| protein
| HERC2-RNF8 interaction requires ionising radiation-inducible phosphorylation of HERC2 at Thr 4827, which in turn binds to the forkhead-associated (FHA) domain of RNF8  |
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targets BARD1-uncoupled BRCA1 for degradation |
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UBE3A interaction with HERC2 is mediated by the RCC1-like domain 2 of HERC2 and a region spanning amino acid residues 150-200 of UBE3A |
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interaction between HERC2 and SLC24A4 affecting determination of blue eye colour |
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significant interactions of a redundant character between the HERC2 and OCA2 genes affecting determination of hazel eye colour |
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E3 ubiquitin ligase that targets breast cancer suppressor BRCA1 for degradation |
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in the presence of BRCA1, interacts with CLSPN, a protein essential for G(2)-M checkpoint activation and replication fork stability |
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HERC2 and the neuralized homologue NEURL4 are novel interaction partners of the centrosomal protein CCP110, and association between CCP110 and HERC2 depends on nonoverlapping regions of NEURL4 |
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both HERC2 and RNF168 were specifically modified with SUMO1 at DSB sites in a manner dependent on the SUMO E3 ligase PIAS4 |
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thought to be a key regulator of E6AP |
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is an FBXL5-associated protein |
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HERC2, a HECT domain-containing E3 ligase, as being responsible for polyubiquitination of USP33 |
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HERC2 interacts with the coiled-coil domain of USP16 through its C-terminal HECT domain |
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function of HERC2/USP20 in coordinating CHEK1 activation by modulating CLSPN stability, which ultimately promotes genome stability and suppresses tumor growth |
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USP20 is phosphorylated by ATR, resulting in disassociation of the E3 ubiquitin ligase HERC2 from USP20 and USP20 stabilization |
