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FLASH GENE
Symbol HAGHL contributors: KTN/npt - updated : 05/11/2008
HGNC name hydroxyacylglutathione hydrolase-like
HGNC id 14177
Location 16p13.3      Physical location : 776.957 - 779.715
Synonym name GLO2-like/ RJD12
Synonym symbol(s) MGC2605
EC.number 3.1.2.6
DNA
TYPE functioning gene
STRUCTURE 2.76 kb     11 Exon(s)
MAPPING cloned Y linked N status confirmed
RNA
TRANSCRIPTS type messenger
identificationnb exonstypebpproduct
ProteinkDaAAspecific expressionYearPubmed
7 splicing 1728 31.4 290 - -
8 splicing 1379 31.1 282 - -
EXPRESSION
Type
   expressed in (based on citations)
organ(s)
SystemOrgan level 1Organ level 2Organ level 3Organ level 4LevelPubmedSpeciesStageRna symbol
Endocrineparathyroid   moderately
Lymphoid/Immunethymus   moderately
Reproductivefemale systemuteruscervix highly
cell lineage
cell lines
fluid/secretion predominantly in lymph
at STAGE
PROTEIN
PHYSICAL PROPERTIES
STRUCTURE
motifs/domains
HOMOLOGY
interspecies homolog to dog HAGHL (88.8 pc)
homolog to chimpanzee HAGHL (83.4 pc)
homolog to murine Haghl (82.7 pc)
homolog to chicken HAGHL (67.3 pc)
Homologene
FAMILY
  • metallo-beta-lactamase superfamily
  • glyoxalase II family
  • CATEGORY enzyme
    SUBCELLULAR LOCALIZATION
    basic FUNCTION
  • being an hydrolase acting on ester bonds
  • CELLULAR PROCESS
    PHYSIOLOGICAL PROCESS
    PATHWAY
    metabolism
    signaling
    a component
    INTERACTION
    DNA
    RNA
    small molecule metal binding, cofactor,
  • Zn2+ (binding 2 ions per subunit)
  • protein
    cell & other
    REGULATION
    ASSOCIATED DISORDERS
    ANIMAL & CELL MODELS