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FLASH GENE
Symbol HAUS6 contributors: mct/npt/pgu - updated : 24-03-2010
HGNC name HAUS augmin-like complex, subunit 6
HGNC id 25948
Location 9p22.1      Physical location : 19.053.141 - 19.102.902
Synonym name
  • protein FAM29A
  • family with sequence similarity 29, member A
  • dim gamma-tubulin homolog
  • Synonym symbol(s) FLJ20060, KIAA1574, MGC102696, MGC138798, MGC138799, RP11-296P7.3, FAM29A, dgt6
    DNA
    TYPE functioning gene
    STRUCTURE 49.76 kb     17 Exon(s)
    MAPPING cloned Y linked N status provisional
    RNA
    TRANSCRIPTS type messenger
    identificationnb exonstypebpproduct
    ProteinkDaAAspecific expressionYearPubmed
    17 - 6334 - 955 - 2009 19427217
    EXPRESSION
    Type
       expressed in (based on citations)
    organ(s)
    SystemOrgan level 1Organ level 2Organ level 3Organ level 4LevelPubmedSpeciesStageRna symbol
    Lymphoid/Immunelymph node    
    Reproductivefemale systembreastmammary gland  
     male systemtestis  highly
    tissue
    SystemTissueTissue level 1Tissue level 2LevelPubmedSpeciesStageRna symbol
    Muscular    
    cell lineage
    cell lines Ewing's sarcoma
    fluid/secretion
    at STAGE
    physiological period embryo
    Text stem cells
    PROTEIN
    PHYSICAL PROPERTIES
    STRUCTURE
    motifs/domains
    HOMOLOGY
    interspecies homolog to rattus LOC366403
    Homologene
    FAMILY
  • HAUS6 family
  • CATEGORY unknown/unspecified
    SUBCELLULAR LOCALIZATION     intracellular
    intracellular,cytoplasm,cytoskeleton,microtubule,mitotic spindle
    basic FUNCTION
  • spindle-associated protein that promotes microtubule-dependent microtubule amplification and is required for efficient chromosome congression and segregation in mammalian cells
  • promotes microtubule-dependent microtubule amplification through its interaction with and recruitment of NEDD1, the targeting subunit of the gamma-tubulin ring complex
  • target of PLK1 regulation, controls the partitioning of NEDD1 between the mitotic spindle and the centrosomes, and controls the relative contributions of these two pathways to microtubule polymerization during mitosis
  • associates with spindle microtubules and directly interacts with and recruits NEDD1, the targeting subunit of gamma-tubulin ring complex
  • CELLULAR PROCESS
    PHYSIOLOGICAL PROCESS
    PATHWAY
    metabolism
    signaling
    a component
    INTERACTION
    DNA
    RNA
    small molecule
    protein
  • interacts with the NEDD1-gamma-tubulin complex and recruits this complex to the spindle, which, in turn, promotes microtubule polymerization
  • cell & other
    REGULATION
    Other regulated by PLK1, a kinase essential for spindle assembly and its bipolarity
    ASSOCIATED DISORDERS
    ANIMAL & CELL MODELS