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FLASH GENE
Symbol HCK contributors: mct - updated : 08-04-2011
HGNC name hemopoietic cell kinase
HGNC id 4840
Location 20q11.21      Physical location : 30.639.990 - 30.689.655
Synonym name tyrosine protein kinase HCK
Synonym symbol(s) JTK9, EVI47, p59-HCK/p60-HCK
EC.number 2.7.10.2
DNA
TYPE fragile site
STRUCTURE 49.67 kb     14 Exon(s)
10 Kb 5' upstream gene genomic sequence study
MAPPING cloned Y linked   status confirmed
RNA
TRANSCRIPTS type messenger
identificationnb exonstypebpproduct
ProteinkDaAAspecific expressionYearPubmed
13 - 2168 - 505 - 2003 14551197
also called p59HCK
10 - 2165 - 525 - 2003 14551197
also called variant 2/isoform c
13 - 2165 - 504 - 2003 14551197
also called variant 2/isoform d
14 - 2234 - 506 - 2003 14551197
also called variant 3/isoform e
14 - 2232 - 505 - 2003 14551197
also called variant 4/isoform b
13 - 2168 - 526 - 2003 14551197
also called p61HCK
EXPRESSION
Type widely
constitutive of
   expressed in (based on citations)
organ(s)
SystemOrgan level 1Organ level 2Organ level 3Organ level 4LevelPubmedSpeciesStageRna symbol
Lymphoid/Immunespleen   highly
 tonsils   highly
Reproductivefemale systemovary  highly
 male systemprostate  moderately
Respiratorylung   moderately
Urinarykidney   moderately
cells
SystemCellPubmedSpeciesStageRna symbol
Lymphoid/Immunelymphocyte
cell lineage myeloid and B lymphoid lineage, cells of myelomonocytic lineage
cell lines
fluid/secretion blood
at STAGE
physiological period embryo
Text embryonic stem cells, umbilical cord
PROTEIN
PHYSICAL PROPERTIES
STRUCTURE
motifs/domains
  • one SH3 and SH2 domains, playing important roles in substrate targeting, noncatalytic regions working together as a "conformational switch" that modulates kinase activity in a manner unique to the SH3 domain and linker topologies present in the intact HCK protein
  • a bipartite kinase domain
  • HOMOLOGY
    interspecies homolog to rattus Hck (89.89 pc)
    homolog to murine Hck (90.08 pc)
    Homologene
    FAMILY
  • protein kinase superfamily
  • Tyr protein kinase family
  • Src-family kinases
  • CATEGORY enzyme , protooncogene
    SUBCELLULAR LOCALIZATION     plasma membrane
    basic FUNCTION
  • contributing to neutrophil migration and regulating the degranulation process of neutrophils
  • EIF2AK2 and HCK were critical for DON-induced ribosomal recruitment of MAPK14, its subsequent phosphorylation, and, ultimately, MAPK14-driven proinflammatory cytokine expression
  • acts as a key regulator controlling gene expression in alternatively activated monocytes/macrophages
  • major signaling kinase in alternatively activated monocytes/macrophages by IL13, implicating a central role for SRC family kinases in atherogenesis and chronic inflammation
  • critical for regulating alternative activation of monocytes/macrophages
  • CELLULAR PROCESS
    PHYSIOLOGICAL PROCESS
    PATHWAY
    metabolism
    signaling
    a component
    INTERACTION
    DNA
    RNA
    small molecule nucleotide,
  • ATP
  • protein
  • interacting with ADAM15 (regulates leukocyte function)
  • interacting with RAPGEF1, to activate kinase-dependent and caspase-mediated apoptosis, which is independent of catalytic domain of C3G
  • recruited by integrin alpha(M)beta(2)
  • interacting with TP73 (HCK-SH3 domain-mediated interactions play an important role in the inhibition of TP73-dependent transcriptional activation of a target gene, NLRC4, as well as apoptosis)
  • interacting with CSF1R (dysregulated activation of HCK at the Golgi disturbs N-glycosylation of a cytokine receptor CSF1R)
  • PDCD6IP is a novel HCK (haemopoietic cell kinase) SH3 domain interactor
  • regulates the expression of mannose receptor, CD36, and MAOA in alternatively activated monocytes by IL13
  • cell & other
  • membrane associated
  • REGULATION
    activated by Gproteins alphaS and alphaI
    ASSOCIATED DISORDERS
    ANIMAL & CELL MODELS