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FLASH GENE
Symbol HERC3 contributors: - updated : 14-03-2005
HGNC name hect domain and RLD 3
HGNC id 4876
Location 4q21      Physical location : 89.513.646 - 89.629.686
Synonym name HECT domain and RCC1-like domain protein 3
Synonym symbol(s) KIAA0032
DNA
TYPE functioning gene
SPECIAL FEATURE component of a cluster
text clustered with HERC5 and HERC6
STRUCTURE 116.00 kb     26 Exon(s)
10 Kb 5' upstream gene genomic sequence study
MAPPING cloned Y linked   status provisional
Physical map
SOAT 4q22.1 sodium-dependent organic anion transporter MGC26744 4q22.1 hypothetical protein MGC26744 LOC260422 4q21.3 actin related protein 2/3 complex subunit 1A pseudogene LOC389210 4 similar to hypothetical protein LOC391676 4 similar to Synaptic glycoprotein SC2 MLLT2 4q21 myeloid/lymphoid or mixed-lineage leukemia (trithorax homolog, Drosophila); translocated to, 2 KLHL8 4q22.1 kelch-like 8 (Drosophila) GAPDL4 4pter-p16.2 glyceraldehyde-3-phosphate dehydrogenase-like 4 SCDR9 4q22.1 short-chain dehydrogenase/reductase 9 DHRS8 4q22.1 dehydrogenase/reductase (SDR family) member 8 NUDT9 4q21.3 nudix (nucleoside diphosphate linked moiety X)-type motif 9 SPARCL1 4q27 SPARC-like 1 (mast9, hevin) DSPP 4q21.3 dentin sialophosphoprotein DMP1 4q21.2-q21.3 dentin matrix acidic phosphoprotein LOC391677 4 similar to chromosome 7 open reading frame 17 protein; 16.7kD protein IBSP 4q21-q25 integrin-binding sialoprotein (bone sialoprotein, bone sialoprotein II) MEPE 4q21.1 matrix, extracellular phosphoglycoprotein with ASARM motif (bone) HSPCP1 4q21-q25 heat shock 90kDa protein 1, beta pseudogene 1 SPP1 4q21-q25 secreted phosphoprotein 1 (osteopontin, bone sialoprotein I, early T-lymphocyte activation 1) PKD2 4q22 polycystic kidney disease 2 (autosomal dominant) ABCG2 4q22 ATP-binding cassette, sub-family G (WHITE), member 2 DKFZp761G058 4q22.1 hypothetical protein DKFZp761G058 CEB1 4q22.1-q23 hypothetical protein DKFZp761G058 MGC14156 4q22.1 hypothetical protein MGC14156 HERC3 4q21 hect domain and RLD 3 DRLM FAM13A1 4q21 family with sequence similarity 13, member A1 LOC389211 4 similar to expressed sequence AW060714 TIGD2 4q21.3 tigger transposable element derived 2 LOC285513 4q22.1 hypothetical protein LOC285513 SNCA 4q21-q22 synuclein, alpha (non A4 component of amyloid precursor) MMRN 4q22 multimerin KIAA1680 4q22 multimerin
RNA
TRANSCRIPTS type messenger
EXPRESSION
Type
constitutive of
   expressed in (based on citations)
organ(s)
SystemOrgan level 1Organ level 2Organ level 3Organ level 4LevelPubmedSpeciesStageRna symbol
Cardiovascularheart   lowly
Digestiveliver    
Endocrinepancreas    
Nervousbraindiencephalonamygdala  
tissue
SystemTissueTissue level 1Tissue level 2LevelPubmedSpeciesStageRna symbol
Epithelialbarrier liningendometrium  
cell lineage
cell lines
fluid/secretion
at STAGE
physiological period fetal
Text brain
PROTEIN
PHYSICAL PROPERTIES
STRUCTURE
motifs/domains
  • at least two significant homology domains
  • a N terminus domain homolog to the regulator of chromosome condensation RCC1(-CHC)-like domain (RLD)
  • a C terminal HECT domain, characteristic of E3 ubiquitin ligases
  • seven RCC1 repeats
  • HOMOLOGY
    Homologene
    FAMILY HERC family
    CATEGORY regulatory , transport
    SUBCELLULAR LOCALIZATION     intracellular
    intracellular,cytoplasm
    intracellular,nucleus
    basic FUNCTION
  • putatively involved in protein trafficking
  • stimulating guanine nucleotide exchange
  • substrate of ubiquitination and is degraded by the proteasome
  • CELLULAR PROCESS protein, degradation
    protein, ubiquitin dependent proteolysis
    PHYSIOLOGICAL PROCESS
    PATHWAY
    metabolism
    signaling
    a component
    INTERACTION
    DNA
    RNA
    small molecule
    protein
    cell & other
    REGULATION
    ASSOCIATED DISORDERS
    ANIMAL & CELL MODELS