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FLASH GENE
Symbol HDAC7 contributors: mct/ - updated : 13-06-2015
HGNC name histone deacetylase 7
HGNC id 14067
Location 12q13.11      Physical location : 48.176.508 - 48.213.763
Synonym name
  • histone deacetyltransferase 7
  • histone deacetylase 7A
  • Synonym symbol(s) HDAC7A, DKFZP586J0917, FLJ99588, HD7, HD7AA,
    EC.number 3.5.1.98
    DNA
    TYPE functioning gene
    STRUCTURE 37.90 kb     25 Exon(s)
    MAPPING cloned Y linked N status provisional
    RNA
    TRANSCRIPTS type messenger
    identificationnb exonstypebpproduct
    ProteinkDaAAspecific expressionYearPubmed
    25 splicing 4301 - 991 - 2008 18625722
    25 splicing 4190 - 954 - 2008 18625722
  • lacking exon 7
  • using an alternative splice site in exon 8
  • 23 exons
  • - - 2925 - 974 - -
    EXPRESSION
    Type ubiquitous
       expressed in (based on citations)
    organ(s)
    SystemOrgan level 1Organ level 2Organ level 3Organ level 4LevelPubmedSpeciesStageRna symbol
    Digestiveliver   highly
    Endocrineparathyroid   moderately
    Lymphoid/Immunelymph node   moderately
     thymus   predominantly
     tonsils   highly
    Nervousnerve   highly
    Reproductivefemale systemovary  highly
    tissue
    SystemTissueTissue level 1Tissue level 2LevelPubmedSpeciesStageRna symbol
    Connectivebone  moderately
    cells
    SystemCellPubmedSpeciesStageRna symbol
    Lymphoid/ImmuneT cell
    cell lineage
    cell lines
    fluid/secretion highly in lymph
    at STAGE
    physiological period embryo, fetal
    Text in the vascular endothelium during early embryogenesis, moderately in umbilical cord
    PROTEIN
    PHYSICAL PROPERTIES
    STRUCTURE
    motifs/domains
  • a catalytic domain having an additional class IIa HDAC-specific zinc binding motif adjacent to the active site which is likely to participate in substrate recognition and protein-protein interaction and may provide a site for modulation of activity
  • conjugated PhosphoP
    HOMOLOGY
    interspecies ortholog to rattus Hdac7a (90pc)
    ortholog to murine Hdac7a (90.3pc)
    Homologene
    FAMILY
  • histone deacetylase family
  • type 2 subfamily
  • CATEGORY enzyme , transcription factor
    SUBCELLULAR LOCALIZATION     intracellular
    intracellular,cytoplasm,organelle,mitochondria,inner
    intracellular,nucleus,nucleoplasm
    intracellular,nucleus,chromatin/chromosome
    text exported from the nucleus during T cell receptor activation
    basic FUNCTION
  • promoting the repression mediated via transcriptional corepressor NCOR2
  • acting as a regulator of NR4A1 and apoptosis in developing thymocytes
  • maintaining vascular integrity by repressing the expression of matrix metalloproteinase (MMP) 10
  • being responsible for the deacetylation of lysine residues on the N-terminal part of the core histones (H2A, H2B, H3 and H4)
  • promotes PML sumoylation and is essential for PML nuclear body formation
  • having a crucial role in maintaining vascular integrity
  • key modulator of endothelial cell migration and hence angiogenesis, at least in part, by regulating PDGF-B/PDGFR-beta gene expression
  • role for HDAC7 and FOXA1 in estrogen repression of RPRM, a mechanism which could potentially be generalized to many more estrogen-repressed genes and hence be important in both normal physiology and pathological processes
  • plays a central role in restoration of cystic fibrosis mutation ÄF508 function
  • expressed in the early stages of embryonic development and may play a role in endothelial function
  • neuroprotective protein acting by a mechanism that is independent of its deacetylase activity but involving the inhibition of JUN expression
  • unexpected function for HDAC7 in osteoclasts that is distinct from the function of HDAC3 (represses osteoclast differentiation)
  • HDAC5, HDAC7, and EHMT2 are involved in the transcriptional repression activity of PARP2
  • in B cells HDAC7 is a transcriptional repressor of undesirable genes, suggesting a role for HDAC7 in maintaining the identity of a particular cell type by silencing lineage-inappropriate genes
