basic FUNCTION
| promoting the repression mediated via transcriptional corepressor NCOR2 |
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acting as a regulator of NR4A1 and apoptosis in developing thymocytes |
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maintaining vascular integrity by repressing the expression of matrix metalloproteinase (MMP) 10 |
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being responsible for the deacetylation of lysine residues on the N-terminal part of the core histones (H2A, H2B, H3 and H4) |
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promotes PML sumoylation and is essential for PML nuclear body formation |
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having a crucial role in maintaining vascular integrity |
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key modulator of endothelial cell migration and hence angiogenesis, at least in part, by regulating PDGF-B/PDGFR-beta gene expression |
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role for HDAC7 and FOXA1 in estrogen repression of RPRM, a mechanism which could potentially be generalized to many more estrogen-repressed genes and hence be important in both normal physiology and pathological processes |
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plays a central role in restoration of cystic fibrosis mutation ÄF508 function |
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expressed in the early stages of embryonic development and may play a role in endothelial function |
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neuroprotective protein acting by a mechanism that is independent of its deacetylase activity but involving the inhibition of JUN expression |
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unexpected function for HDAC7 in osteoclasts that is distinct from the function of HDAC3 (represses osteoclast differentiation) |
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HDAC5, HDAC7, and EHMT2 are involved in the transcriptional repression activity of PARP2 |
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in B cells HDAC7 is a transcriptional repressor of undesirable genes, suggesting a role for HDAC7 in maintaining the identity of a particular cell type by silencing lineage-inappropriate genes |
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promotes Toll-like receptor 4-dependent proinflammatory gene expression in macrophages |
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suppresses proliferation and CTNNB activity in chondrocytes, and reducing HDAC7 levels in early chondrocytes may promote the expansion and regeneration of cartilage tissues |
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has a potent anti-oncogenic effect on specific B-cell malignancies, indicating that its deregulation may contribute to the pathogenesis of the disease |