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FLASH GENE
Symbol HECTD3 contributors: mct/pgu - updated : 04-06-2012
HGNC name HECT domain containing 3
HGNC id 26117
Location 1p34.1      Physical location : 45.468.220 - 45.477.027
Synonym name
  • probable E3 ubiquitin-protein ligase HECTD3
  • HECT domain-containing protein 3
  • Synonym symbol(s) FLJ21156, FLJ31983, MGC161630, RP11-69J16.1
    EC.number 6.3.2.-
    DNA
    TYPE functioning gene
    STRUCTURE 8.81 kb     21 Exon(s)
    MAPPING cloned Y linked N status provisional
    RNA
    TRANSCRIPTS type messenger
    identificationnb exonstypebpproduct
    ProteinkDaAAspecific expressionYearPubmed
    21 - 3628 97 861 - 2008 18194665
    EXPRESSION
    Type
       expressed in (based on citations)
    organ(s)
    SystemOrgan level 1Organ level 2Organ level 3Organ level 4LevelPubmedSpeciesStageRna symbol
    Endocrineadrenal gland    
     thyroid    
    Reproductivefemale systembreastmammary gland  
    Respiratoryrespiratory tracttrachea   
    tissue
    SystemTissueTissue level 1Tissue level 2LevelPubmedSpeciesStageRna symbol
    Connectivebone   
    cell lineage
    cell lines
    fluid/secretion lymph
    at STAGE
    PROTEIN
    PHYSICAL PROPERTIES
    STRUCTURE
    motifs/domains
  • an HECT domain
  • besides HECT domain, contains an anaphase-promoting complex, subunit 10 (APC10) domain
  • HOMOLOGY
    interspecies homolog to murine Hectd3 (95.8pc)
    Homologene
    FAMILY
    CATEGORY enzyme , regulatory
    SUBCELLULAR LOCALIZATION     intracellular
    intracellular,cytoplasm
    basic FUNCTION
  • may be involved int he regulation of mitotic metaphase/anaphase transition
  • can specifically ubiquitinate TRIOBP and target it for proteasomal degradation
  • may facilitate cell cycle progression via regulating ubiquitination and degradation of TRIOBP
  • CELLULAR PROCESS cell cycle, division, mitosis
    protein, ubiquitin dependent proteolysis
    PHYSIOLOGICAL PROCESS
    PATHWAY
    metabolism
    signaling
    a component
  • component of the anaphase promoting complex
  • INTERACTION
    DNA
    RNA
    small molecule
    protein
  • TRIOBP-binding protein (directly binds TRIOBP and forms a complex with TRIOBP, and HECTD3 may facilitate cell cycle progression via regulating ubiquitination and degradation of TRIOBP)
  • directly interacts with HECTD3 and the overexpression of HECTD3 promotes the ubiquitination of STX8
  • cell & other
    REGULATION
    ASSOCIATED DISORDERS
    corresponding disease(s)
    Other morbid association(s)
    TypeGene ModificationChromosome rearrangementProtein expressionProtein Function
    constitutional     --over  
    enhances the ubiquitination of Tara and decreases Tara stability
    Susceptibility
    Variant & Polymorphism
    Candidate gene
    Marker
    Therapy target
    ANIMAL & CELL MODELS