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FLASH GENE

Symbol

HCLS1

contributors: mct - updated : 29-08-2022

HGNC name	hematopoietic cell-specific Lyn substrate 1
HGNC id	4844

FLASH GENE DNA RNA EXPRESSION PROTEIN DISORDER ANIMAL & CELL MODELS

Location	3q13.33      Physical location : 121.350.246 - 121.379.791
Synonym name	cortactin-like
Synonym symbol(s)	HS1, CTTNL, LckBP1, p75

DNA

TYPE	functioning gene
STRUCTURE	29.50 kb     14 Exon(s)

10 Kb 5' upstream gene genomic sequence study

MAPPING

cloned

Y

linked

N

status

provisional

RNA

TRANSCRIPTS	type	messenger

identification nb exons type bp product Protein kDa AA specific expression Year Pubmed NM_005335 14 - 2050 NP_005326 - 486 - 2019 30537294 NM_001292041 13 - 1881 NP_001278970 - 449 - 2019 30537294

EXPRESSION

Type	restricted

expressed in	(based on citations)
organ(s)	System Organ level 1 Organ level 2 Organ level 3 Organ level 4 Level Pubmed Species Stage Rna symbol Lymphoid/Immune lymph node       highly   spleen       highly   thymus       highly   tonsils       highly

cell lineage	hematopoietic cell lineage
cell lines
fluid/secretion	lymph

at STAGE

PROTEIN

PHYSICAL PROPERTIES		Hydrophilic
STRUCTURE

motifs/domains	at least three N terminal HS1 repeats
	a helix-turn-helix DNA binding domain
	a C terminal SH3 domain
	several potential phosphorylation sites
	two clusters of potential caspase cleavage sites
	four cortactin repeats

secondary structure

at least six N terminal alpha helices

conjugated

PhosphoP

HOMOLOGY

interspecies	homolog to murine Hcls1
	homolog to Drosophila cortactin
	homolog to C.elegans Y45F10D.13

Homologene

FAMILY

CATEGORY

regulatory , transcription factor

SUBCELLULAR LOCALIZATION	plasma membrane
	intracellular
	intracellular,cytoplasm,organelle,mitochondria
	intracellular,nucleus,chromatin/chromosome

basic FUNCTION	substrate of the antigen recepto-coupled tyrosine kinase, playing a role in antigen receptor signaling for both clonal expansion and deletion in lymphoid cells
	substrate of caspase 3 (degradation in a caspase-dependent manner during apoptosis)
	is a central regulator of cytoskeleton remodeling that controls lymphocyte trafficking and homing and significantly influences the tissue invasion and infiltration in CLL
	cytoskeletal interactor in the B-cell receptor (BCR) signaling pathway whose phosphorylation correlates with prognosis in Chronic Lymphocytic Leukemia (CLL)
	is important for the activation of GTPases and integrins, and mediates signaling downstream of many receptors including BCR, TCR, and CXCR4

CELLULAR PROCESS

nucleotide, transcription, regulation

PHYSIOLOGICAL PROCESS

PATHWAY

metabolism

signaling

signal transduction

a component

forms a multiprotein complex with ANKRD54 and LYN in erythroid cells (Samuels 2009)

INTERACTION

DNA

binding

RNA

small molecule

protein	binding to HAX1 and to the SH2 and SH3 domains of HS1BP3
	HS1BP3 regulates apoptosis via HCLS1 and stimulates JUN-mediated transcription

cell & other

REGULATION

ASSOCIATED DISORDERS

corresponding disease(s)

Other morbid association(s)

Type Gene Modification Chromosome rearrangement Protein expression Protein Function tumoral     --low   in ovarian tumor

Susceptibility

Variant & Polymorphism

Candidate gene

Marker

Therapy target

ANIMAL & CELL MODELS