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FLASH GENE
Symbol HDGF contributors: mct/npt/pgu - updated : 27-09-2013
HGNC name hepatoma-derived growth factor (high-mobility group protein 1-like)
HGNC id 4856
Location 1q23.1      Physical location : 156.711.899 - 156.722.240
Synonym name
  • high-mobility group protein 1-like 2
  • hepatoma-derived growth factor
  • Synonym symbol(s) HMG1L2, RP11-66D17.10, DKFZp686J1764, FLJ96580
    DNA
    TYPE functioning gene
    STRUCTURE 10.34 kb     6 Exon(s)
    Genomic sequence alignment details
    10 Kb 5' upstream gene genomic sequence study
    MAPPING cloned Y linked N status provisional
    Physical map
    LOC92312 1q22-q23.1 hypothetical protein LOC92312 LMNA 1q21.2-q21.3 lamin A/C FLJ12287 1q22 hypothetical protein FLJ12287 similar to semaphorins LOC388706 1 LOC388706 KIAA0446 1q23.1 KIAA0446 gene product PMF1 1q12-q21.1 polyamine-modulated factor 1 BGLAP 1q25-q31 bone gamma-carboxyglutamate (gla) protein (osteocalcin) PAQR6 1q23.1 progestin and adipoQ receptor family member VI EST1B 1q21.2 Est1p-like protein B MGC13102 1q23.1 hypothetical protein MGC13102 MGC31963 1q23.1 kidney predominant protein NCU-G1 LOC391104 1 similar to Von Hippel-Lindau disease tumor suppressor (pVHL) (G7 protein) CCT3 1q23 chaperonin containing TCP1, subunit 3 (gamma) SSTK-IP 1q23.1 SSTK-interacting protein RHBG 1q21.3 Rhesus blood group, B glycoprotein CROC4 1q12-q25 Rhesus blood group, B glycoprotein MEF2D 1q12-q23 MADS box transcription enhancer factor 2, polypeptide D (myocyte enhancer factor 2D) IQGAP3 1q21.3 IQ motif containing GTPase activating protein 3 LOC164118 1q23.1 similar to RIKEN cDNA A430025D11 APOA1BP 1q21.2 apolipoprotein A-I binding protein FLJ20249 1q22 hypothetical protein FLJ20249 BRAL1 1q22 hypothetical protein FLJ20249 BCAN 1q23-q31 hypothetical protein FLJ20249 NES 1q23.1 nestin CRABP2 1q21.3 cellular retinoic acid binding protein 2 FLJ12671 1q23.1 hypothetical protein FLJ12671 CGI-41 1q23.1 CGI-41 protein MRPL24 1q21-q22 mitochondrial ribosomal protein L24 HDGF Xq25 hepatoma-derived growth factor (high-mobility group protein 1-like) PRCC 1q21.2 papillary renal cell carcinoma (translocation-associated) SH2D2A 1q21 SH2 domain protein 2A INSRR 1q21-q23 insulin receptor-related receptor NTRK1 1q22 neurotrophic tyrosine kinase, receptor, type 1 FLJ00193 1q23.1 FLJ00193 protein FLJ32884 1q23.1 hypothetical protein FLJ32884 ARHGEF11 1q21-q23 Rho guanine nucleotide exchange factor (GEF) 11 LOC246784 1q21.3 homolog of C. elegans smu-1 pseudogene LOC149501 1q23.1 similar to KRT8 protein HCP2 1q22 cytochrome c, somatic pseudogene ETV3 1q21-q23 ets variant gene 3
    RNA
    TRANSCRIPTS type messenger
    identificationnb exonstypebpproduct
    ProteinkDaAAspecific expressionYearPubmed
    6 - 2397 27 240 - 2007 1797402
    6 - 2183 25.4 233 - 2007 1797402
    6 - 2208 28 256 - 2007 1797402
    EXPRESSION
    Type
       expressed in (based on citations)
    organ(s)
    SystemOrgan level 1Organ level 2Organ level 3Organ level 4LevelPubmedSpeciesStageRna symbol
    Cardiovascularheart    
    Digestiveliver    
    Nervousbrain   highly
    Reproductivemale systemtestis  predominantly
    Respiratorylung    
    Urinarykidney    
    tissue
    SystemTissueTissue level 1Tissue level 2LevelPubmedSpeciesStageRna symbol
    Muscularstriatumskeletal  
    cell lineage
    cell lines
    fluid/secretion
    at STAGE
    physiological period pregnancy
    Text placenta
    PROTEIN
    PHYSICAL PROPERTIES
    STRUCTURE
    motifs/domains
  • N-terminal PWWP domain required for the DNA binding
  • a putative nuclear localization signal (NLS)
  • a C terminal acidic region, without any apparent HGM motif
  • conjugated PhosphoP
    HOMOLOGY
    Homologene
    FAMILY
  • HDGF family
  • CATEGORY signaling growth factor
    SUBCELLULAR LOCALIZATION extracellular
        intracellular
    intracellular,cytoplasm
    intracellular,nucleus,nucleoplasm
    basic FUNCTION
  • heparin-binding protein, with mitogenic activity for fibroblasts
  • playing an important role in the development or progression of hepatocellular carcinoma
  • transcriptional repressor, exerting its transcription repressive effect through binding to a conserved DNA element in the promoter of target genes
  • involvement of HDGF during the initiation phase of the apoptotic process downstream from an initiator Caspase and a regulation of this protein by phosphorylation in the nucleus
  • may play a critical role in the pathobiology of lung cancer through its mitogenic and angiogenic activities
  • having both mitogenic and angiogenic activity and is highly expressed in the developing heart and vasculature
  • involved in cell growth, cell invasion, and apoptosis.
  • nuclear protein that is a mitogen for a wide variety of cells
  • could function as a transcriptional repressor
  • functions as a transcriptional repressor of the SMYD1 gene through interaction with the transcriptional corepressor CTBP1, CTBP2
  • secreted heparin-binding growth factor that has been implicated in cancer development and progression
  • its over-expression may exert a prognostic role for tumour metastasis and recurrence in breast cancer by modulating epithelial-mesenchymal transition
  • CELLULAR PROCESS
    PHYSIOLOGICAL PROCESS
    PATHWAY
    metabolism
    signaling
    a component
  • forms a transcriptional complex with CTBP1and CTBP2
  • INTERACTION
    DNA
    RNA
    small molecule
    protein
  • repressed SMYD1 gene transcription through interaction with a transcriptional corepressor C-terminal binding proteins CTBP1, CTBP2
  • critical target for transcriptional repression by the tumor suppressor TP53
  • interaction of HDGF and nucleolin (expression of a cytosolic variant of HDGF causes a redistribution of nucleolin into the cytoplasm)
  • cell & other
    REGULATION
    Other cell cycle regulated phosphorylation of HDGF may play an important role in vascular cell proliferation
    ASSOCIATED DISORDERS
    corresponding disease(s)
    Other morbid association(s)
    TypeGene ModificationChromosome rearrangementProtein expressionProtein Function
    tumoral     --over  
    in cancer and its expression is correlated with poor prognosis of cancer
    tumoral     --over  
    in primary gastric, breast, and lung cancer tissues harboring mutant TP53 genes
    constitutional     --over  
    in the dermis of keloid compared with normal skin tissue
    Susceptibility
    Variant & Polymorphism
    Candidate gene prognostic factor for gastrointestinal stromal tumors patients
    Marker
    Therapy target potential target for cancer therapy
    ANIMAL & CELL MODELS