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FLASH GENE
Symbol HDAC11 contributors: mct/npt - updated : 17/10/2008
HGNC name histone deacetylase 11
HGNC id 19086
Location 3p25.1      Physical location : 13.521.714 - 13.547.923
Synonym symbol(s) FLJ22237, DRPD3, HD11
EC.number 3.5.1.98
DNA
TYPE functioning gene
STRUCTURE 25.01 kb     10 Exon(s)
10 Kb 5' upstream gene genomic sequence study
MAPPING cloned Y linked N status provisional
RNA
TRANSCRIPTS type messenger
identificationnb exonstypebpproduct
ProteinkDaAAspecific expressionYearPubmed
10 - 1755 39 347 - Voelter-Mahlknecht (2005)
EXPRESSION
Type widely
   expressed in (based on citations)
organ(s)
SystemOrgan level 1Organ level 2Organ level 3Organ level 4LevelPubmedSpeciesStageRna symbol
Cardiovascularheart    
Digestivemouth   highly
Nervousbrain   highly
 nerve   highly
Reproductivemale systemtestis   
Urinarykidney    
tissue
SystemTissueTissue level 1Tissue level 2LevelPubmedSpeciesStageRna symbol
Muscularstriatumskeletal  
cell lineage
cell lines
fluid/secretion
at STAGE
PROTEIN
PHYSICAL PROPERTIES
STRUCTURE
motifs/domains
HOMOLOGY
interspecies ortholog to murine Hdac11
Homologene
FAMILY
  • histone deacetylase/acuc/alpha family
  • HD subfamily 1
  • class IV HDACs family
  • CATEGORY enzyme
    SUBCELLULAR LOCALIZATION     intracellular
    intracellular,nucleus
    basic FUNCTION
  • involved in the deacetylation of lysine residues on the N terminal part of the core histones (H2A, H2B, H3, H4)
  • control DNA expression by modifying the core histone octamers that package DNA into dense chromatin structures and repress gene expression
  • CELLULAR PROCESS cell cycle, progression
    nucleotide, chromatin organization, remodeling
    nucleotide, transcription, regulation
    PHYSIOLOGICAL PROCESS development
    PATHWAY
    metabolism
    signaling
    a component
  • associating with HDAC6
  • INTERACTION
    DNA
    RNA
    small molecule
    protein
    cell & other
    REGULATION
    inhibited by trapoxin
    ASSOCIATED DISORDERS
    ANIMAL & CELL MODELS