basic FUNCTION
| role in the induction of allergies and autoimmune diseases by regulating macrophage activation and/or functions |
|
negatively regulates IFN-gamma secretion and influences the ability to induce T cell tolerance |
|
is strikingly up-regulated in peripheral blood of pregnant women, most by monocytes but not by T or B cells |
|
is a negative regulator of human T cells and regulates Th1 and Th17 cytokine secretion |
|
has a role as a regulator of pro- and anti-inflammatory innate immune responses |
|
marks human natural killer cell maturation and suppresses cell-mediated cytotoxicity |
|
transmembrane protein that is involved in the regulation of T-helper 1 cell-mediated immunity |
|
is a novel target for ADAM-mediated ectodomain shedding and suggest a role of HAVCR2 shedding in TLR-mediated immune responses of CD14(+) monocytes |
|
can stimulate T cells under conditions involving acute stimulation, suggesting that the role of HAVCR2 may vary depending on context |
|
negative regulatory molecule that plays a critical role in controlling inflammation |
|
activation-induced inhibitory molecule involved in tolerance and shown to induce T-cell exhaustion in chronic viral infection and cancers |
|
plays critical roles in both the adaptive and the innate immune system |
|
modulates microglia activity and regulates the interaction of microglia-neural cells |
|
important regulatory factor in both adaptive and innate immunity |
|
schistosome-induced expression of HAVCR2 on critical immune cell populations, which may be involved in the Th2-biased immune response and alternative activation of macrophages during infection |
|
important roles of HAVCR2 and PDCD1 pathways in regulating decidual CD8+ T-cell function and maintaining normal pregnancy |