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FLASH GENE

Symbol

HCK

contributors: mct - updated : 08-04-2015

HGNC name	hemopoietic cell kinase
HGNC id	4840

FLASH GENE DNA RNA EXPRESSION PROTEIN DISORDER ANIMAL & CELL MODELS

Location	20q11.21      Physical location : 30.639.990 - 30.689.655
Synonym name	tyrosine protein kinase HCK
Synonym symbol(s)	JTK9, EVI47, p59-HCK/p60-HCK
EC.number	2.7.10.2

DNA

TYPE	fragile site
STRUCTURE	49.67 kb     14 Exon(s)

10 Kb 5' upstream gene genomic sequence study

MAPPING

cloned

Y

linked

status

confirmed

RNA

TRANSCRIPTS	type	messenger

identification nb exons type bp product Protein kDa AA specific expression Year Pubmed NM_001172129 13 - 2168 NP_001165600 - 505 - 2003 14551197 also called p59HCK NM_001172130 10 - 2165 NP_001165601 - 525 - 2003 14551197 also called variant 2/isoform c NM_001172131 13 - 2165 NP_001165602 - 504 - 2003 14551197 also called variant 2/isoform d NM_001172132 14 - 2234 NP_001165603 - 506 - 2003 14551197 also called variant 3/isoform e NM_001172133 14 - 2232 NP_001165604 - 505 - 2003 14551197 also called variant 4/isoform b NM_002110 13 - 2168 NP_002101 - 526 - 2003 14551197 also called p61HCK

EXPRESSION

Type

widely

constitutive of

expressed in	(based on citations)
organ(s)	System Organ level 1 Organ level 2 Organ level 3 Organ level 4 Level Pubmed Species Stage Rna symbol Lymphoid/Immune spleen       highly   tonsils       highly Reproductive female system ovary     highly   male system prostate     moderately Respiratory lung       moderately Urinary kidney       moderately

cells

System Cell Pubmed Species Stage Rna symbol Lymphoid/Immune lymphocyte

cell lineage	myeloid and B lymphoid lineage, cells of myelomonocytic lineage
cell lines
fluid/secretion	blood

at STAGE

physiological period

embryo

Text	embryonic stem cells, umbilical cord

PROTEIN

PHYSICAL PROPERTIES

STRUCTURE

motifs/domains	one SH3 and SH2 domains, playing important roles in substrate targeting, noncatalytic regions working together as a "conformational switch" that modulates kinase activity in a manner unique to the SH3 domain and linker topologies present in the intact HCK protein
	a bipartite kinase domain

HOMOLOGY

interspecies	homolog to rattus Hck (89.89 pc)
	homolog to murine Hck (90.08 pc)

Homologene

FAMILY	protein kinase superfamily
	Tyr protein kinase family
	Src-family kinases

CATEGORY

enzyme , protooncogene

SUBCELLULAR LOCALIZATION

plasma membrane

basic FUNCTION	contributing to neutrophil migration and regulating the degranulation process of neutrophils
	EIF2AK2 and HCK were critical for DON-induced ribosomal recruitment of MAPK14, its subsequent phosphorylation, and, ultimately, MAPK14-driven proinflammatory cytokine expression
	acts as a key regulator controlling gene expression in alternatively activated monocytes/macrophages
	major signaling kinase in alternatively activated monocytes/macrophages by IL13, implicating a central role for SRC family kinases in atherogenesis and chronic inflammation
	critical for regulating alternative activation of monocytes/macrophages

CELLULAR PROCESS

PHYSIOLOGICAL PROCESS

PATHWAY

metabolism

signaling

a component

INTERACTION

DNA

RNA

small molecule	nucleotide,
	ATP

protein	interacting with ADAM15 (regulates leukocyte function)
	interacting with RAPGEF1, to activate kinase-dependent and caspase-mediated apoptosis, which is independent of catalytic domain of C3G
	recruited by integrin alpha(M)beta(2)
	interacting with TP73 (HCK-SH3 domain-mediated interactions play an important role in the inhibition of TP73-dependent transcriptional activation of a target gene, NLRC4, as well as apoptosis)
	interacting with CSF1R (dysregulated activation of HCK at the Golgi disturbs N-glycosylation of a cytokine receptor CSF1R)
	PDCD6IP is a novel HCK (haemopoietic cell kinase) SH3 domain interactor
	regulates the expression of mannose receptor, CD36, and MAOA in alternatively activated monocytes by IL13
	C-terminal 40 amino acids of HCK selectively bound to NLRP12 PYD + NBD

cell & other

membrane associated

REGULATION

activated by

Gproteins alphaS and alphaI

ASSOCIATED DISORDERS

ANIMAL & CELL MODELS