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FLASH GENE
Symbol HERC5 contributors: mct - updated : 03-09-2010
HGNC name hect domain and RLD 5
HGNC id 24368
Location 4q22.1      Physical location : 89.378.267 - 89.427.305
Synonym name
  • cyclin-E-binding protein 1
  • HECT domain and RCC1-like domain-containing protein 5
  • probable E3 ubiquitin-protein ligase HERC5
  • Synonym symbol(s) CEB1, LOC51191, CCNEBP, CEBP1
    EC.number 6.3.2.-
    DNA
    TYPE functioning gene
    SPECIAL FEATURE component of a cluster
    text clustered with HERC3 and HERC6
    STRUCTURE 49.05 kb     23 Exon(s)
    MAPPING cloned Y linked N status provisional
    RNA
    TRANSCRIPTS type messenger
    identificationnb exonstypebpproduct
    ProteinkDaAAspecific expressionYearPubmed
    23 - 3525 11.67 1024 - Hochrainer (2005)
    EXPRESSION
    Type
       expressed in (based on citations)
    organ(s)
    SystemOrgan level 1Organ level 2Organ level 3Organ level 4LevelPubmedSpeciesStageRna symbol
    Cardiovascularheart    
    Endocrinethyroid    
    Lymphoid/Immunethymus    
    Nervousbrainhindbrainmedulla oblongata  
    Reproductivefemale systemovary   
     male systemtestis  highly
    cells
    SystemCellPubmedSpeciesStageRna symbol
    Skin/Tegumentkeratinocyte
    cell lineage
    cell lines
    fluid/secretion
    at STAGE
    physiological period fetal
    Text highly in fetal brain
    PROTEIN
    PHYSICAL PROPERTIES
    STRUCTURE
    motifs/domains
  • one HECT-type E3 ubiquitin-protein ligase domain
  • five RCC1 repeats, RCC1-like domains (RLD)
  • HOMOLOGY
    Homologene
    FAMILY
  • HERC family
  • CATEGORY regulatory , transport
    SUBCELLULAR LOCALIZATION     intracellular
    intracellular,cytoplasm
    intracellular,nucleus
    intracellular,nuclear envelope
    basic FUNCTION
  • directly transfering the ubiquitin to targeted substrates
  • HECT E3 ubiquitin ligase tightly regulated in LPS activated endothelial cells
  • involved in the conjugation of ISG15 to cellular proteins (Wong 2006)
  • functions as a general E3 ligase for protein ISGylation (Takeuchi 2006)
  • involved in protein modification, ubiquitin cycle
  • plays an important role in ubiquitination of NME2 (Hochrainer 2008)
  • catalyzes the conjugation of ubiquitin-like protein ISG15 onto IRF3 (Shi 2010)
  • positive regulator of innate antiviral responses that sustains IRF3 activation via a novel posttranslational modification, ISGylation (Shi 2010)
  • markedly induced by type I IFNs and functions as an ISG15 E3 ligase to promote ISGylation (Shi 2010)
  • positive regulator of antiviral innate immune responses, which maintains IRF3 stability via catalyzing ISGylation of IRF3 (Shi 2010)
  • CELLULAR PROCESS protein, degradation
    protein, ubiquitin dependent proteolysis
    PHYSIOLOGICAL PROCESS
    PATHWAY
    metabolism
    signaling
    a component
    INTERACTION
    DNA
    RNA
    small molecule
    protein
  • binds UBQLN1 and UBQLN2
  • binds to CCNA1, CCNB1, CCND1 and CCNE1
  • interaction of HERC5 with the metastasis suppressor NME2 (Hochrainer 2008)
  • specific binding protein of IRF3 (Shi 2010)
  • cell & other
    REGULATION
    activated by in endothelial cells by the pro-inflammatory cytokines tumor necrosis factor alpha and interleukin 1beta, and by lipopolysaccharide (LPS)
    ASSOCIATED DISORDERS
    ANIMAL & CELL MODELS