  • promotes Toll-like receptor 4-dependent proinflammatory gene expression in macrophages
  • suppresses proliferation and CTNNB activity in chondrocytes, and reducing HDAC7 levels in early chondrocytes may promote the expansion and regeneration of cartilage tissues
  • has a potent anti-oncogenic effect on specific B-cell malignancies, indicating that its deregulation may contribute to the pathogenesis of the disease
  • CELLULAR PROCESS cell cycle, progression
    cell life, differentiation
    nucleotide, chromatin organization, remodeling
    nucleotide, transcription, regulation
    PHYSIOLOGICAL PROCESS development , inflammation
    text
  • transcriptional corepressor
  • B cell differentiation
  • negative regulation of striated muscle development
  • nervous system development
  • regulation of progression through cell cycle
  • PATHWAY
    metabolism
    signaling
    a component
  • HDAC7 directly binds to beta-catenin and forms a complex with YWHAE, YWHAZ, and YWHAH proteins
  • INTERACTION
    DNA
    RNA
    small molecule
    protein
  • NCOR2
  • HDAC5
  • HDAC3
  • HDAC1
  • HDAC2
  • HDAC4
  • NCOR1
  • SIN3A
  • SIN3B
  • RBBP4
  • RBBP7
  • MTA1L1
  • SAP30
  • MBD3
  • 14-3-3 protein YWHAE
  • MEF2A
  • MEF2B
  • MEF2C
  • HTATIP
  • EDNRA
  • interacting with MAML1 (SUMOylation of MAML1 is a mechanism for repressing MAML1 activity by influencing its interaction with HDAC7)
  • inhibits the transcriptional activity of RUNX2 in maturing osteoblasts in a deacetylase-independent manner
  • represses MITF at least in part by deacetylation-independent mechanism
  • AKAP12 tumor/angiogenesis suppressor gene is an epigenetic target of HDAC7
  • upon TNFSF11 activation, HDAC7 suppresses NFATC1 and prevents CTNNB1 down-regulation, thereby blocking osteoclast differentiation
  • PARP2 interacts and recruits histone deacetylases HDAC5 and HDAC7, and histone methyltransferase EHMT2 to the promoters of cell cycle-related genes, generating repressive chromatin signatures
  • HLCS acts as a biotin-independent transcriptional repressor interacting with HDAC1, HDAC2 and HDAC7
  • HDAC7 suppresses RUNX2 activity and osteoblast differentiation, and suppresses proliferation and CTNNB1 activity in chondrocytes
  • TNF-mediated suppression of steroidogenesis involves HDAC7 in Leydig cells
  • cell & other
    REGULATION
    activated by VEGF (VEGF stimulates PKD1-dependent HDAC7 phosphorylation and cytoplasmic accumulation in endothelial cells modulating gene expression and angiogenesis)
    Other regulated by PPP2R4 (controlling the subcellular localization and repressive function of HDAC7, and endothelial angiogenic functions and T cell apoptosis)
    ASSOCIATED DISORDERS
    corresponding disease(s)
    Other morbid association(s)
    TypeGene ModificationChromosome rearrangementProtein expressionProtein Function
    constitutional     --low  
    silencing in endothelial cells altered their morphology, their migration, and their capacity to form capillary tube-like structures but did not affect cell adhesion, proliferation, or apoptosis
    constitutional     --low  
    decreased in age-related macular degeneration (AMD)
    Susceptibility
    Variant & Polymorphism
    Candidate gene
    Marker
    Therapy target
    SystemTypeDisorderPubmed
    cancer  
    may represent a rational target for therapeutic intervention against cancer
    respiratoryCF (mucoviscidosis) 
    reducing the activity of the lung-enriched HDAC7 can trigger altered expression of a subset of cystic fibrosis–interacting gene products and, potentially, unknown factors to generate a new cellular environment that is both protective and corrective for C
    neurologyneurodegenerative 
    increasing HDAC7 levels in the brain by pharmacologically stimulating endogenous expression, or by delivering it to vulnerable neuronal populations via viral or other delivery systems, might represent a therapeutic approach to reduce cell death in neurode
    ANIMAL & CELL MODELS
    disruption of the HDAC7 gene in mice results in embryonic lethality due to a failure in endothelial cell-cell adhesion and consequent dilatation and rupture of blood vessels