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FLASH GENE
Symbol HACD2 contributors: mct - updated : 04-02-2020
HGNC name 3-hydroxyacyl-CoA dehydratase 2
HGNC id 9640
Location 3q21.1      Physical location : -
Synonym name
  • protein tyrosine phosphatase-like (proline instead of catalytic arginine), member b
  • Synonym symbol(s) PTPLB
    EC.number 4.2.1.134
    DNA
    TYPE functioning gene
    STRUCTURE 93.55 kb     6 Exon(s)
    MAPPING cloned Y linked N status provisional
    RNA
    TRANSCRIPTS type messenger
    identificationnb exonstypebpproduct
    ProteinkDaAAspecific expressionYearPubmed
    6 - 4106 - 143 - 2017 28784662
    7 - 4125 - 254 - 2017 28784662
    9 - 4262 - 161 - 2017 28784662
    8 - 4194 - 277 - 2017 28784662
    7 - 4166 - 143 - 2017 28784662
    EXPRESSION
    Type widely
       expressed in (based on citations)
    organ(s)
    SystemOrgan level 1Organ level 2Organ level 3Organ level 4LevelPubmedSpeciesStageRna symbol
    Cardiovascularheart   highly
    Digestiveintestinelarge intestinecolon highly
     intestinesmall intestine  moderately
     liver   moderately
    Endocrinepancreas   moderately
    Lymphoid/Immunespleen   highly
     thymus   moderately
    Nervousbrain   lowly
    Reproductivefemale systemplacenta  lowly
     female systemovary  moderately
     male systemprostate  highly
     male systemtestis  highly
    Respiratorylung   lowly
    Urinarykidney   lowly
    tissue
    SystemTissueTissue level 1Tissue level 2LevelPubmedSpeciesStageRna symbol
    Muscularstriatumskeletal  
    cells
    SystemCellPubmedSpeciesStageRna symbol
    Blood/Hematopoieticleukocyte
    cell lineage
    cell lines
    fluid/secretion
    at STAGE
    physiological period pregnancy
    Text placenta
    PROTEIN
    PHYSICAL PROPERTIES
    STRUCTURE
    motifs/domains
  • four mebrane-spanning alpha helices
  • a sequence highly similar to PTP catalytic domain, except for the change of a conserved arginine to a proline, rendering the phosphatase inactive
  • a KKXX endoplasmic reticulum retention signal
  • HOMOLOGY
    interspecies homolog to murine Ptplb
    homolog to rattus LOC288058
    Homologene
    FAMILY protein tyrosine phosphatase-like B family
    CATEGORY unknown/unspecified
    SUBCELLULAR LOCALIZATION     intracellular
    intracellular,cytoplasm,organelle,membrane
    intracellular,cytoplasm,organelle,endoplasmic reticulum
    basic FUNCTION
  • HACD1 and HACD2 exhibit redundant activities in a wide range of fatty acids (FAs) elongation pathways, including those for saturated to polyunsaturated FAs, with HACD2 being the major 3-hydroxyacyl-CoA dehydratase
  • CELLULAR PROCESS
    PHYSIOLOGICAL PROCESS
    PATHWAY
    metabolism
    signaling
    a component
    INTERACTION
    DNA
    RNA
    small molecule
    protein
  • interacting with BAP31
  • cell & other
    REGULATION
    Other rapid turnover under the control of BAP31
    ASSOCIATED DISORDERS
    ANIMAL & CELL MODELS