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FLASH GENE
Symbol HEBP1 contributors: - updated : 14-09-2006
HGNC name heme binding protein 1
HGNC id 17176
Location 12p13.2      Physical location : 13.127.800 - 13.153.243
Synonym symbol(s) HBP, HEBP, F2L
DNA
TYPE functioning gene
STRUCTURE 25.00 kb     4 Exon(s)
10 Kb 5' upstream gene genomic sequence study
MAPPING cloned Y linked N status provisional
Physical map
BCLG 12p13-p12 glutamate receptor, ionotropic, N-methyl D-aspartate 2B LOC387839 12 similar to prothymosin alpha LRP6 12p11.2-p13.3 low density lipoprotein receptor-related protein 6 MORF4LP4 4q1.2 mortality factor 4 like pseudogene 4 FLJ10298 12p13.2 hypothetical protein FLJ10298 LOH12CR1 12p12 loss of heterozygosity, 12, chromosomal region 1 LOC387840 12 LOC387840 DUSP16 12p13-p12 dual specificity phosphatase 16 LOC390296 12 similar to hypothetical protein CREBL2 12p13.2-p13.1 cAMP responsive element binding protein-like 2 GPR19 12p12.3 G protein-coupled receptor 19 CDKN1B 12p13.1-p12 cyclin-dependent kinase inhibitor 1B (p27, Kip1) DKFZP434F0318 12p13.2 hypothetical protein DKFZp434F0318 DDX47 12p13.2 DEAD (Asp-Glu-Ala-Asp) box polypeptide 47 LOC341465 12p13.2 similar to 40S ribosomal protein S6 (Phosphoprotein NP33) LOC387841 12 similar to ribosomal protein L13a; 60S ribosomal protein L13a; 23 kD highly basic protein RAI3 12p13-p12.3 retinoic acid induced 3 GPRC5D 12p13.3 G protein-coupled receptor, family C, group 5, member D HEBP1 12p13.2 heme binding protein 1 LOC387842 12 similar to 5-hydroxytryptamine receptor 7 isoform a; serotonin 5-HT-7 receptor KIAA1467 12p13.2 KIAA1467 protein GSG1 12p13.31 germ cell associated 1 EMP1 12p12.3 epithelial membrane protein 1 FLJ33810 12p13.2 hypothetical protein FLJ33810 GRIN2B 12p12 glutamate receptor, ionotropic, N-methyl D-aspartate 2B
RNA
TRANSCRIPTS type messenger
EXPRESSION
Type ubiquitous
constitutive of
   expressed in (based on citations)
organ(s)
SystemOrgan level 1Organ level 2Organ level 3Organ level 4LevelPubmedSpeciesStageRna symbol
Cardiovascularheart    
Endocrineneuroendocrinepituitary  highly
 parathyroid   highly
Hearing/Equilibriumear   highly
Lymphoid/Immunethymus    
Reproductivemale systemprostate   
Respiratorylung    
tissue
SystemTissueTissue level 1Tissue level 2LevelPubmedSpeciesStageRna symbol
Blood / Hematopoieticbone marrow   
Connectivebone   
Epithelialsecretoryglandularendocrine 
Epithelialsecretoryglandularexocrine 
Lymphoid    
Muscularstriatumcardiac  
Muscularstriatumskeletal  
cell lineage
cell lines
fluid/secretion
at STAGE
PROTEIN
PHYSICAL PROPERTIES globular
STRUCTURE
motifs/domains
  • natural chemoattractant peptide of 21 amino acids at the N-terminus, which is a natural ligand for formyl peptide receptor-like
  • mono polymer monomer
    HOMOLOGY
    interspecies ortholog to murine Hebp1
    homolog to chicken soul
    homolog to Rattus Rn.6886
    Homologene
    FAMILY
    CATEGORY immunity/defense
    SUBCELLULAR LOCALIZATION     intracellular
    intracellular,cytoplasm
    basic FUNCTION
  • intracellular tetrapyrrole-binding protein may be involved in heme protein biosynthesis
  • promotes calcium mobilization and chemotaxis in monocytes and dendritic cells
  • CELLULAR PROCESS
    PHYSIOLOGICAL PROCESS circadian
    PATHWAY
    metabolism porphyrin/heme
    signaling
    a component
    INTERACTION
    DNA
    RNA
    small molecule other,
    heme, free porphyrins and methylprotoporphyrin
    protein binds and activates FPRL2 in the low nanomolar range, which triggers intracellular calcium release and inhibition of cAMP accumulation
    cell & other
    REGULATION
    ASSOCIATED DISORDERS
    corresponding disease(s)
    Susceptibility
    Variant & Polymorphism
    Candidate gene
    Marker
    Therapy target
    ANIMAL & CELL MODELS
    chicken and murine models