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FLASH GENE
Symbol HCFC1R1 contributors: npt/ - updated : 10-11-2007
HGNC name host cell factor C1 regulator 1 (XPO1 dependant)
HGNC id 21198
Location 16p13.3      Physical location : 3.072.625 - 3.074.287
Synonym name HCF-1 beta-propeller interacting protein
Synonym symbol(s) HPIP, FLJ20568, MGC70711, MGC99622
DNA
TYPE functioning gene
STRUCTURE 1.66 kb     5 Exon(s)
10 Kb 5' upstream gene genomic sequence study
MAPPING cloned Y linked N status provisional
Physical map
KCTD5 16p13.3 potassium channel tetramerisation domain containing 5 MPN 16p13.3 pancreasin SRRM2 16p13.3 serine/arginine repetitive matrix 2 TCEB2 13q12.1 transcription elongation factor B (SIII), polypeptide 2 (18kDa, elongin B) LOC246718 16p12.3 ranscription elongation factor B (SIII), polypeptide 2 (18kD, elongin B) pseudogene EOS 16p13.3 serine protease EOS TESSP1  testis serine protease 1 PRSS21 16p13.3 protease, serine, 21 (testisin) LOC124220 16p13.3 similar to common salivary protein 1 MGC52282 16p13.3 hypothetical protein MGC52282 PRSS22 16p13.3 protease, serine, 22 LOC114984 16p13.3 hypothetical protein BC014089 DKFZp761A132 16p13.3 hypothetical protein DKFZp761A132 FLJ30002 16p13.3 hypothetical protein FLJ30002 KREMEN2 16p13.3 kringle containing transmembrane protein 2 PKMYT1 16p13.3 kringle containing transmembrane protein 2 LOC388205 16 similar to RIKEN cDNA 1520401A03 gene LOC388206 16 LOC388206 CLDN9 16p13.3 claudin 9 CLDN6 16p13.3 claudin 6 TNFRSF12A 16p13.3 tumor necrosis factor receptor superfamily, member 12A HCFC1R1 16p13.3 host cell factor C1 regulator 1 (XPO1 dependant) MGC2655 16p13.3 hypothetical protein MGC2655 LOC146439 16p13.3 similar to CDNA sequence BC038613 MMP25 16p13.3 matrix metalloproteinase 25 MMPL1 16p13.3 matrix metalloproteinase-like 1 NK4 16p13.3 matrix metalloproteinase-like 1 ZNF206 16p13.3 zinc finger protein 206 MGC3771 16p13.3 hypothetical protein MGC3771 ZNF205 16p13.3 zinc finger protein 205 ZNF213 16p13.3 zinc finger protein 213 LOC197350 16p13.3 hypothetical protein LOC197350 OR1F1 16p13.3 olfactory receptor, family 1, subfamily F, member 1 OR1F2 16p13.3 olfactory receptor, family 1, subfamily F, member 2 ZNF200 16p13.3 zinc finger protein 200 MEFV 16p13.3 Mediterranean fever
RNA
TRANSCRIPTS type messenger
identificationnb exonstypebpproduct
ProteinkDaAAspecific expressionYearPubmed
- - 1000 15.2 138 - -
- - 943 13.1 119 - -
- - 788 15.2 138 - -
EXPRESSION
Type
   expressed in (based on citations)
organ(s)
SystemOrgan level 1Organ level 2Organ level 3Organ level 4LevelPubmedSpeciesStageRna symbol
Nervousbrain    
tissue
SystemTissueTissue level 1Tissue level 2LevelPubmedSpeciesStageRna symbol
Blood / Hematopoieticbone marrow   
Muscularstriatumskeletal  
cell lineage
cell lines
fluid/secretion
at STAGE
PROTEIN
PHYSICAL PROPERTIES
STRUCTURE
motifs/domains
  • a functional HCF-binding motif
  • a leucine-rich nuclear export sequence
  • HOMOLOGY
    Homologene
    FAMILY
    CATEGORY regulatory , transport carrier
    SUBCELLULAR LOCALIZATION
    basic FUNCTION
  • shuttling between the nucleus and cytoplasm in a CRM1-dependent manner
  • leading to accumulation of HCF-1 in the cytoplasm when overexpressed
  • regulating HCF-1 activity by modulating its subcellular localization
  • CELLULAR PROCESS
    PHYSIOLOGICAL PROCESS
    PATHWAY
    metabolism
    signaling
    a component
    INTERACTION
    DNA
    RNA
    small molecule
    protein
  • binding to HCF-1
  • cell & other
    REGULATION
    ASSOCIATED DISORDERS
    ANIMAL & CELL MODELS