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FLASH GENE
Symbol HCK contributors: mct - updated : 08-04-2011
HGNC name hemopoietic cell kinase
HGNC id 4840
Location 20q11.21      Physical location : 30.639.990 - 30.689.655
Synonym name tyrosine protein kinase HCK
Synonym symbol(s) JTK9, EVI47, p59-HCK/p60-HCK
EC.number 2.7.10.2
DNA
TYPE fragile site
STRUCTURE 49.67 kb     14 Exon(s)
10 Kb 5' upstream gene genomic sequence study
MAPPING cloned Y linked   status confirmed
Physical map
LOC391241 20 similar to Soggy-1 protein precursor (SGY-1) LOC149935 20q11.21 similar to CDK5 regulatory subunit associated protein 3; CDK5 activator-binding protein C53; ischemic heart CDK5 activator-binding protein C53 RPL31P3 20p11-q11 ribosomal protein L31 pseudogene 3 DEFB118 20q11.1-q11.22 defensin, beta 118 DEFB119 20q11.1 defensin, beta 119 DEFB123 20q11.1 defensin, beta 123 REM 20q11.1 RAS (RAD and GEM)-like GTP-binding LOC388794 20 similar to dJ1093G12.6 (A novel protein) HM13 20q11.21 histocompatibility (minor) 13 ID1 20q11 inhibitor of DNA binding 1, dominant negative helix-loop-helix protein COX4I2 20q11.21 cytochrome c oxidase subunit IV isoform 2 BCL2L1 20q11.1 BCL2-like 1 TPX2 20q11.2 TPX2, microtubule-associated protein homolog (Xenopus laevis) MYLK2 20q13.31 myosin light chain kinase 2, skeletal muscle FKHL18 20q11.1-q11.2 forkhead-like 18 (Drosophila) DUSP15 20 dual specificity phosphatase-like 15 LOC164395 20q11.21 hypothetical protein LOC164395 C20orf126 20q11.21 chromosome 20 open reading frame 126 LOC343702 20q11.21 similar to dJ310O13.4 (novel protein similar to predicted C. elegans and C. intestinalis proteins) C20orf160 20q11.2 chromosome 20 open reading frame 160 HCK 20q11.21 hemopoietic cell kinase TM9SF4 20q11.21 transmembrane 9 superfamily protein member 4 RPL24P1 20q11 ribosomal protein L24 pseudogene 1 TSPYL3 20q11.1 TSPY-like 3 PLAGL2 20q11.1 pleiomorphic adenoma gene-like 2 POFUT1 20q11 protein O-fucosyltransferase 1 KIF3B 20p11.2-q11.21 kinesin family member 3B ASXL1 20q11 additional sex combs like 1 (Drosophila) DKFZP566G1424 20q11.1-q11.23 hypothetical protein DKFZp566G1424 C20orf112 20q11.1-q11.23 chromosome 20 open reading frame 112 LOC284804 20q11.21 hypothetical protein LOC284804 LOC149950 20q11.21 hypothetical LOC149950 FLJ33706 20q11.22 hypothetical protein FLJ33706 C20orf92 20q11.22 chromosome 20 open reading frame 92 DNMT3B 20q11.2 DNA (cytosine-5-)-methyltransferase 3 beta MAPRE1 20q11.1-q11.23 microtubule-associated protein, RP/EB family, member 1 LOC388795 20 similar to hypothetical protein FLJ33620
RNA
TRANSCRIPTS type messenger
identificationnb exonstypebpproduct
ProteinkDaAAspecific expressionYearPubmed
13 - 2168 - 505 - 2003 14551197
also called p59HCK
10 - 2165 - 525 - 2003 14551197
also called variant 2/isoform c
13 - 2165 - 504 - 2003 14551197
also called variant 2/isoform d
14 - 2234 - 506 - 2003 14551197
also called variant 3/isoform e
14 - 2232 - 505 - 2003 14551197
also called variant 4/isoform b
13 - 2168 - 526 - 2003 14551197
also called p61HCK
EXPRESSION
Type widely
constitutive of
   expressed in (based on citations)
organ(s)
SystemOrgan level 1Organ level 2Organ level 3Organ level 4LevelPubmedSpeciesStageRna symbol
Lymphoid/Immunespleen   highly
 tonsils   highly
Reproductivefemale systemovary  highly
 male systemprostate  moderately
Respiratorylung   moderately
Urinarykidney   moderately
cells
SystemCellPubmedSpeciesStageRna symbol
Lymphoid/Immunelymphocyte
cell lineage myeloid and B lymphoid lineage, cells of myelomonocytic lineage
cell lines
fluid/secretion blood
at STAGE
physiological period embryo
Text embryonic stem cells, umbilical cord
PROTEIN
PHYSICAL PROPERTIES
STRUCTURE
motifs/domains
  • one SH3 and SH2 domains, playing important roles in substrate targeting, noncatalytic regions working together as a "conformational switch" that modulates kinase activity in a manner unique to the SH3 domain and linker topologies present in the intact HCK protein
  • a bipartite kinase domain
  • HOMOLOGY
    interspecies homolog to rattus Hck (89.89 pc)
    homolog to murine Hck (90.08 pc)
    Homologene
    FAMILY
  • protein kinase superfamily
  • Tyr protein kinase family
  • Src-family kinases
  • CATEGORY enzyme , protooncogene
    SUBCELLULAR LOCALIZATION     plasma membrane
    basic FUNCTION
  • contributing to neutrophil migration and regulating the degranulation process of neutrophils
  • EIF2AK2 and HCK were critical for DON-induced ribosomal recruitment of MAPK14, its subsequent phosphorylation, and, ultimately, MAPK14-driven proinflammatory cytokine expression
  • acts as a key regulator controlling gene expression in alternatively activated monocytes/macrophages
  • major signaling kinase in alternatively activated monocytes/macrophages by IL13, implicating a central role for SRC family kinases in atherogenesis and chronic inflammation
  • critical for regulating alternative activation of monocytes/macrophages
  • CELLULAR PROCESS
    PHYSIOLOGICAL PROCESS
    PATHWAY
    metabolism
    signaling
    a component
    INTERACTION
    DNA
    RNA
    small molecule nucleotide,
  • ATP
  • protein
  • interacting with ADAM15 (regulates leukocyte function)
  • interacting with RAPGEF1, to activate kinase-dependent and caspase-mediated apoptosis, which is independent of catalytic domain of C3G
  • recruited by integrin alpha(M)beta(2)
  • interacting with TP73 (HCK-SH3 domain-mediated interactions play an important role in the inhibition of TP73-dependent transcriptional activation of a target gene, NLRC4, as well as apoptosis)
  • interacting with CSF1R (dysregulated activation of HCK at the Golgi disturbs N-glycosylation of a cytokine receptor CSF1R)
  • PDCD6IP is a novel HCK (haemopoietic cell kinase) SH3 domain interactor
  • regulates the expression of mannose receptor, CD36, and MAOA in alternatively activated monocytes by IL13
  • cell & other
  • membrane associated
  • REGULATION
    activated by Gproteins alphaS and alphaI
    ASSOCIATED DISORDERS
    ANIMAL & CELL MODELS