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FLASH GENE
Symbol HAT1 contributors: npt - updated : 11-02-2002
HGNC name histone acetyltransferase 1
HGNC id 4821
Location 2q31.2-q33.1      Physical location : 172.778.934 - 172.848.599
Synonym name
  • histone acetyltransferase type B catalytic subunit
  • weakly similar to M03C11.4 [C.elegans]
  • Synonym symbol(s) KAT1
    EC.number 2.3.1.48
    DNA
    TYPE functioning gene
    STRUCTURE 69.64 kb     11 Exon(s)
    10 Kb 5' upstream gene genomic sequence study
    MAPPING cloned Y linked N status provisional
    Physical map
    PPIG 2q31.1 peptidyl-prolyl isomerase G (cyclophilin G) LOC129881 2q31.1 hypothetical LOC129881 MGC22679 2q31.1 hypothetical protein MGC22679 LOC389057 2 similar to hypothetical protein MGC22679 AF357534 2q31.1 thioredoxin 1 pseudogene 7 LOC391459 2 LOC391459 SSB 2q31.1 Sjogren syndrome antigen B (autoantigen LA) HSPC133 2q31.1 HSPC133 protein LOC344287 2q31.1 similar to hypothetical protein A130030D10 KIAA2024 2q31.1 similar to F10G7.10.p MYO3B 2q31.1-q31.2 myosin IIIB LOC389058 2 similar to zinc finger protein Sp5 LOC285140 2q31.1 eukaryotic translation initiation factor 2 beta-like pseudogene LOC389059 2 LOC389059 LOC285141 2q31.1 similar to CG14853-PB GAD1 2q31 glutamate decarboxylase 1 (brain, 67kDa) GORASP2 2p24.3-q21.3 golgi reassembly stacking protein 2, 55kDa TLK1 8p22-p12 tousled-like kinase 1 FLJ13984 2q31.1 hypothetical protein FLJ13984 FLJ13096 2q31.1 hypothetical protein FLJ13096 MRPS29P2 2q31.2 mitochondrial ribosomal protein S29 pseudogene 2 LOC389060 2 similar to ribosomal protein S15 CYBRD1 2q31 cytochrome b reductase 1 LOC391460 2 similar to 60S ribosomal protein L21 DNCI2 2q24-q31 dynein, cytoplasmic, intermediate polypeptide 2 SLC25A12 2q24-q31 solute carrier family 25 (mitochondrial carrier, Aralar), member 12 HAT1 2q31.2-q33.1 histone acetyltransferase 1 MAP1D 2q31.1 methionine aminopeptidase 1D DLX1 2q32 distal-less homeo box 1 DLX2 2q32 distal-less homeo box 2 ITGA6 2q22-q31 integrin, alpha 6 PDK1 2q31.1 pyruvate dehydrogenase kinase, isoenzyme 1 CGEF2 2q31 pyruvate dehydrogenase kinase, isoenzyme 1 ZAK 2q24.2 pyruvate dehydrogenase kinase, isoenzyme 1 LOC391461 2 similar to ribosomal protein S2; 40S ribosomal protein S2 CDCA7 2q31 cell division cycle associated 7 LOC344178 2q31.1 similar to peptidylprolyl isomerase A (cyclophilin A) LOC344181 2q31.1 similar to ribosomal protein L5; 60S ribosomal protein L5 SP3 2q31 Sp3 transcription factor LOC389061 2 LOC389061 LOC389062 2 LOC389062 LOC391462 2 similar to protein 40kD PTD004 2q31.1 hypothetical protein PTD004
    RNA
    TRANSCRIPTS type messenger
    identificationnb exonstypebpproduct
    ProteinkDaAAspecific expressionYearPubmed
    - - 1672 - 334 - -
    - - 1596 49.51 419 - -
    EXPRESSION
    Type ubiquitous
       expressed in (based on citations)
    organ(s)
    SystemOrgan level 1Organ level 2Organ level 3Organ level 4LevelPubmedSpeciesStageRna symbol
    blood / hematopoieticspleen   highly
    Digestiveliver   highly
    tissue
    SystemTissueTissue level 1Tissue level 2LevelPubmedSpeciesStageRna symbol
    Lymphoid    
    cell lineage
    cell lines
    fluid/secretion
    at STAGE
    cell cycle     cell cycle, S
    PROTEIN
    PHYSICAL PROPERTIES
    STRUCTURE
    motifs/domains
  • bipartite nuclear localization signal (NLS)
  • secondary structure HAT1 and P46/HAT2 subunits
    HOMOLOGY
    interspecies homolog to Drosophila CG2051
    Homologene
    FAMILY
  • HAT1 family
  • CATEGORY enzyme , DNA associated
    SUBCELLULAR LOCALIZATION     intracellular
    intracellular,cytoplasm
    intracellular,nucleus
    basic FUNCTION
  • histone actyltransferase 1, catalytic subunit, acetylating soluble (not nucleosomal) newly synthesized histone H4 at Lys5 and Lys12,and H2A at Lys5
  • likely involved in generating modified H4 required for replication-dependent chromatin remodelingand required for DNA repair
  • CELLULAR PROCESS
    PHYSIOLOGICAL PROCESS
    PATHWAY
    metabolism
    signaling
    a component
    INTERACTION
    DNA
    RNA
    small molecule
    protein
    cell & other
    REGULATION
    ASSOCIATED DISORDERS
    ANIMAL & CELL MODELS