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FLASH GENE
Symbol HAGH contributors: - updated : 03-03-2006
HGNC name hydroxyacyl glutathione hydrolase
HGNC id 4805
Location 16p13.3      Physical location : 1.859.105 - 1.877.195
Synonym name glyoxalase 2
Synonym symbol(s) GLO2, GLXII, HAGH1
EC.number 3.1.2.6
DNA
TYPE functioning gene
STRUCTURE 18.00 kb     8 Exon(s)
10 Kb 5' upstream gene genomic sequence study
MAPPING cloned   linked   status confirmed
Physical map
LOC283951 16p13.3 hypothetical protein LOC283951 LOC388201 16 LOC388201 LOC388202 16 similar to KIAA0445 protein CLCN7 16p13.3 chloride channel 7 LOC390666 16 similar to ribosomal protein S3a; 40S ribosomal protein S3a; v-fos transformation effector protein 1 LOC390667 16 similar to Neuronal pentraxin II precursor (NP-II) (NP2) KIAA0683 16p13.3 similar to Neuronal pentraxin II precursor (NP-II) (NP2) KIAA0590 16p13.3 similar to Neuronal pentraxin II precursor (NP-II) (NP2) FLJ20898 16p13.3 hypothetical protein FLJ20898 CRAMP1L 16p13.3 Crm, cramped-like (Drosophila) C16orf34 16p13.3 chromosome 16 open reading frame 34 MAPK8IP3 16p13.3 mitogen-activated protein kinase 8 interacting protein 3 NME3 16q13 non-metastatic cells 3, protein expressed in MRPS34 16p13.3 mitochondrial ribosomal protein S34 LOC390668 16 similar to hypothetical protein 6820428D13 SSB3 16p13.3 SPRY domain-containing SOCS box protein SSB-3 NUBP2 16p13.3 nucleotide binding protein 2 (MinD homolog, E. coli) IGFALS 16p13.3 insulin-like growth factor binding protein, acid labile subunit HAGH 16p13.3 hydroxyacyl glutathione hydrolase DKFZP566J2046 16p13.3 hypothetical protein DKFZp566J2046 MGC35212 16p13.3 hypothetical protein MGC35212 LOC342460 16p13.3 similar to c439A6.1 (novel protein similar to heparan sulfate (glucosamine) 3-O-sulfotransferases) SEPX1 16p13.3 selenoprotein X, 1 RPL3L 16p13.3 ribosomal protein L3-like NDUFB10 16p13.3 NADH dehydrogenase (ubiquinone) 1 beta subcomplex, 10, 22kDa RPS2 16p13.3 ribosomal protein S2 RNF151 16p13.3 ring finger protein 151 TBL3 16p13.3 transducin (beta)-like 3 NOXO1 16p13.3 NADPH oxidase organizer 1 GFER 16p13.3-p13.12 growth factor, augmenter of liver regeneration (ERV1 homolog, S. cerevisiae) SYNGR3 16p13 synaptogyrin 3 LOC90850 16p13.3 hypothetical protein LOC90850
RNA
TRANSCRIPTS type messenger
identificationnb exonstypebpproduct
ProteinkDaAAspecific expressionYearPubmed
- - 1519 28.8 260 - Cordell
  • mitochondrial, 9 exons
  • an additional 500-bp exon at the start of the sequence (termed exon A)
  • - - 1011 - - cytosolic Cordell
    8 exons
    EXPRESSION
    Type ubiquitous
    constitutive of
       expressed in (based on citations)
    organ(s)
    SystemOrgan level 1Organ level 2Organ level 3Organ level 4LevelPubmedSpeciesStageRna symbol
    Reproductivemale systemprostate  highly
    Respiratorylung   highly
    Urinarykidney   highly
    cell lineage
    cell lines
    fluid/secretion
    at STAGE
    PROTEIN
    PHYSICAL PROPERTIES
    STRUCTURE
    motifs/domains
    mono polymer monomer
    HOMOLOGY
    Homologene
    FAMILY metallo-beta-lactamase superfamily
    CATEGORY enzyme
    SUBCELLULAR LOCALIZATION     intracellular
    intracellular,cytoplasm,organelle,mitochondria
    intracellular,cytoplasm,cytosolic
    basic FUNCTION
  • catalyzing the hydrolysis of S-D- lactoyl-glutathione to form glutathione and D-lactic acid
  • CELLULAR PROCESS
    PHYSIOLOGICAL PROCESS
    PATHWAY
    metabolism
    signaling
    glyoxal pathway
    a component
    INTERACTION
    DNA
    RNA
    small molecule metal binding,
    binding two Zn2+ per subunit
    protein
    cell & other
    REGULATION
    ASSOCIATED DISORDERS
    corresponding disease(s)
    Other morbid association(s)
    TypeGene ModificationChromosome rearrangementProtein expressionProtein Function
    tumoral       gain of function
    in superficial or invasive bladder cancer
    Susceptibility
    Variant & Polymorphism
    Candidate gene
    Marker
    Therapy target
    ANIMAL & CELL MODELS