Selected-GenAtlas references SOURCE GeneCards NCBI Gene Swiss-Prot Ensembl
HGNC UniGene Nucleotide OMIM UCSC
Home Page
FLASH GENE
Symbol HCN3 contributors: mct/npt - updated : 18-03-2019
HGNC name hyperpolarization activated cyclic nucleotide-gated potassium channel 3
HGNC id 19183
Location 1q22      Physical location : 155.247.373 - 155.259.638
Synonym name
  • likely ortholog of mouse hyperpolarization-activated, cyclic nucleotide-gated K+ 3
  • Synonym symbol(s) KIAA1535, MGC131493
    DNA
    TYPE functioning gene
    STRUCTURE 12.26 kb     8 Exon(s)
    Genomic sequence alignment details
    10 Kb 5' upstream gene genomic sequence study
    MAPPING cloned Y linked N status provisional
    RNA
    TRANSCRIPTS type messenger
    identificationnb exonstypebpproduct
    ProteinkDaAAspecific expressionYearPubmed
    8 - 3717 - 774 - Stieber (2005)
    EXPRESSION
    Type restricted
       expressed in (based on citations)
    organ(s)
    SystemOrgan level 1Organ level 2Organ level 3Organ level 4LevelPubmedSpeciesStageRna symbol
    Cardiovascularheart   highly
    Nervousbrainhindbraincerebellum   Rattus norvegicus
    cells
    SystemCellPubmedSpeciesStageRna symbol
    NervousPurkinje cell Rattus norvegicus
    cell lineage
    cell lines
    fluid/secretion
    at STAGE
    PROTEIN
    PHYSICAL PROPERTIES
    STRUCTURE
    motifs/domains
  • cytoplasmic domain with a domain involved in subunit assembly
  • two transmembrane domains (S1,S2)
  • two transmembrane domains (S3, voltage- sensing S4)
  • a transmembrane domains (S5)
  • a glycosylation site
  • a membrane pore forming domain H5
  • a transmembrane domain S6
  • a cytoplasmic domain with an cAMP binding domain and a Pro-rich domain
  • conjugated GlycoP , Other
    mono polymer homomer , heteromer , tetramer
    HOMOLOGY
    interspecies ortholog to murine Hcn3
    homolog to rattus Hcn3
    Homologene
    FAMILY
  • potassium channel HCN family
  • superfamily of voltage-gated pore loop channels
  • CATEGORY transport channel
    SUBCELLULAR LOCALIZATION     plasma membrane
        intracellular
    intracellular,cytoplasm,organelle,membrane
    basic FUNCTION
  • having a hyperpolarization-activated cation (potassium) channel activity)
  • inward current activated by hyperpolarization from the resting potential and an important modulator of action potential firing frequency in many excitable cells (Momin 2008)
  • plays a key role in the control of cardiac and neuronal rhythmicity ("pacemaker current"), and contributes to several other neuronal processes, including determination of resting membrane potential, dendritic integration and synaptic transmission (Wahl-Schott 2009)
  • CELLULAR PROCESS cell communication
    PHYSIOLOGICAL PROCESS facilitated diffusion transport
    PATHWAY
    metabolism
    signaling
    a component
    INTERACTION
    DNA
    RNA
    small molecule metal binding, nucleotide,
  • cAMP
  • potassium K+
  • protein
    cell & other
    REGULATION
    activated by hyperpolarization (voltage)
    cAMP
    inhibited by rapidly and reversibly by extracellular cesium and slowly and irreversibly by extracellular applied ZD7288 (Stieber 2005)
    ASSOCIATED DISORDERS
    ANIMAL & CELL MODELS