| basic FUNCTION
| playing a role in hyaluronan, hyaluronic acid synthesis and in hyaluronic acidic transport |
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vital because of its involvement in epithelial-mesenchymal transition during embryonic cardiac cushion morphogenesis |
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HAS1, HAS2, HAS3 act on the inner face of plasma membrane and simultaneously translocate the growing polysaccharide through plasma membrane into extracellular space |
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may mediate cellular invasion via changes in MMP7 expression  |
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playing an an intrinsic role in embryonic stem cells differentiation process |
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Hyaluronan production by HAS2 is essential for normal vertebral and intervertebral disc development within the spine |
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central role of HAS2 in the regulation of proliferation in fibroblasts |
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HAS2 and its natural antisense RNA (RNA HAS2-AS1)exhibit coordinated expression in the renal proximal tubular epithelial cell |
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critical role of HAS2 in the development of a prometastatic microenvironment, suggesting that HAS2 inhibitors can act as antimetastatic agents that disrupt a paracrine growth factor loop within this microenvironment |
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main synthase in aortic smooth muscle cells, that can be O-GlcNAcylated on serine 221, which strongly increased its activity and its stability |
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HAS1 is unable to secrete hyaluronan or form a hyaluronan coat, in contrast to HAS2 and HAS3 |
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key enzyme for the synthesis of hyaluronan (HA), as a direct target of GLI transcriptional regulation during development |
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novel downstream target of SHH signaling required for joint patterning and chondrogenesis |
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protects skin fibroblasts against apoptosis induced by environmental stress |
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general tendency of HAS1, HAS2, HAS3 to form both homomeric and heteromeric complexes with potentially important functional consequences on hyaluronan synthesis |
