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FLASH GENE

Symbol

HCN3

contributors: mct/npt - updated : 18-03-2019

HGNC name	hyperpolarization activated cyclic nucleotide-gated potassium channel 3
HGNC id	19183

FLASH GENE DNA RNA EXPRESSION PROTEIN DISORDER ANIMAL & CELL MODELS

Location	1q22      Physical location : 155.247.373 - 155.259.638
Synonym name	likely ortholog of mouse hyperpolarization-activated, cyclic nucleotide-gated K+ 3
Synonym symbol(s)	KIAA1535, MGC131493

DNA

TYPE	functioning gene
STRUCTURE	12.26 kb     8 Exon(s)

Genomic sequence alignment details
10 Kb 5' upstream gene genomic sequence study

MAPPING

cloned

Y

linked

N

status

provisional

RNA

TRANSCRIPTS	type	messenger

identification nb exons type bp product Protein kDa AA specific expression Year Pubmed NM_020897 8 - 3717 NP_065948 - 774 - Stieber (2005)

EXPRESSION

Type	restricted

expressed in	(based on citations)
organ(s)	System Organ level 1 Organ level 2 Organ level 3 Organ level 4 Level Pubmed Species Stage Rna symbol Cardiovascular heart       highly Nervous brain hindbrain cerebellum     Rattus norvegicus

cells

System Cell Pubmed Species Stage Rna symbol Nervous Purkinje cell Rattus norvegicus

cell lineage

cell lines

fluid/secretion

at STAGE

PROTEIN

PHYSICAL PROPERTIES

STRUCTURE

motifs/domains	cytoplasmic domain with a domain involved in subunit assembly
	two transmembrane domains (S1,S2)
	two transmembrane domains (S3, voltage- sensing S4)
	a transmembrane domains (S5)
	a glycosylation site
	a membrane pore forming domain H5
	a transmembrane domain S6
	a cytoplasmic domain with an cAMP binding domain and a Pro-rich domain

conjugated

GlycoP , Other

mono polymer

homomer , heteromer , tetramer

HOMOLOGY

interspecies	ortholog to murine Hcn3
	homolog to rattus Hcn3

Homologene

FAMILY	potassium channel HCN family
	superfamily of voltage-gated pore loop channels

CATEGORY

transport channel

SUBCELLULAR LOCALIZATION	plasma membrane
	intracellular
	intracellular,cytoplasm,organelle,membrane

basic FUNCTION	having a hyperpolarization-activated cation (potassium) channel activity)
	inward current activated by hyperpolarization from the resting potential and an important modulator of action potential firing frequency in many excitable cells (Momin 2008)
	plays a key role in the control of cardiac and neuronal rhythmicity ("pacemaker current"), and contributes to several other neuronal processes, including determination of resting membrane potential, dendritic integration and synaptic transmission (Wahl-Schott 2009)

CELLULAR PROCESS

cell communication

PHYSIOLOGICAL PROCESS

facilitated diffusion transport

PATHWAY

metabolism

signaling

a component

INTERACTION

DNA

RNA

small molecule	metal binding, nucleotide,
	cAMP
	potassium K+

protein

cell & other

REGULATION

activated by	hyperpolarization (voltage)
	cAMP

inhibited by

rapidly and reversibly by extracellular cesium and slowly and irreversibly by extracellular applied ZD7288 (Stieber 2005)

ASSOCIATED DISORDERS

ANIMAL & CELL MODELS