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FLASH GENE
Symbol HAO2 contributors: npt/ - updated : 04-05-2004
HGNC name hydroxyacid oxidase 2 (long chain)
HGNC id 4810
Location 1p13.3-p13.2      Physical location : 119.911.401 - 119.936.751
Synonym name
  • (S)-2-hydroxy-acid oxidase
  • glycolate oxidase
  • long-chain L-2-hydroxy acid oxidase
  • growth-inhibiting protein 16
  • Synonym symbol(s) HAOX2, GIG16
    EC.number 1.1.3.15
    DNA
    TYPE functioning gene
    STRUCTURE 25.35 kb     9 Exon(s)
    Genomic sequence alignment details
    10 Kb 5' upstream gene genomic sequence study
    MAPPING cloned Y linked N status provisional
    Physical map
    LOC391072 1 similar to protease (prosome, macropain) 26S subunit, ATPase 1 LOC343492 1p12 similar to Vigilin (High density lipoprotein-binding protein) (HDL-binding protein) TBX15 1p13 T-box 15 WARS2 1p13.3-p13.1 tryptophanyl tRNA synthetase 2 (mitochondrial) LOC343495 1p11.2 similar to 60S ribosomal protein L6 (TAX-responsive enhancer element binding protein 107) (TAXREB107) (Neoplasm-related protein C140) HAO2 1p13.3-p13.2 hydroxyacid oxidase 2 (long chain) HSD3B2 1p13.1 hydroxy-delta-5-steroid dehydrogenase, 3 beta- and steroid delta-isomerase 2 LOC391073 1 similar to Glyceraldehyde 3-phosphate dehydrogenase, liver (GAPDH) LOC391074 1 similar to 3 BETA-HYDROXYSTEROID DEHYDROGENASE/DELTA 5-->4-ISOMERASE (3BETA-HSD) LOC391075 1 similar to Glyceraldehyde 3-phosphate dehydrogenase, liver (GAPDH) LOC391076 1 similar to 3 BETA-HYDROXYSTEROID DEHYDROGENASE/DELTA 5-->4-ISOMERASE (3BETA-HSD) LOC391077 1 similar to Glyceraldehyde 3-phosphate dehydrogenase, liver (GAPDH) HSD3B1 1p13.1 hydroxy-delta-5-steroid dehydrogenase, 3 beta- and steroid delta-isomerase 1 LOC391078 1 similar to Glyceraldehyde 3-phosphate dehydrogenase, liver (GAPDH) LOC391079 1 similar to 3 BETA-HYDROXYSTEROID DEHYDROGENASE/DELTA 5-->4-ISOMERASE (3BETA-HSD) LOC128102 1p11.2 3-beta-hydroxysteroid dehydrogenase, tissue-type heart LOC391080 1 similar to glyceraldehyde 3-phosphate dehydrogenase LOC391081 1 similar to 3 BETA-HYDROXYSTEROID DEHYDROGENASE/DELTA 5-->4-ISOMERASE (3BETA-HSD) MGC45731 1p11.2 hypothetical protein MGC45731 PHGDH 1p12 phosphoglycerate dehydrogenase HMGCS2 1p12 3-hydroxy-3-methylglutaryl-Coenzyme A synthase 2 (mitochondrial) REG4 1q12-q21 regenerating islet-derived family, member 4 LOC343505 1p11.2 similar to dJ1182A14.5.1 (novel gene (isoform 1)) LOC391082 1 similar to Profilin I ADAM30 1p12-p11 a disintegrin and metalloproteinase domain 30 NOTCH2 1p12-p11 Notch homolog 2 (Drosophila)
    RNA
    TRANSCRIPTS type messenger
    text variants 1 and 2 encode the same protein
    identificationnb exonstypebpproduct
    ProteinkDaAAspecific expressionYearPubmed
    - - 1476 39 351 - -
    - - 1696 39 351 - -
    EXPRESSION
    Type restricted
       expressed in (based on citations)
    organ(s)
    SystemOrgan level 1Organ level 2Organ level 3Organ level 4LevelPubmedSpeciesStageRna symbol
    blood / hematopoieticthymus    
    Digestiveliver    
    Urinarykidney    
    tissue
    SystemTissueTissue level 1Tissue level 2LevelPubmedSpeciesStageRna symbol
    Lymphoid    
    cell lineage
    cell lines
    fluid/secretion
    at STAGE
    PROTEIN
    PHYSICAL PROPERTIES
    STRUCTURE
    motifs/domains
  • a C terminal consensus type 1 peroxisomal targeting signal (PTS1) serine-arginine leucine
  • HOMOLOGY
    Homologene
    FAMILY
  • FMN-dependent alpha-hydroxy acid dehydrogenase family
  • CATEGORY enzyme
    SUBCELLULAR LOCALIZATION     intracellular
    intracellular,cytoplasm,organelle,peroxisome
    basic FUNCTION
  • 2-hydroxyacid oxidase activity
  • CELLULAR PROCESS
    PHYSIOLOGICAL PROCESS
    PATHWAY
    metabolism lipid/lipoprotein
    signaling
    highest activity toward 2 hydroxy-palmitate
    a component
    INTERACTION
    DNA
    RNA
    small molecule cofactor,
  • FMN
  • protein
    cell & other
    REGULATION
    ASSOCIATED DISORDERS
    ANIMAL & CELL MODELS