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FLASH GENE
Symbol HECW2 contributors: SGE/npt - updated : 05-01-2010
HGNC name HECT, C2 and WW domain containing E3 ubiquitin protein ligase 2
HGNC id 29853
Location 2q32.3      Physical location : 197.063.976 - 197.457.335
Synonym name NEDD4-related E3 ubiquitin ligase NEDL2
Synonym symbol(s) KIAA1301, NEDL2, DKFZp686M17164
EC.number 6.3.2.-
DNA
TYPE functioning gene
STRUCTURE 393.36 kb     29 Exon(s)
MAPPING cloned Y linked N status provisional
RNA
TRANSCRIPTS type messenger
identificationnb exonstypebpproduct
ProteinkDaAAspecific expressionYearPubmed
29 - 6926 - 1572 - -
EXPRESSION
Type
   expressed in (based on citations)
organ(s)
SystemOrgan level 1Organ level 2Organ level 3Organ level 4LevelPubmedSpeciesStageRna symbol
Cardiovascularheart   predominantly
Digestiveliver    
Nervousbrain   predominantly
Reproductivefemale systemovary   
 male systemtestis   
Respiratorylung   predominantly
cell lineage
cell lines
fluid/secretion
at STAGE
PROTEIN
PHYSICAL PROPERTIES
STRUCTURE
motifs/domains
  • one C2 domain at its NH(2)-terminus
  • two WW domains
  • one HECT domain at its COOH-terminus
  • conjugated PhosphoP
    HOMOLOGY
    interspecies homolog to murine Hecw2 (95.2pc)
    homolog to rattus Hecw2 (94.7pc)
    Homologene
    FAMILY
    CATEGORY enzyme
    SUBCELLULAR LOCALIZATION     intracellular
    intracellular,cytoplasm
    basic FUNCTION
  • involved in protein modification, ubiquitin cycle
  • E3 ubiquitin-protein ligase that mediates ubiquitination of TP73, to stabilize TP73 and enhance activation of transcription by TP73
  • CELLULAR PROCESS protein, ubiquitin dependent proteolysis
    PHYSIOLOGICAL PROCESS
    PATHWAY
    metabolism
    signaling
    a component
    INTERACTION
    DNA
    RNA
    small molecule
    protein
  • interacting with TP73
  • cell & other
    REGULATION
    ASSOCIATED DISORDERS
    ANIMAL & CELL MODELS