Selected-GenAtlas references SOURCE GeneCards NCBI Gene Swiss-Prot Ensembl
HGNC UniGene Nucleotide OMIM UCSC
Home Page
FLASH GENE
Symbol HAVCR1 contributors: mct/npt/pgu - updated : 11-04-1201
HGNC name hepatitis A virus cellular receptor 1
HGNC id 17866
Location 5q33.2      Physical location : 156.456.530 - 156.485.970
Synonym name
  • T cell immunoglobin domain and mucin domain protein 1
  • kidney injury molecule 1
  • Synonym symbol(s) KIM1, TIM1, HAVCR, TIM-1, TIMD1
    DNA
    TYPE functioning gene
    SPECIAL FEATURE head to head
    STRUCTURE 29.00 kb     9 Exon(s)
    10 Kb 5' upstream gene genomic sequence study
    MAPPING cloned Y linked N status provisional
    Physical map
    FLJ11526 5q33.2 hypothetical protein FLJ11526 HAND1 5q32 heart and neural crest derivatives expressed 1 LOC389339 5 LOC389339 LARP 5q33.2 likely ortholog of mouse la related protein C5orf4 5q31-q32 chromosome 5 open reading frame 4 CNOT8 5q31-q33 CCR4-NOT transcription complex, subunit 8 GEMIN5 5q33.3 gem (nuclear organelle) associated protein 5 MRPL22 5q33.1-q33.3 mitochondrial ribosomal protein L22 LOC285643 5q33.2 similar to Chromosome-associated kinesin KIF4A (Chromokinesin) LOC391842 5 similar to 60S ribosomal protein L6 (TAX-responsive enhancer element binding protein 107) (TAXREB107) (Neoplasm-related protein C140) LOC389340 5 LOC389340 SGCD 5q33 sarcoglycan, delta (35kDa dystrophin-associated glycoprotein) LOC153743 5q33.3 similar to protein phosphatase 1, regulatory (inhibitor) subunit 2 LOC91937 5q33.3 hypothetical protein BC008988 HAVCR1 5q33.2 hepatitis A virus cellular receptor 1 HAVCR2 5q34 hepatitis A virus cellular receptor 2 CRSP9 5q33.2 cofactor required for Sp1 transcriptional activation, subunit 9, 33kDa MGC26988 5q33.3 hypothetical protein MGC26988 ITK 5q33.1 IL2-inducible T-cell kinase CYFIP2 5q34 cytoplasmic FMR1 interacting protein 2 LOC348938 5q33.3 hypothetical protein LOC348938 ADAM19 5q32-q33 a disintegrin and metalloproteinase domain 19 (meltrin beta) SOX30 5q33 a disintegrin and metalloproteinase domain 19 (meltrin beta) LOC389341 5 similar to RIKEN cDNA 4921536K21 FLJ20546 5q33.3 hypothetical protein FLJ20546 LSM11 5q33.3 U7 snRNA-associated Sm-like protein ENTH 5q23.1-q33.3 U7 snRNA-associated Sm-like protein LOC391843 5 similar to 60S acidic ribosomal protein P2 LOC345471 5q33.3 similar to Hsp90 co-chaperone Cdc37 (Hsp90 chaperone protein kinase-targeting subunit) (p50Cdc37) LOC285721 5q33.3 hypothetical LOC285721 EBF 5q34 early B-cell factor FLJ31951 5q33.3 hypothetical protein FLJ31951 MGC10067 5q33.3 hypothetical protein MGC10067 IL12B 5q31.1-q33.1 interleukin 12B (natural killer cell stimulatory factor 2, cytotoxic lymphocyte maturation factor 2, p40)
    RNA
    TRANSCRIPTS type messenger
    identificationnb exonstypebpproduct
    ProteinkDaAAspecific expressionYearPubmed
    8 - 1841 - 364 - 2007 17371991
    9 - 1493 - 364 - 2007 17371991
    EXPRESSION
    Type restricted
    constitutive of
       expressed in (based on citations)
    organ(s)
    SystemOrgan level 1Organ level 2Organ level 3Organ level 4LevelPubmedSpeciesStageRna symbol
    Digestiveintestine    
    Urinarykidneytubuleconvoluted tubuleproximal tubule 
    Visualeye    
    tissue
    SystemTissueTissue level 1Tissue level 2LevelPubmedSpeciesStageRna symbol
    Epithelialbarrier/lininguroepithelium  
    Epithelialbarrier/liningretinal pigment epithelium (RPE)  
    Epithelialsensoryvisual  
    cell lineage
    cell lines
    fluid/secretion
    at STAGE
    PROTEIN
    PHYSICAL PROPERTIES
    STRUCTURE
    motifs/domains
  • extracellular domain
  • an immunoglobulin-like domain topping a long mucin-like domain, a structure that points to a possible role in cell adhesion by homology to several known adhesion proteins
  • a signal sequence
  • a 109-amino acid cys-rich N-terminal region
  • one conserved N-glycosylation site
  • a 163-amino acid TSP-rich region with 3 N-glycosylation sites
  • conjugated HemoP
    HOMOLOGY
    interspecies ortholog to murine Havcr1
    Homologene
    FAMILY
  • immunoglobulin superfamily
  • TIM family
  • CATEGORY receptor
    SUBCELLULAR LOCALIZATION     plasma membrane
    text type 1 transmembrane protein
    basic FUNCTION
  • having a possible role in cell adhesion
  • putative adhesion protein involved in renal regeneration
  • playing a role in T helper cell development and the regulation of asthma and allergic diseases
  • phosphatidylserine receptors for the engulfment of apoptotic cells, and may also be involved in intercellular signaling in which exosomes are involved
  • endogenous ciliary receptor which interacts with PKD2
  • recruited to the TCR-signaling complex via association with CD3
  • critical component of the human T cell response
  • HAVCR1-signaling in B cells augments antibody production by enhancing B cell proliferation and differentiation
  • may be involved in the differentiation of B cells to plasma cells
  • a mucin domain-dependent protective effect of epithelial HAVCR1 expression that involves downregulation of innate immunity
  • HAVCR1-mediated epithelial cell phagocytosis of apoptotic cells protects the kidney after acute injury by downregulating innate immunity and inflammation
  • CELLULAR PROCESS
    PHYSIOLOGICAL PROCESS
    PATHWAY
    metabolism
    signaling
    a component
    INTERACTION
    DNA
    RNA
    small molecule
    protein
  • interaction with PKD2 requires the ciliary sorting motif in the N-terminus of PKD2, and the presence of a highly conserved tyrosine in the intracellular tail of HAVCR1, which has previously been shown to play a role in ciliary flow sensing
  • cell & other
    REGULATION
    ASSOCIATED DISORDERS
    corresponding disease(s)
    Other morbid association(s)
    TypeGene ModificationChromosome rearrangementProtein expressionProtein Function
    constitutional     --over  
    in urine of patients with renal acute tubular necrosis or proximal tubule injury
    tumoral     --over  
    in clear cell renal cell carcinoma
    constitutional     --over  
    in tubular epithelial cells after ischemia and exposure to nephrotoxins
    constitutional     --over  
    in the epithelia lining the cysts of polycystic kidneys
    Susceptibility
  • to atopic dermatitis susceptibility
  • to autoimmune diseases
  • Variant & Polymorphism other
  • 5383_5397del variation site of exon 4 might be associated with atopic dermatitis susceptibility
  • haplotypes associated with mRNA expression levels and susceptibility to autoimmune diseases
  • Candidate gene
    Marker
    Therapy target
    ANIMAL & CELL MODELS