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FLASH GENE
Symbol HCFC1R1 contributors: npt/ - updated : 10-11-2007
HGNC name host cell factor C1 regulator 1 (XPO1 dependant)
HGNC id 21198
Location 16p13.3      Physical location : 3.072.625 - 3.074.287
Synonym name HCF-1 beta-propeller interacting protein
Synonym symbol(s) HPIP, FLJ20568, MGC70711, MGC99622
DNA
TYPE functioning gene
STRUCTURE 1.66 kb     5 Exon(s)
10 Kb 5' upstream gene genomic sequence study
MAPPING cloned Y linked N status provisional
RNA
TRANSCRIPTS type messenger
identificationnb exonstypebpproduct
ProteinkDaAAspecific expressionYearPubmed
- - 1000 15.2 138 - -
- - 943 13.1 119 - -
- - 788 15.2 138 - -
EXPRESSION
Type
   expressed in (based on citations)
organ(s)
SystemOrgan level 1Organ level 2Organ level 3Organ level 4LevelPubmedSpeciesStageRna symbol
Nervousbrain    
tissue
SystemTissueTissue level 1Tissue level 2LevelPubmedSpeciesStageRna symbol
Blood / Hematopoieticbone marrow   
Muscularstriatumskeletal  
cell lineage
cell lines
fluid/secretion
at STAGE
PROTEIN
PHYSICAL PROPERTIES
STRUCTURE
motifs/domains
  • a functional HCF-binding motif
  • a leucine-rich nuclear export sequence
  • HOMOLOGY
    Homologene
    FAMILY
    CATEGORY regulatory , transport carrier
    SUBCELLULAR LOCALIZATION
    basic FUNCTION
  • shuttling between the nucleus and cytoplasm in a CRM1-dependent manner
  • leading to accumulation of HCF-1 in the cytoplasm when overexpressed
  • regulating HCF-1 activity by modulating its subcellular localization
  • CELLULAR PROCESS
    PHYSIOLOGICAL PROCESS
    PATHWAY
    metabolism
    signaling
    a component
    INTERACTION
    DNA
    RNA
    small molecule
    protein
  • binding to HCF-1
  • cell & other
    REGULATION
    ASSOCIATED DISORDERS
    ANIMAL & CELL MODELS