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FLASH GENE
Symbol HDAC10 contributors: mct/npt - updated : 27-08-2012
HGNC name histone deacetylase 10
HGNC id 18128
Location 22q13.31      Physical location : 50.683.614 - 50.689.834
Synonym symbol(s) MGC149722, DKFZP761B039, HD10
EC.number 3.5.1.98
DNA
TYPE functioning gene
SPECIAL FEATURE head to head
STRUCTURE 6.22 kb     20 Exon(s)
10 Kb 5' upstream gene genomic sequence study
regulatory sequence Binding site
MAPPING cloned Y linked N status provisional
RNA
TRANSCRIPTS type messenger
identificationnb exonstypebpproduct
ProteinkDaAAspecific expressionYearPubmed
20 splicing 2720 - 669 - 2002 11677242
20 exons, Nterminal catalytic domain ,two putative C-terminal retinoblastoma protein binding domains and a nuclear hormone receptor binding motif
19 splicing 2660 - 649 - 2002 11677242
  • an 82bp alternate exon
  • EXPRESSION
    Type widely
       expressed in (based on citations)
    organ(s)
    SystemOrgan level 1Organ level 2Organ level 3Organ level 4LevelPubmedSpeciesStageRna symbol
    Cardiovascularheart    
    Digestiveliver    
    Lymphoid/Immunelymph node   highly
     thymus   highly
    Nervousbrain    
    Reproductivefemale systemuteruscervix highly
    Respiratorylung    
    Urinarykidney    
    tissue
    SystemTissueTissue level 1Tissue level 2LevelPubmedSpeciesStageRna symbol
    Lymphoid    
    cell lineage
    cell lines
    fluid/secretion
    at STAGE
    PROTEIN
    PHYSICAL PROPERTIES
    STRUCTURE
    motifs/domains
  • an N terminal catalytic domain, half that is highly similar to the first deacetylase domain of HDAC6, a DAC domain
  • a C terminal pseudo-repeat sharing significant homology with its catalytic domain (putative second catalytic domain), half Leu rich, and a catalytically inactive LRD in the C-terminal region
  • a unique leucine-rich domain
  • HOMOLOGY
    interspecies ortholog to murine Hdac10
    homolog to Drosophila CG13645
    intraspecies homolog to HDAC6
    Homologene
    FAMILY
  • histone deacetylase/acuc/alpha family
  • histone deacetylases class IIb
  • CATEGORY enzyme
    SUBCELLULAR LOCALIZATION     intracellular
    intracellular,cytoplasm
    intracellular,nucleus,nucleoplasm
    basic FUNCTION
  • involved in the deacetylation of lysine residues on the N terminal part of the core histones (H2A, H2B, H3, H4)
  • may be playing a role in transcription regulation
  • HDAC10 regulates melanogenesis but the transcriptional activities of PAX3 and TRIM28 are intimately linked to their acetylation status
  • function of HDAC9 and HDAC10 in the homologous recombination process
  • critical role of HDAC10 in suppression of cervical cancer metastasis
  • CELLULAR PROCESS cell cycle, progression
    nucleotide, chromatin organization, remodeling
    nucleotide, transcription, regulation
    PHYSIOLOGICAL PROCESS development
    PATHWAY
    metabolism
    signaling
    a component
    INTERACTION
    DNA
    RNA
    small molecule
    protein
  • HDAC10 physically interacted with PAX3 and KAP1 in a ternary complex and maintained PAX3 and TRIM28 in a deacetylated state
  • cell & other
    REGULATION
    ASSOCIATED DISORDERS
    corresponding disease(s)
    Susceptibility
    Variant & Polymorphism
    Candidate gene
    Marker
    Therapy target
    SystemTypeDisorderPubmed
    cancerreproductiveuterus
    importance of developing isoform-specific HDAC inhibitors for treatment of certain cancer types such as cervical squamous cell carcinoma
    ANIMAL & CELL MODELS