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FLASH GENE
Symbol HACD3 contributors: mct - updated : 03-02-2020
HGNC name 3-hydroxyacyl-CoA dehydratase 3
HGNC id 24175
Location 15q22.31      Physical location : -
Synonym name
  • butyrate-induced transcript 1
  • protein tyrosine phosphatase-like A domain containing 1
  • very-long-chain (3R)-3-hydroxyacyl-CoA dehydratase 3
  • Synonym symbol(s) B-IND1, HSPC121, FLJ90376, PTPLAD1, BIND1
    EC.number 4.2.1.134
    DNA
    TYPE functioning gene
    STRUCTURE 47.89 kb     11 Exon(s)
    regulatory sequence Promoter
    cytosine-phosphate-guanine/HTF
    text structure promoter regulated by histone deacetylase inhibitors
    MAPPING cloned Y linked N status provisional
    RNA
    TRANSCRIPTS type messenger
    identificationnb exonstypebpproduct
    ProteinkDaAAspecific expressionYearPubmed
    11 - 3228 - 362 - 2018 30300385
    EXPRESSION
    Type
       expressed in (based on citations)
    organ(s)
    SystemOrgan level 1Organ level 2Organ level 3Organ level 4LevelPubmedSpeciesStageRna symbol
    Cardiovascularheart    
    Digestiveesophagus    
     intestinesmall intestine   
    Endocrineadrenal gland    
     neuroendocrinepituitary   
     pancreas    
    Nervousbrain    
    Reproductivemale systemtestis   
     male systemprostate   
    Respiratorylung    
    cell lineage
    cell lines
    fluid/secretion
    at STAGE
    PROTEIN
    PHYSICAL PROPERTIES
    STRUCTURE
    HOMOLOGY
    interspecies homolog to murine Ptplad1 (90.3pc)
    Homologene
    FAMILY
    CATEGORY signaling
    SUBCELLULAR LOCALIZATION     plasma membrane
        intracellular
    intracellular,cytoplasm,organelle,membrane
    intracellular,cytoplasm,organelle,endoplasmic reticulum
    intracellular,nuclear envelope
    basic FUNCTION
  • potentiating different effects of the small GTPase RAC1, such as c-Jun N-terminal kinase activation
  • transcriptional activity of nuclear factor kappaB (NF-kappaB
  • overexpressed HACD3 exhibited weak activity in saturated and monounsaturated fatty acids (FAs) elongation pathways
  • CELLULAR PROCESS
    PHYSIOLOGICAL PROCESS
    PATHWAY
    metabolism
    signaling
    a component
  • complexing with RAC1 (component of RAC1-signaling pathways leading to the modulation of gene expression)
  • INTERACTION
    DNA
    RNA
    small molecule
    protein
  • HSP90AA1-dependent chaperone pathway incorporating HACD3 is involved in protein folding in the membranous web for the circumvention of the UPR and that it facilitates HCV replication
  • ATIC, which is a rate-limiting enzyme in the de novo purine biosynthesis pathway, and PTPLAD1 are associated with insulin receptor (INSR) internalization
  • cell & other
    REGULATION
    ASSOCIATED DISORDERS
    ANIMAL & CELL MODELS