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FLASH GENE
Symbol HERC3 contributors: - updated : 14-03-2005
HGNC name hect domain and RLD 3
HGNC id 4876
Location 4q21      Physical location : 89.513.646 - 89.629.686
Synonym name HECT domain and RCC1-like domain protein 3
Synonym symbol(s) KIAA0032
DNA
TYPE functioning gene
SPECIAL FEATURE component of a cluster
text clustered with HERC5 and HERC6
STRUCTURE 116.00 kb     26 Exon(s)
10 Kb 5' upstream gene genomic sequence study
MAPPING cloned Y linked   status provisional
RNA
TRANSCRIPTS type messenger
EXPRESSION
Type
constitutive of
   expressed in (based on citations)
organ(s)
SystemOrgan level 1Organ level 2Organ level 3Organ level 4LevelPubmedSpeciesStageRna symbol
Cardiovascularheart   lowly
Digestiveliver    
Endocrinepancreas    
Nervousbraindiencephalonamygdala  
tissue
SystemTissueTissue level 1Tissue level 2LevelPubmedSpeciesStageRna symbol
Epithelialbarrier liningendometrium  
cell lineage
cell lines
fluid/secretion
at STAGE
physiological period fetal
Text brain
PROTEIN
PHYSICAL PROPERTIES
STRUCTURE
motifs/domains
  • at least two significant homology domains
  • a N terminus domain homolog to the regulator of chromosome condensation RCC1(-CHC)-like domain (RLD)
  • a C terminal HECT domain, characteristic of E3 ubiquitin ligases
  • seven RCC1 repeats
  • HOMOLOGY
    Homologene
    FAMILY HERC family
    CATEGORY regulatory , transport
    SUBCELLULAR LOCALIZATION     intracellular
    intracellular,cytoplasm
    intracellular,nucleus
    basic FUNCTION
  • putatively involved in protein trafficking
  • stimulating guanine nucleotide exchange
  • substrate of ubiquitination and is degraded by the proteasome
  • CELLULAR PROCESS protein, degradation
    protein, ubiquitin dependent proteolysis
    PHYSIOLOGICAL PROCESS
    PATHWAY
    metabolism
    signaling
    a component
    INTERACTION
    DNA
    RNA
    small molecule
    protein
    cell & other
    REGULATION
    ASSOCIATED DISORDERS
    ANIMAL & CELL MODELS