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FLASH GENE
Symbol HDAC10 contributors: mct/npt - updated : 27-08-2012
HGNC name histone deacetylase 10
HGNC id 18128
Location 22q13.31      Physical location : 50.683.614 - 50.689.834
Synonym symbol(s) MGC149722, DKFZP761B039, HD10
EC.number 3.5.1.98
DNA
TYPE functioning gene
SPECIAL FEATURE head to head
STRUCTURE 6.22 kb     20 Exon(s)
10 Kb 5' upstream gene genomic sequence study
regulatory sequence Binding site
MAPPING cloned Y linked N status provisional
Physical map
ALG12 22q13.3 endothelial cell growth factor 1 (platelet-derived) MGC11256 22p13 hypothetical protein MGC11256 LOC164714 22q13.33 similar to RIKEN cDNA 1700019P01 MLC1 22q13.33 megalencephalic leukoencephalopathy with subcortical cysts 1 MOV10L1 22q13.33 Mov10l1, Moloney leukemia virus 10-like 1, homolog (mouse) PANX2 22q13.33 pannexin 2 PP2447 22q13.33 hypothetical protein PP2447 SELO 22q13.33 selenoprotein O TUBGCP6 22q13.31-q13.33 tubulin, gamma complex associated protein 6 HDAC10 22q13.31 histone deacetylase 10 MAPK12 22q13.33 mitogen-activated protein kinase 12 MAPK11 22q13.33 mitogen-activated protein kinase 11 PLXNB2 22q13.31-q13.33 plexin B2 KIAA0685 22q13.3 plexin B2 SBF1 22q13.33 SET binding factor 1 FLJ21135 ALDRL6 22q13.3 aldehyde reductase (aldose reductase) like 6 BC002942 22q13.33 hypothetical protein BC002942 384D8-2 22q13.33 hypothetical protein 384D8_6 SCO2 22q13.33 SCO cytochrome oxidase deficient homolog 2 (yeast) ECGF1 22q13.3 endothelial cell growth factor 1 (platelet-derived)
RNA
TRANSCRIPTS type messenger
identificationnb exonstypebpproduct
ProteinkDaAAspecific expressionYearPubmed
20 splicing 2720 - 669 - 2002 11677242
20 exons, Nterminal catalytic domain ,two putative C-terminal retinoblastoma protein binding domains and a nuclear hormone receptor binding motif
19 splicing 2660 - 649 - 2002 11677242
  • an 82bp alternate exon
  • EXPRESSION
    Type widely
       expressed in (based on citations)
    organ(s)
    SystemOrgan level 1Organ level 2Organ level 3Organ level 4LevelPubmedSpeciesStageRna symbol
    Cardiovascularheart    
    Digestiveliver    
    Lymphoid/Immunelymph node   highly
     thymus   highly
    Nervousbrain    
    Reproductivefemale systemuteruscervix highly
    Respiratorylung    
    Urinarykidney    
    tissue
    SystemTissueTissue level 1Tissue level 2LevelPubmedSpeciesStageRna symbol
    Lymphoid    
    cell lineage
    cell lines
    fluid/secretion
    at STAGE
    PROTEIN
    PHYSICAL PROPERTIES
    STRUCTURE
    motifs/domains
  • an N terminal catalytic domain, half that is highly similar to the first deacetylase domain of HDAC6, a DAC domain
  • a C terminal pseudo-repeat sharing significant homology with its catalytic domain (putative second catalytic domain), half Leu rich, and a catalytically inactive LRD in the C-terminal region
  • a unique leucine-rich domain
  • HOMOLOGY
    interspecies ortholog to murine Hdac10
    homolog to Drosophila CG13645
    intraspecies homolog to HDAC6
    Homologene
    FAMILY
  • histone deacetylase/acuc/alpha family
  • histone deacetylases class IIb
  • CATEGORY enzyme
    SUBCELLULAR LOCALIZATION     intracellular
    intracellular,cytoplasm
    intracellular,nucleus,nucleoplasm
    basic FUNCTION
  • involved in the deacetylation of lysine residues on the N terminal part of the core histones (H2A, H2B, H3, H4)
  • may be playing a role in transcription regulation
  • HDAC10 regulates melanogenesis but the transcriptional activities of PAX3 and TRIM28 are intimately linked to their acetylation status
  • function of HDAC9 and HDAC10 in the homologous recombination process
  • critical role of HDAC10 in suppression of cervical cancer metastasis
  • CELLULAR PROCESS cell cycle, progression
    nucleotide, chromatin organization, remodeling
    nucleotide, transcription, regulation
    PHYSIOLOGICAL PROCESS development
    PATHWAY
    metabolism
    signaling
    a component
    INTERACTION
    DNA
    RNA
    small molecule
    protein
  • HDAC10 physically interacted with PAX3 and KAP1 in a ternary complex and maintained PAX3 and TRIM28 in a deacetylated state
  • cell & other
    REGULATION
    ASSOCIATED DISORDERS
    corresponding disease(s)
    Susceptibility
    Variant & Polymorphism
    Candidate gene
    Marker
    Therapy target
    SystemTypeDisorderPubmed
    cancerreproductiveuterus
    importance of developing isoform-specific HDAC inhibitors for treatment of certain cancer types such as cervical squamous cell carcinoma
    ANIMAL & CELL MODELS