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FLASH GENE
Symbol HAUS1 contributors: mct/npt - updated : 23-04-2020
HGNC name HAUS augmin-like complex, subunit 1
HGNC id 25174
Location 18q21.1      Physical location : 43.684.297 - 43.708.298
Synonym name
  • coiled-coil domain containing 5 (spindle associated)
  • enhancer of invasion-cluster
    • Synonym symbol(s) HEI-C, HsT1461, CCDC5, FLJ40084, FLJ21094
    DNA
    TYPE functioning gene
    STRUCTURE 23.97 kb     9 Exon(s)
    MAPPING cloned Y linked N status provisional
    RNA
    TRANSCRIPTS type messenger
    identificationnb exonstypebpproduct
    ProteinkDaAAspecific expressionYearPubmed
    9 - 1145 - 278 - 2009 19427217
    EXPRESSION
    Type
       expressed in (based on citations)
    organ(s)
    SystemOrgan level 1Organ level 2Organ level 3Organ level 4LevelPubmedSpeciesStageRna symbol
    Reproductivefemale systemovary   
     female systemplacenta   
    cell lineage
    cell lines retinoblastoma
    fluid/secretion
    at STAGE
    physiological period pregnancy
    Text placenta
    PROTEIN
    PHYSICAL PROPERTIES
    STRUCTURE
    motifs/domains
    HOMOLOGY
    Homologene
    FAMILY
  • HAUS1 family
    • CATEGORY DNA associated
    SUBCELLULAR LOCALIZATION     intracellular
    intracellular,cytoplasm,cytosolic
    intracellular,cytoplasm,cytoskeleton,microtubule,centrosome
    intracellular,cytoplasm,cytoskeleton,microtubule,mitotic spindle
    basic FUNCTION
  • regulator of spindle function and integrity during the metaphase-anaphase transition
  • part of conserved multisubunit protein complex that regulates centrosome and spindle integrity (Lawo 2009)
    • CELLULAR PROCESS cell cycle, division, mitosis
    PHYSIOLOGICAL PROCESS
    PATHWAY
    metabolism
    signaling
    a component
  • holo-complex HAUS4 and HAUS1 are likely to be directly connected and together interact with HAUS8/HAUS6 (433–955) independent of other subunits
    • INTERACTION
    DNA
    RNA
    small molecule
    protein
    cell & other
    REGULATION
    ASSOCIATED DISORDERS
    corresponding disease(s)
    Other morbid association(s)
    TypeGene ModificationChromosome rearrangementProtein expressionProtein Function
    tumoral fusion      
    NPM1-HAUS1 in in acute myeloid leukemia
    Susceptibility
    Variant & Polymorphism
    Candidate gene
    Marker
    Therapy target
    ANIMAL & CELL MODELS