZATION     intracellular
    intracellular,nucleus
    basic FUNCTION
  • suppressing HES1 from repressing transcription
  • transcriptional repressor of genes that require a BHLH protein for their transcription
  • may act as a negative regulator of myogenesis by inhibiting the functions of MYOD1 and ASH1
  • promoting, instead of inhibiting, neuronal and myogenic differentiation and probably through antagonizing the HES1 and HES5 functions
  • in the inner ear, might be involved in the differentiation of hair cells and promotes neuronal differentiation in the neural plate, the retina and in the cortex
  • basic helix-loop-helix transcription factor that functions in the differentiation of pluripotent progenitor cells and during tumorigenesis
  • estrogen-regulated gene in breast cancer cells
  • regulate proliferating cell fate in development and is known to be expressed in developing muscle
  • novel role in actin cytoskeletal dynamics in post mitotic myoblasts
  • important role for HES6 in supporting survival of glioma cells, as evidenced by reduction of cancer cell proliferation and migration after HES6 silencing
  • is important for glioma cell proliferation and migration, and may have a role in angiogenesis
  • CELLULAR PROCESS cell life, differentiation
    nucleotide, transcription, regulation
    PHYSIOLOGICAL PROCESS development , nervous system
    PATHWAY
    metabolism
    signaling
    a component
    INTERACTION
    DNA
    RNA
    small molecule
    protein
  • directly interacts with CREBBP, one of the key components of (PML-NB), via its basic domain
  • inhibitor of HES1 during neuronal development
  • direct transcriptional target of the myogenic transcription factors MYOD1 and MYF5, indicating that it is integral to the myogenic transcriptional program
  • cell & other
    REGULATION
    ASSOCIATED DISORDERS
    corresponding disease(s)
    Other morbid association(s)
    TypeGene ModificationChromosome rearrangementProtein expressionProtein Function
    tumoral     --over  
    in recurrent grade 2 astrocytomas and grade 2 or 3 oligodendrogliomas
    Susceptibility
    Variant & Polymorphism
    Candidate gene
    Marker
    Therapy target
    SystemTypeDisorderPubmed
    cancerreproductivebreast
    could be important for the development of novel anticancer drugs
    ANIMAL & CELL MODELS