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FLASH GENE
Symbol HAO1 contributors: npt/ - updated : 01-03-2007
HGNC name hydroxyacid oxidase (glycolate oxidase) 1
HGNC id 4809
Location 20p12.3      Physical location : 7.863.630 - 7.921.093
Synonym name
  • (S)-2-hydroxy-acid oxidase
  • glycolate oxidase
    • Synonym symbol(s) GOX1, HAOX1, GOX, MGC142225, MGC142227
    EC.number 1.1.3.15
    DNA
    TYPE functioning gene
    STRUCTURE 57.00 kb     8 Exon(s)
    10 Kb 5' upstream gene genomic sequence study
    MAPPING cloned N linked   status provisional
    Map pter - D20S192 - D20S115 - HAO1 - D20S177 - cen
    Authors Gene Map (98)
    RNA
    TRANSCRIPTS type messenger
    identificationnb exonstypebpproduct
    ProteinkDaAAspecific expressionYearPubmed
    8 - 1746 40.8 370 - -
    EXPRESSION
    Type restricted
       expressed in (based on citations)
    organ(s)
    SystemOrgan level 1Organ level 2Organ level 3Organ level 4LevelPubmedSpeciesStageRna symbol
    Digestiveliver   highly
    Endocrinepancreas    
    tissue
    SystemTissueTissue level 1Tissue level 2LevelPubmedSpeciesStageRna symbol
    Epithelialsecretoryglandularendocrine 
    Epithelialsecretoryglandularexocrine 
    cell lineage
    cell lines
    fluid/secretion
    at STAGE
    PROTEIN
    PHYSICAL PROPERTIES
    STRUCTURE
    motifs/domains
  • an iron-responsive element-like sequence at the C terminus
  • type 1 peroxisomal targeting signal
  • FMN dependent dehydrogenase domain
    • HOMOLOGY
    Homologene
    FAMILY
  • FMN-dependent alpha-hydroxy acid dehydrogenase family
    • CATEGORY enzyme
    SUBCELLULAR LOCALIZATION     intracellular
    intracellular,cytoplasm,organelle,peroxisome
    basic FUNCTION
  • hydroxyacid oxidase 1, glycolate oxidase
    • CELLULAR PROCESS
    PHYSIOLOGICAL PROCESS
    PATHWAY
    metabolism organic acid
    signaling
    second reaction of the glycolate pathway
    a component
    INTERACTION
    DNA
    RNA
    small molecule cofactor,
  • FMN
    • protein
    cell & other
    REGULATION
    ASSOCIATED DISORDERS
    ANIMAL & CELL MODELS