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FLASH GENE
Symbol HELT contributors: mct - updated : 12-03-2007
Location 4q35.1      Physical location : 185.940.082 - 185.941.925
Genatlas name Hey-like transcriptional repressor
Synonym name
  • Megane bHLH factor
  • HES-like
  • Heslike
  • Hey-like transcription factor
  • Synonym symbol(s) Mgn, HESL, HCM1228
    DNA
    TYPE functioning gene
    STRUCTURE 1.00 kb     4 Exon(s)    1 Copie(s)
    MAPPING cloned Y linked   status provisional
    RNA
    TRANSCRIPTS type messenger
    identificationnb exonstypebpproduct
    ProteinkDaAAspecific expressionYearPubmed
    4 - 984 - 327 - Guimera (2006)
    EXPRESSION
    Type restricted
    constitutive of
       expressed in (based on citations)
    organ(s)
    SystemOrgan level 1Organ level 2Organ level 3Organ level 4LevelPubmedSpeciesStageRna symbol
    Nervousbrainmidbrain   
     brainforebrain   
    Reproductivefemale systemovary  lowly
    cell lineage
    cell lines
    fluid/secretion
    at STAGE
    physiological period embryo
    PROTEIN
    PHYSICAL PROPERTIES
    STRUCTURE
    motifs/domains
  • helix-loop-helix domain
  • orange domain
  • secondary structure bHLH-O
    mono polymer homomer , heteromer , dimer
    HOMOLOGY
    interspecies homolog to murine Helt (91,49 pc)
    Homologene
    FAMILY
  • bHLH-O family
  • CATEGORY transcription factor
    SUBCELLULAR LOCALIZATION     intracellular
    intracellular,nucleus
    basic FUNCTION
  • involved in neuronal differentiation
  • acting as a transcriptional repressor
  • CELLULAR PROCESS nucleotide, transcription, regulation
    PHYSIOLOGICAL PROCESS development , nervous system
    PATHWAY
    metabolism
    signaling
    a component
    INTERACTION
    DNA
  • binding
  • RNA
    small molecule
    protein
  • homodimerization by the bHLH and Orange domains
  • heterodimerization with Hes5 by the Orange domain
  • heterodimerization with Hey2 by the bHLH domain
  • cell & other
    REGULATION
    ASSOCIATED DISORDERS
    ANIMAL & CELL MODELS