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FLASH GENE
Symbol HAGH contributors: - updated : 03-03-2006
HGNC name hydroxyacyl glutathione hydrolase
HGNC id 4805
Location 16p13.3      Physical location : 1.859.105 - 1.877.195
Synonym name glyoxalase 2
Synonym symbol(s) GLO2, GLXII, HAGH1
EC.number 3.1.2.6
DNA
TYPE functioning gene
STRUCTURE 18.00 kb     8 Exon(s)
10 Kb 5' upstream gene genomic sequence study
MAPPING cloned   linked   status confirmed
RNA
TRANSCRIPTS type messenger
identificationnb exonstypebpproduct
ProteinkDaAAspecific expressionYearPubmed
- - 1519 28.8 260 - Cordell
  • mitochondrial, 9 exons
  • an additional 500-bp exon at the start of the sequence (termed exon A)
    • - - 1011 - - cytosolic Cordell
    8 exons
    EXPRESSION
    Type ubiquitous
    constitutive of
       expressed in (based on citations)
    organ(s)
    SystemOrgan level 1Organ level 2Organ level 3Organ level 4LevelPubmedSpeciesStageRna symbol
    Reproductivemale systemprostate  highly
    Respiratorylung   highly
    Urinarykidney   highly
    cell lineage
    cell lines
    fluid/secretion
    at STAGE
    PROTEIN
    PHYSICAL PROPERTIES
    STRUCTURE
    motifs/domains
    mono polymer monomer
    HOMOLOGY
    Homologene
    FAMILY metallo-beta-lactamase superfamily
    CATEGORY enzyme
    SUBCELLULAR LOCALIZATION     intracellular
    intracellular,cytoplasm,organelle,mitochondria
    intracellular,cytoplasm,cytosolic
    basic FUNCTION
  • catalyzing the hydrolysis of S-D- lactoyl-glutathione to form glutathione and D-lactic acid
    • CELLULAR PROCESS
    PHYSIOLOGICAL PROCESS
    PATHWAY
    metabolism
    signaling
    glyoxal pathway
    a component
    INTERACTION
    DNA
    RNA
    small molecule metal binding,
    binding two Zn2+ per subunit
    protein
    cell & other
    REGULATION
    ASSOCIATED DISORDERS
    corresponding disease(s)
    Other morbid association(s)
    TypeGene ModificationChromosome rearrangementProtein expressionProtein Function
    tumoral       gain of function
    in superficial or invasive bladder cancer
    Susceptibility
    Variant & Polymorphism
    Candidate gene
    Marker
    Therapy target
    ANIMAL & CELL MODELS