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FLASH GENE
Symbol HARS2 contributors: mct - updated : 09-11-2011
HGNC name histidyl-tRNA synthetase 2, mitochondrial (putative)
HGNC id 4817
Corresponding disease
GDXD2 gonadal dysgenesis, XX type with deafness 2
Location 5q31.3      Physical location : 140.071.017 - 140.078.889
Synonym name
  • histidine translase
  • histidine-tRNA ligase homolog
  • histidyl-tRNA synthetase-like
  • histidyl-tRNA synthetase related
  • Synonym symbol(s) HO3, HARSR, SYHH, HARSL, hisRS, bA555E18.1, C20orf88
    EC.number 6.1.1.21
    DNA
    TYPE functioning gene
    SPECIAL FEATURE opposite orientation
    text head to head with HARS
    STRUCTURE 7.87 kb     13 Exon(s)
    10 Kb 5' upstream gene genomic sequence study
    MAPPING cloned Y linked N status provisional
    regionally located oriented head to head with HARS
    RNA
    TRANSCRIPTS type messenger
    identificationnb exonstypebpproduct
    ProteinkDaAAspecific expressionYearPubmed
    13 - 2508 - 506 - 2002 12056811
    EXPRESSION
    Type
       expressed in (based on citations)
    organ(s)
    SystemOrgan level 1Organ level 2Organ level 3Organ level 4LevelPubmedSpeciesStageRna symbol
    Cardiovascularheart    
    Digestiveliver    
    Nervousbrain    
    Reproductivefemale systemuterus   
    Respiratorylung    
    Urinarykidney    
    tissue
    SystemTissueTissue level 1Tissue level 2LevelPubmedSpeciesStageRna symbol
    Epithelial    
    Epithelialsensoryolfactory  
    Muscularstriatumskeletal  
    cell lineage
    cell lines
    fluid/secretion
    at STAGE
    PROTEIN
    PHYSICAL PROPERTIES
    STRUCTURE
    motifs/domains
    mono polymer homomer , dimer
    HOMOLOGY
    interspecies homolog to murine Harsl
    intraspecies homolog to histidyl-tRNA synthetase
    Homologene
    FAMILY
  • class-2 aminoacyl tRNAsynthetase family
  • CATEGORY enzyme
    SUBCELLULAR LOCALIZATION     intracellular
    intracellular,cytoplasm,organelle,mitochondria,matrix
    basic FUNCTION
  • may be playing an accessory role in the regulation of protein biosynthesis
  • play essential and nonredundant roles in cytoplasmic and mitochondrial protein translation
  • functioning as a homodimer
  • CELLULAR PROCESS
    PHYSIOLOGICAL PROCESS
    PATHWAY
    metabolism
    signaling
    a component
    INTERACTION
    DNA
    RNA
    small molecule
    protein
    cell & other
    REGULATION
    ASSOCIATED DISORDERS
    corresponding disease(s) GDXD2
    Susceptibility
    Variant & Polymorphism
    Candidate gene
    Marker
    Therapy target
    ANIMAL & CELL MODELS